INT174273

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Context Info
Confidence 0.08
First Reported 2003
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.99
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (F2) extracellular space (F2) extracellular region (F2)
plasma membrane (F2)
Anatomy Link Frequency
platelet 2
F2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Restless leg syndrome 60 99.08 Very High Very High Very High
Inflammation 90 98.32 Very High Very High Very High
Inflammatory marker 6 94.00 High High
Inflammatory response 13 89.20 High High
aspirin 14 86.12 High High
cytokine 17 80.96 Quite High
chemokine 1 66.32 Quite High
Angina 4 46.96 Quite Low
Pain 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coagulation Disorder 5 99.74 Very High Very High Very High
Thrombosis 7 99.12 Very High Very High Very High
Increased Venous Pressure Under Development 70 99.08 Very High Very High Very High
INFLAMMATION 117 98.32 Very High Very High Very High
Stress 10 89.76 High High
Apoptosis 3 88.84 High High
Multiple Organ Failure 33 81.88 Quite High
Pancreatitis 44 81.04 Quite High
Atherosclerosis 31 79.12 Quite High
Rupture 1 78.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The obvious limitation is the fact that thrombin formation is also enhanced whenever APC generation is enhanced, and the question remains whether APC or other components of the activated coagulation pathways might be involved.
Positive_regulation (enhanced) of thrombin Binding (formation) of
1) Confidence 0.08 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 1.09 Pain Relevance 0.17
Exercise did result in increased TAT levels suggesting in-vivo thrombin generation in both patients with IC and healthy volunteers, but the effect in patients was immediate and more prolonged.
Positive_regulation (increased) of thrombin Binding (generation) of associated with restless leg syndrome
2) Confidence 0.03 Published 2006 Journal Thromb J Section Body Doc Link PMC1540420 Disease Relevance 0.70 Pain Relevance 0.65
Blood turbulence produces platelet and clotting activation, accelerates thrombin formation and promotes a mixed thrombus [14].
Positive_regulation (accelerates) of thrombin Binding (formation) of in platelet associated with coagulation disorder and thrombosis
3) Confidence 0.01 Published 2003 Journal Thromb J Section Body Doc Link PMC179880 Disease Relevance 1.20 Pain Relevance 0.21

General Comments

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