INT174290

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Context Info
Confidence 0.50
First Reported 2003
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.47
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lep, Pomc) signal transduction (Lep, Pomc) extracellular region (Lep, Pomc)
intracellular (Lep) cell-cell signaling (Pomc) cytoplasm (Pomc)
Anatomy Link Frequency
arcuate nucleus 1
Lep (Mus musculus)
Pomc (Mus musculus)
Pain Link Frequency Relevance Heat
Neurotransmitter 2 48.24 Quite Low
amygdala 8 45.96 Quite Low
Nucleus accumbens 5 45.44 Quite Low
medulla 27 25.12 Quite Low
Central nervous system 15 5.00 Very Low Very Low Very Low
antagonist 10 5.00 Very Low Very Low Very Low
agonist 10 5.00 Very Low Very Low Very Low
Cholecystokinin 8 5.00 Very Low Very Low Very Low
gABA 8 5.00 Very Low Very Low Very Low
vagus nerve 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 33 98.64 Very High Very High Very High
Body Weight 21 25.00 Low Low
Obesity 62 5.00 Very Low Very Low Very Low
Anorexia 14 5.00 Very Low Very Low Very Low
Appetite Loss 10 5.00 Very Low Very Low Very Low
Sprains And Strains 5 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low
Hyperphagia 4 5.00 Very Low Very Low Very Low
Weight Gain 4 5.00 Very Low Very Low Very Low
Syndrome 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
POMC neurones in the arcuate nucleus, which express LEPRB, are activated by leptin.
leptin Positive_regulation (activated) of POMC in arcuate nucleus
1) Confidence 0.50 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0 Pain Relevance 0
Fasting and diabetes are characterized by elevated glucocorticoids and reduced insulin, leptin, elevated hypothalamic AGRP and NPY mRNA, and reduced hypothalamic POMC mRNA.
leptin Positive_regulation (elevated) of POMC mRNA associated with diabetes mellitus
2) Confidence 0.09 Published 2003 Journal BMC Physiol Section Abstract Doc Link PMC179893 Disease Relevance 0.47 Pain Relevance 0

General Comments

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