INT174281

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Context Info
Confidence 0.41
First Reported 2003
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.71
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Agrp) extracellular region (Agrp) Golgi apparatus (Agrp)
Anatomy Link Frequency
plasma 6
hypothalamus 2
Agrp (Mus musculus)
Pain Link Frequency Relevance Heat
medulla 27 100.00 Very High Very High Very High
vagus nerve 7 91.20 High High
Cholecystokinin 8 90.64 High High
Endogenous opioid 2 82.28 Quite High
antagonist 10 80.56 Quite High
parabrachial 1 48.96 Quite Low
Locus ceruleus 2 42.72 Quite Low
Eae 1 27.72 Quite Low
Central nervous system 15 23.44 Low Low
Neuropeptide 4 13.80 Low Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 99 99.28 Very High Very High Very High
Body Weight 57 98.96 Very High Very High Very High
Anorexia 14 88.64 High High
Obesity 72 33.92 Quite Low
Sprains And Strains 5 19.72 Low Low
Appetite Loss 10 5.00 Very Low Very Low Very Low
Metabolic Syndrome 6 5.00 Very Low Very Low Very Low
Hyperphagia 6 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low
Weight Gain 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In turn, as with fasting, the reduction of plasma leptin could be the cause of the elevation of hypothalamic AGRP and NPY mRNA, as well as the reduction of hypothalamic POMC mRNA.
Positive_regulation (cause) of Positive_regulation (elevation) of AGRP in plasma
1) Confidence 0.41 Published 2003 Journal BMC Physiol Section Body Doc Link PMC179893 Disease Relevance 0.16 Pain Relevance 0
Finally, elevated plasma corticosterone is both necessary and sufficient for the induction of hypothalamic AGRP mRNA with fasting and diabetes.



Positive_regulation (sufficient) of Positive_regulation (induction) of AGRP mRNA in plasma associated with diabetes mellitus
2) Confidence 0.38 Published 2003 Journal BMC Physiol Section Abstract Doc Link PMC179893 Disease Relevance 0.68 Pain Relevance 0
Finally, elevated plasma corticosterone is both necessary and sufficient for the induction of hypothalamic AGRP mRNA with fasting and diabetes.



Positive_regulation (necessary) of Positive_regulation (induction) of AGRP mRNA in plasma associated with diabetes mellitus
3) Confidence 0.38 Published 2003 Journal BMC Physiol Section Abstract Doc Link PMC179893 Disease Relevance 0.68 Pain Relevance 0
This is associated with activation on neurones in the NTS, as well as increased AgRP and decreased POMC mRNA expression in the hypothalamus [92].
Positive_regulation (activation) of Positive_regulation (increased) of AgRP in hypothalamus associated with medulla
4) Confidence 0.37 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.19 Pain Relevance 0.91

General Comments

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