INT17425

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Context Info
Confidence 0.45
First Reported 1986
Last Reported 2010
Negated 3
Speculated 5
Reported most in Body
Documents 23
Total Number 28
Disease Relevance 18.99
Pain Relevance 5.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins1) extracellular region (Ins1) carbohydrate metabolic process (Ins1)
cytoplasm (Ins1)
Anatomy Link Frequency
plasma 7
blood 3
visceral 2
hepatocytes 2
hypothalamus 2
Ins1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 30 100.00 Very High Very High Very High
Enkephalin 19 100.00 Very High Very High Very High
Nicotine 8 100.00 Very High Very High Very High
withdrawal 6 100.00 Very High Very High Very High
Opioid 4 100.00 Very High Very High Very High
fluoxetine 12 99.68 Very High Very High Very High
narcan 5 98.52 Very High Very High Very High
imagery 15 95.40 Very High Very High Very High
tolerance 26 95.24 Very High Very High Very High
Central nervous system 20 93.64 High High
Disease Link Frequency Relevance Heat
Appetite Loss 393 100.00 Very High Very High Very High
Insulin Resistance 46 100.00 Very High Very High Very High
Hypertension 29 100.00 Very High Very High Very High
Neuropathy 14 100.00 Very High Very High Very High
Hypoglycemia 42 99.88 Very High Very High Very High
Diabetes Mellitus 420 99.84 Very High Very High Very High
Ketoacidosis 121 99.84 Very High Very High Very High
Cognitive Disorder 82 99.80 Very High Very High Very High
Disease 77 99.62 Very High Very High Very High
Ketosis 5 99.62 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Does fluoxetine administration influence insulin resistance in 90% pancreatectomized rats?
Regulation (influence) of Gene_expression (resistance) of insulin associated with insulin resistance and fluoxetine
1) Confidence 0.45 Published 2002 Journal Metab. Clin. Exp. Section Title Doc Link 11782870 Disease Relevance 0.34 Pain Relevance 0.64
Effects of age and anesthetic on plasma glucose and insulin levels and insulin sensitivity in spontaneously hypertensive and Wistar rats.
Regulation (Effects) of Gene_expression (sensitivity) of insulin in plasma associated with hypertension
2) Confidence 0.45 Published 2002 Journal Can. J. Physiol. Pharmacol. Section Title Doc Link 12450062 Disease Relevance 1.15 Pain Relevance 0.39
Effects of age and anesthetic on plasma glucose and insulin levels and insulin sensitivity in spontaneously hypertensive and Wistar rats.
Regulation (Effects) of Gene_expression (sensitivity) of insulin in plasma associated with hypertension
3) Confidence 0.45 Published 2002 Journal Can. J. Physiol. Pharmacol. Section Title Doc Link 12450062 Disease Relevance 1.15 Pain Relevance 0.39
Effect of estrogen withdrawal on blood pressure and insulin resistance in sucrose-fed juvenile rats.
Regulation (Effect) of Gene_expression (resistance) of insulin in juvenile associated with insulin resistance and withdrawal
4) Confidence 0.44 Published 1996 Journal Am. J. Hypertens. Section Title Doc Link 8972891 Disease Relevance 0.63 Pain Relevance 0.17
The presence of insulin on the surface of SLN was not responsible for significant agglomeration, predicting absence of aggregation after oral administration.
Neg (not) Regulation (responsible) of Gene_expression (presence) of insulin
5) Confidence 0.44 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676823 Disease Relevance 0 Pain Relevance 0.05
This can explain why the MGL and MPW groups under short and long rehabilitated periods were able to decrease the glucose levels during the GTT in spite of low insulin production, suggesting an alteration in insulin sensitivity and production, which in a long term can lead to insulin resistance, visceral obesity and diabetes.
Regulation (alteration) of Gene_expression (production) of insulin in visceral associated with appetite loss, diabetes mellitus, metabolic syndrome and insulin resistance
6) Confidence 0.42 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2586678 Disease Relevance 1.19 Pain Relevance 0
Expression of the insulin gene is regulated by opioid peptides.
Regulation (regulated) of Gene_expression (Expression) of insulin associated with enkephalin and opioid
7) Confidence 0.37 Published 1990 Journal Biomed. Biochim. Acta Section Title Doc Link 2097989 Disease Relevance 0 Pain Relevance 0.82
Results suggest that chronic treatment with an antioxidant or an ACE inhibitor provides similar beneficial effects on sensory polyneuropathy, hypertension and insulin resistance in glucose-fed rats.
