INT174277

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Context Info
Confidence 0.33
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 23
Total Number 23
Disease Relevance 8.08
Pain Relevance 3.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gopc) Golgi apparatus (Gopc) plasma membrane (Gopc)
cytoplasm (Gopc)
Anatomy Link Frequency
macrophages 4
plasma cell 2
nucleus 2
osteoclast 2
granule cells 2
Gopc (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 55 100.00 Very High Very High Very High
adenocard 51 99.78 Very High Very High Very High
qutenza 14 99.22 Very High Very High Very High
GABAergic 4 99.16 Very High Very High Very High
agonist 60 99.02 Very High Very High Very High
bDMF 9 98.46 Very High Very High Very High
Glutamate 61 94.84 High High
imagery 17 92.80 High High
gABA 9 86.64 High High
cytokine 28 86.36 High High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 50 100.00 Very High Very High Very High
Hypertrophy 5 100.00 Very High Very High Very High
Retina Disease 30 99.98 Very High Very High Very High
Infection 140 99.46 Very High Very High Very High
Shock 95 99.32 Very High Very High Very High
Disease 47 98.52 Very High Very High Very High
Myocardial Infarction 70 97.68 Very High Very High Very High
Insulin Resistance 26 95.60 Very High Very High Very High
Sprains And Strains 113 93.76 High High
Diabetes Mellitus 58 92.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cytotoxic NK activity against K562 cells increased in parallel with the increase in the E/T ratio (Fig. 3), with the 100 ?
Positive_regulation (increased) of Positive_regulation (increase) of Fig
1) Confidence 0.33 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2892347 Disease Relevance 0 Pain Relevance 0
Non-lethal infection with WR and Wyeth did not induce a significant increase of this subset (Fig. 5B).
Neg (not) Positive_regulation (induce) of Positive_regulation (increase) of Fig associated with infection
2) Confidence 0.33 Published 2007 Journal Virol J Section Body Doc Link PMC1810241 Disease Relevance 1.19 Pain Relevance 0
Retinal detachment induced an increase of utrophin immunolabeling in the inner limiting membrane (Fig. 1K, arrow and arrowhead).
Positive_regulation (induced) of Positive_regulation (increase) of Fig in inner limiting membrane associated with retina disease
3) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.17 Pain Relevance 0
The effect of HS+MES on insulin signaling is likely through the capacity of electrical signal to trigger the activation of Akt (Fig. 8, [8]) and of HS to up-regulate Hsp72, which in turn inhibits JNK and activates the insulin signaling pathway (Fig. 4C, Fig. 9 [24], [41]).
Positive_regulation (trigger) of Positive_regulation (activation) of Fig associated with shock
4) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 1.28 Pain Relevance 0.10
Exposure to synthesized perfluorosilane induced increased number of neutrophils, lymphocytes, and macrophages (Fig. 4b).
Positive_regulation (induced) of Positive_regulation (increased) of Fig in macrophages
5) Confidence 0.23 Published 2010 Journal Toxicological Sciences Section Body Doc Link PMC2886856 Disease Relevance 0.56 Pain Relevance 0.10
Implanting corticosterone implants for 48 hours led to an elevation in both hypothalamic AGRP and POMC mRNA (Fig. 6B).
Positive_regulation (led) of Positive_regulation (elevation) of Fig
6) Confidence 0.22 Published 2003 Journal BMC Physiol Section Body Doc Link PMC179893 Disease Relevance 0.25 Pain Relevance 0
We propose that entry into the plasma cell program results in the induction of the MHV68 immediate-early transcriptional activator RTA and subsequent activation of the virus replication cycle (Fig. 6E).
Positive_regulation (induction) of Positive_regulation (activation) of Fig in plasma cell
7) Confidence 0.22 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777334 Disease Relevance 0.16 Pain Relevance 0
It is thus likely that ACh stimulation activates the upregulated RhoA (Fig. 5), resulting in a greater phosphorylation of MLC (Fig. 6) and contraction of BSMs in AHR mice.
Positive_regulation (activates) of Positive_regulation (upregulated) of Fig
8) Confidence 0.19 Published 2005 Journal Respir Res Section Body Doc Link PMC545934 Disease Relevance 0.43 Pain Relevance 0.19
Surprisingly, anti-IL-2 treatment enhanced the accumulation of Clone 4 CD8+ T cell in the lymphoid tissue (Fig. 3B).
