INT174271

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Context Info
Confidence 0.15
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 6.85
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (F3) aging (F3) extracellular region (F3)
plasma membrane (F3) cytoplasm (F3)
Anatomy Link Frequency
coronary artery 1
blood 1
plaque 1
endothelium 1
respiratory 1
F3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 103 99.78 Very High Very High Very High
cytokine 19 98.08 Very High Very High Very High
ischemia 8 88.08 High High
Inflammatory response 11 75.96 Quite High
cva 28 73.76 Quite High
corticosteroid 4 61.00 Quite High
Angina 13 21.12 Low Low
metalloproteinase 8 5.00 Very Low Very Low Very Low
Tetrahydrobiopterin 6 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adult Respiratory Distress Syndrome 6 99.92 Very High Very High Very High
INFLAMMATION 126 99.78 Very High Very High Very High
Necrosis 13 98.68 Very High Very High Very High
Cancer 9 98.32 Very High Very High Very High
Malignant Neoplastic Disease 14 98.12 Very High Very High Very High
Infarction 2 98.04 Very High Very High Very High
Acute Renal Failure 3 98.00 Very High Very High Very High
Vasculitis 6 97.92 Very High Very High Very High
Myocardial Infarction 74 97.04 Very High Very High Very High
Atherosclerotic Plaque 16 96.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The chronic inflammation (with its associated tissue factor) along with endothelial cell dysfunction contributes to the prothrombotic state of the atherosclerotic plaque.
tissue factor Binding (associated) of in plaque associated with atherosclerotic plaque and inflammation
1) Confidence 0.15 Published 2004 Journal Cardiovasc Diabetol Section Body Doc Link PMC356925 Disease Relevance 1.32 Pain Relevance 0.14
AF: alkaline phosphatase; ALAT: alanine aminotransferase; APTT: activated partial thromboplastin time; ARDS: adult respiratory distress syndrome; ARF: acute renal failure; ASAT: aspartate aminotransferase; C-RP: C-reactive protein; CT: computed tomography; DIC: disseminated intravascular coagulation; ?
thromboplastin Binding (time) of in respiratory associated with acute renal failure, disseminated intravascular coagulation and adult respiratory distress syndrome
2) Confidence 0.05 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2584008 Disease Relevance 0.94 Pain Relevance 0.14
Because efficient hemostasis occurs only at vascular lesions where tissue factor is exposed and platelets rapidly aggregate, measurements of hemostatic markers at the site of vascular injury are more sensitive than those in venous blood in the assessment of local thrombotic reactions (13,14,19).
tissue factor Binding (aggregate) of in blood associated with vasculitis
3) Confidence 0.03 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2494657 Disease Relevance 1.63 Pain Relevance 0
rFVIIa acts at sites where the endothelium is damaged and tissue factor is released, implying a local mode of action. rFVIIa forms a complex with the tissue factor and then activates factor X and platelets, resulting in the local generation of thrombin and consecutively in the formation of a stable fibrin clot [11].
tissue factor Binding (complex) of in endothelium
4) Confidence 0.03 Published 2007 Journal BMC Infect Dis Section Body Doc Link PMC1876232 Disease Relevance 0.82 Pain Relevance 0.04
In accordance recent studies demonstrate, that MP linked tissue factor activity is associated to fibrinolysis failure in ST segment elevation infarction and is significantly elevated in the occluded coronary artery of STEMI patients [34,35].
tissue factor Binding (associated) of in coronary artery associated with infarction
5) Confidence 0.02 Published 2009 Journal Thromb J Section Body Doc Link PMC2714503 Disease Relevance 0.63 Pain Relevance 0.06
Also, interaction of tissue factor and P-selectin accelerates the rate and extent of fibrin formation [10].
tissue factor Binding (interaction) of
6) Confidence 0.01 Published 2003 Journal Thromb J Section Body Doc Link PMC179880 Disease Relevance 1.46 Pain Relevance 0.15

General Comments

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