INT174272

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Context Info
Confidence 0.14
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.06
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (F3) aging (F3) extracellular region (F3)
plasma membrane (F3) cytoplasm (F3)
Anatomy Link Frequency
platelet 4
white blood cells 2
plaque 2
F3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 69 97.84 Very High Very High Very High
Bile 7 83.44 Quite High
Inflammatory mediators 2 64.40 Quite High
Inflammatory marker 4 63.76 Quite High
Inflammatory response 10 61.96 Quite High
cytokine 17 59.64 Quite High
palliative 2 58.16 Quite High
corticosteroid 5 47.00 Quite Low
adenocard 1 38.08 Quite Low
rheumatoid arthritis 1 37.92 Quite Low
Disease Link Frequency Relevance Heat
Cystic Fibrosis 1 99.60 Very High Very High Very High
Streptococcus Infection 8 99.52 Very High Very High Very High
INFLAMMATION 89 97.84 Very High Very High Very High
Breast Cancer 1 96.80 Very High Very High Very High
Adhesions 19 96.48 Very High Very High Very High
Malignant Neoplastic Disease 8 95.64 Very High Very High Very High
Disseminated Intravascular Coagulation 27 94.72 High High
Increased Venous Pressure Under Development 16 93.48 High High
Acute Renal Failure 2 89.52 High High
Adult Respiratory Distress Syndrome 6 88.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The degree of tissue factor expression has been shown to correlate with metastatic potential and histological differentiation such that increased TF expression results an increased potential to metastasise and a more undifferentiated histological appearance [6,7].
Negative_regulation (degree) of Gene_expression (expression) of tissue factor
1) Confidence 0.14 Published 2005 Journal World J Surg Oncol Section Body Doc Link PMC1156959 Disease Relevance 1.08 Pain Relevance 0.06
Furthermore, the production of tissue factor or inhibition of tissue-factor-pathway-inhibitor (TFPI) activates the extrinsic coagulation pathway [2,14], while the simultaneous decreased production of prostacyclin induces vasoconstriction and platelet aggregation.
Negative_regulation (inhibition) of Gene_expression (production) of tissue factor in platelet associated with increased venous pressure under development
2) Confidence 0.10 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2987921 Disease Relevance 0.74 Pain Relevance 0
GT: gamma glutamyl transferase; ICU: Intensive Care Unit; MOF: multi organ failure; PEEP: positive end expiratory pressure; PTT: partial thromboplastin time; StrepTSS: streptococcal toxic shock syndrome; WBC: white blood cells

Consent

Negative_regulation (partial) of Gene_expression (time) of thromboplastin in white blood cells associated with streptococcus infection
3) Confidence 0.06 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2584008 Disease Relevance 0.83 Pain Relevance 0.09
Fenofibric acid has been shown to inhibit plasminogen activator inhibitor-1 and tissue factor expression on endothelial cells and macrophages.63 Fenofibrate also modulates platelet aggregation and endothelial dysfunction, via an incompletely elucidated molecular mechanism.64,65
Negative_regulation (inhibit) of Gene_expression (expression) of tissue factor in platelet
4) Confidence 0.03 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922314 Disease Relevance 0.68 Pain Relevance 0.07
Additional effects were observed: statins limit tissue factor expression [80], normalize fibrinolytic activity, reduce plaque inflammation and cause regression of human atheroesclerotic lesions [81], improve coronary endothelial function [82] and have antiinflammatory and antiproliferative effects [83].
Negative_regulation (limit) of Gene_expression (expression) of tissue factor in plaque associated with inflammation
5) Confidence 0.01 Published 2003 Journal Thromb J Section Body Doc Link PMC179880 Disease Relevance 0.73 Pain Relevance 0.08

General Comments

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