Positive_regulation (enhanced) of Positive_regulation (accumulation) of Fig in lymphoid tissue
9) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939396 Disease Relevance 0.58 Pain Relevance 0
Absence of IL-1R1 signaling leads to attenuated hypertrophy of astrocytes and delayed induction of GFAP (Fig. 1 and 2)
Positive_regulation (leads) of Positive_regulation (induction) of Fig in astrocytes associated with hypertrophy
10) Confidence 0.17 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.26 Pain Relevance 0.11
Addition of 100 ng/ml recombinant brain derived neurotrophic factor (BDNF), which also induces the GABAergic phenotype in granule cells in vivo [30], led to a similar upregulation of GAD67 (Fig. 3f).
Positive_regulation (led) of Positive_regulation (upregulation) of Fig in granule cells associated with gabaergic and bdmf
11) Confidence 0.16 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1849968 Disease Relevance 0.08 Pain Relevance 0.52
Using two different subtype-specific adenosine receptor blockers, we concluded that the adenosine effect is mediated by activation of A1 receptors (Fig. 1f).
Positive_regulation (mediated) of Positive_regulation (activation) of Fig associated with adenocard
12) Confidence 0.16 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072913 Disease Relevance 0.06 Pain Relevance 0.63
Flow cytometric analysis indeed displayed a significant increase of LacZ+ cells in both Sca-1+ and CD31+ cell populations, parallel with an increase in total Sca+ and CD31+ cell numbers (Fig. 5a–d).
Positive_regulation (increase) of Positive_regulation (increase) of Fig
13) Confidence 0.14 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916122 Disease Relevance 0.43 Pain Relevance 0
By testing serum samples during the course of disease, we found that the osteoclast-specific TRAP 5b levels were significantly increased after MDL-1 receptor activation (Fig. 4 C).
Positive_regulation (increased) of Positive_regulation (activation) of Fig in osteoclast associated with disease
14) Confidence 0.14 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0.34 Pain Relevance 0.18
We activated TRPV1 by applying brief pulses of the specific agonist capsaicin, and tested the effect of thrombin in enhancing TRPV1 activation (Fig. 4F).
Positive_regulation (enhancing) of Positive_regulation (activation) of Fig associated with qutenza and agonist
15) Confidence 0.13 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0.07 Pain Relevance 0.36
An important clue from our current studies is the discovery that as a-Syn levels increase in MN9D cells, Ser(P)-129 levels also increased (Fig. 5).
Positive_regulation (increase) of Positive_regulation (increased) of Fig
16) Confidence 0.11 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0.30 Pain Relevance 0
B-p65 cellular abundance (Fig. 3A, second panel) and a clear increase in Nrf2 (Fig. 3B, second panel) accumulation in the nucleus after 1 h of DNCB treatment.
Positive_regulation (increase) of Positive_regulation (accumulation) of Fig in nucleus
17) Confidence 0.11 Published 2010 Journal Biochemical Pharmacology Section Body Doc Link PMC2884179 Disease Relevance 0.07 Pain Relevance 0.15
In our experimental conditions, photothrombotic ischemia leads to PARP-1 activation at 4 h and 24 h after the onset of ischemia as evidenced by a marked PAR immunostaining, the enzymatic product of PARP-1 (Fig. 3A).
Positive_regulation (leads) of Positive_regulation (activation) of Fig associated with ischemia
18) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779656 Disease Relevance 0.73 Pain Relevance 0.32
Exposure to synthesized perfluorosilane induced increased number of neutrophils, lymphocytes, and macrophages (Fig. 4b).
Positive_regulation (induced) of in lymphocytes Positive_regulation (increased) of Fig in macrophages
19) Confidence 0.08 Published 2010 Journal Toxicological Sciences Section Body Doc Link PMC2886856 Disease Relevance 0.56 Pain Relevance 0.10
Exposure to synthesized perfluorosilane induced increased number of neutrophils, lymphocytes, and macrophages (Fig. 4b).
Positive_regulation (induced) of in neutrophils Positive_regulation (increased) of Fig in macrophages
20) Confidence 0.08 Published 2010 Journal Toxicological Sciences Section Body Doc Link PMC2886856 Disease Relevance 0.56 Pain Relevance 0.10

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