Regulation (effects) of Gene_expression (resistance) of insulin associated with neuropathy, hypertension and insulin resistance
8) Confidence 0.36 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18555989 Disease Relevance 1.04 Pain Relevance 0.30
We investigated the acute effects of thiopental anesthesia (4 mg/100 g, i.v.) on plasma glucose, insulin, triacylglycerol, and prolactin levels in rats treated with bromocriptine (BR) (0.4 mg/100 g body wt, i.p., for two weeks).
Spec (investigated) Regulation (effects) of Gene_expression (levels) of insulin in body associated with anesthesia
9) Confidence 0.35 Published 2003 Journal J. Pharmacol. Sci. Section Abstract Doc Link 12832843 Disease Relevance 0 Pain Relevance 0.41
It may be the case that over time, the process of ketosis has an inhibitory effect on insulin production and result in a dissociation between adiposity and plasma insulin levels.
Regulation (effect) of Gene_expression (production) of insulin in plasma associated with ketosis
10) Confidence 0.34 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2781796 Disease Relevance 0.36 Pain Relevance 0
The most remarkable finding in this study is the severe alterations observed in the MPW rats in blood glucose, insulin and glucagon levels.
Regulation (alterations) of Gene_expression (levels) of insulin in blood associated with appetite loss
11) Confidence 0.31 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2586678 Disease Relevance 0.99 Pain Relevance 0
cells and insulin production by the pancreas, only a few studies have explored the effects of malnutrition on ?
Regulation (explored) of Gene_expression (production) of insulin in pancreas associated with appetite loss
12) Confidence 0.31 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2586678 Disease Relevance 1.12 Pain Relevance 0
Effects of the K+ channel activators, RP 52891, cromakalim and diazoxide, on the plasma insulin level, plasma renin activity and blood pressure in rats.
Regulation (Effects) of in blood Gene_expression (level) of insulin in plasma
13) Confidence 0.30 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 1906538 Disease Relevance 0.20 Pain Relevance 0
The addition of naloxone (10(-5)M) during the infusion of acetylcholine abolished the stimulatory effect on BLI secretion in the absence of insulin, whereas in the presence of insulin naloxone did not alter cholinergically-induced BLI secretion.
Regulation (effect) of Neg (absence) Gene_expression (absence) of insulin associated with narcan
14) Confidence 0.30 Published 1986 Journal Neuropeptides Section Abstract Doc Link 3513044 Disease Relevance 0 Pain Relevance 0.74
These results point out that in eSS rats fasting hyperglycemia would be a later stage in the sequence of events from insulin resistance to overt diabetes, whilst the insulin resistance affects the lipid metabolism beforehand.
Regulation (affects) of Gene_expression (resistance) of insulin associated with hyperglycemia, diabetes mellitus and insulin resistance
15) Confidence 0.30 Published 2010 Journal Diabetol Metab Syndr Section Body Doc Link PMC2847988 Disease Relevance 1.29 Pain Relevance 0.03
The effects of the opioid peptides Met- and Leu-enkephalin on the expression of the insulin gene in isolated adult rat islets of Langerhans were examined.
Spec (examined) Regulation (effects) of Gene_expression (expression) of insulin in islets of Langerhans associated with enkephalin and opioid
16) Confidence 0.27 Published 1990 Journal Biomed. Biochim. Acta Section Abstract Doc Link 2097989 Disease Relevance 0 Pain Relevance 0.48
However, change in the fasting serum insulin levels during the 5 day feeding period was -0.186 ± 0.046 ng/ml in the CONT group, which was a 39% decrease compared to the initial level.
Regulation (change) of Gene_expression (levels) of insulin
17) Confidence 0.26 Published 2008 Journal Nutrition Research and Practice Section Body Doc Link PMC2788183 Disease Relevance 0.85 Pain Relevance 0
The main objective of the present study was to determine whether hypoglycemia as a consequence of insulin therapy in diabetes altered the binding parameters of Muscarinic M1, M3 receptors and gene expression of ?
Spec (whether) Regulation (consequence) of Gene_expression (therapy) of insulin associated with hypoglycemia and diabetes mellitus
18) Confidence 0.19 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2845573 Disease Relevance 1.34 Pain Relevance 0.20
synthesis until the molecular bases for its intriguing insulin-like effects
Regulation (effects) of Gene_expression (synthesis) of insulin
19) Confidence 0.18 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2323445 Disease Relevance 0.68 Pain Relevance 0.19
have demonstrated that the effects exerted by C-peptide on insulin action can
Regulation (effects) of Gene_expression (action) of insulin
20) Confidence 0.18 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2323445 Disease Relevance 0.16 Pain Relevance 0.08

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