INT174246

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Context Info
Confidence 0.68
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.58
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Cyp2b1)
Anatomy Link Frequency
CPA 1
Cyp2b1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 4 73.92 Quite High
Inflammation 13 67.36 Quite High
cytokine 42 16.00 Low Low
imagery 27 5.00 Very Low Very Low Very Low
Central nervous system 21 5.00 Very Low Very Low Very Low
Pain 16 5.00 Very Low Very Low Very Low
positron emission tomography 12 5.00 Very Low Very Low Very Low
Nerve growth factor 10 5.00 Very Low Very Low Very Low
Peripheral nervous system 8 5.00 Very Low Very Low Very Low
Multiple sclerosis 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 261 100.00 Very High Very High Very High
Glioma 29 100.00 Very High Very High Very High
Pancreatic Cancer 2 100.00 Very High Very High Very High
Cold Sores 403 97.56 Very High Very High Very High
Apoptosis 35 94.36 High High
Hypoxia 3 91.20 High High
INFLAMMATION 16 67.36 Quite High
Severe Combined Immunodeficiency 3 66.72 Quite High
Colon Cancer 19 58.96 Quite High
Toxicity 16 52.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, a new oncolytic HSV-1, MGH-2, was constructed, deleted for UL39 and ICP34.5 genes and with an insertion of the two prodrug activating genes, CYP2B1 and secreted human intestinal carboxylesterase [189, 190].
Localization (secreted) of CYP2B1 associated with cold sores
1) Confidence 0.68 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 0.48 Pain Relevance 0
CYP2B1-transduced human embryonic epithelial cells implanted in mice bearing human PaCa-44 pancreatic tumor xenografts sensitized these to IP IFO, resulting in partial or even complete tumor ablation [93]. 9L glioma cells transduced with CYP2B6 and NADPH P450 reductase were sensitized to both CPA and the bioreductive drug tirapazamine (TPZ) to the same extent under
Localization (sensitized) of CYP2B1 in CPA associated with cancer, pancreatic cancer and glioma
2) Confidence 0.20 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179761 Disease Relevance 1.10 Pain Relevance 0.17

General Comments

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