INT174354

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Context Info
Confidence 0.35
First Reported 2003
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 0.87
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Avpr2) plasma membrane (Avpr2) signal transducer activity (Avpr2)
Anatomy Link Frequency
vomeronasal organ 3
testis 1
neurons 1
brain 1
kidney 1
Avpr2 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 24 5.00 Very Low Very Low Very Low
antagonist 17 5.00 Very Low Very Low Very Low
medulla 16 5.00 Very Low Very Low Very Low
cytokine 13 5.00 Very Low Very Low Very Low
Kinase C 12 5.00 Very Low Very Low Very Low
depression 10 5.00 Very Low Very Low Very Low
amygdala 9 5.00 Very Low Very Low Very Low
Neuropeptide 9 5.00 Very Low Very Low Very Low
dexamethasone 9 5.00 Very Low Very Low Very Low
agonist 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 100 98.72 Very High Very High Very High
Aggression 30 95.32 Very High Very High Very High
Stress 108 89.00 High High
Polyuria 1 41.80 Quite Low
Diabetes Insipidus 1 40.72 Quite Low
Pressure Volume 2 Under Development 2 12.08 Low Low
Sprains And Strains 42 5.00 Very Low Very Low Very Low
Depression 12 5.00 Very Low Very Low Very Low
Anxiety Disorder 12 5.00 Very Low Very Low Very Low
Pain 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The distribution and function of Avp receptors is not limited to those sites mentioned above and all receptors except the Avpr2 are expressed in the brain.
Gene_expression (expressed) of Avpr2 in brain
1) Confidence 0.35 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.26 Pain Relevance 0
The antidiuretic effect of vasopressin is achieved through the GPCR member, V2 receptor (V2R), which is expressed at the basolateral side of the tubules and the collecting ducts of the kidney (Lolait et al. 1992; Knepper, 1997; Robben et al. 2006).
Gene_expression (expressed) of V2R in kidney
2) Confidence 0.22 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0 Pain Relevance 0
2-microglobulin complex is essential for V2R protein expression on the dendritic surface of neurons in the vomeronasal organ.
Gene_expression (expression) of V2R in vomeronasal organ
3) Confidence 0.17 Published 2003 Journal Genome Biol Section Body Doc Link PMC193622 Disease Relevance 0.12 Pain Relevance 0
Importantly, a given V2R gene seems to be coexpressed with a particular MHC gene, and, in the vomeronasal organ, the MHC proteins and ?
Gene_expression (coexpressed) of V2R gene in vomeronasal organ
4) Confidence 0.17 Published 2003 Journal Genome Biol Section Body Doc Link PMC193622 Disease Relevance 0 Pain Relevance 0
2-microglobulin complex for cell-surface expression of V2R proteins was further confirmed in tissue-culture experiments.
Gene_expression (expression) of V2R
5) Confidence 0.17 Published 2003 Journal Genome Biol Section Body Doc Link PMC193622 Disease Relevance 0.14 Pain Relevance 0
When V2R genes are expressed in a testis cell line, V2R receptor proteins remain inside the cell, but when the cells are cotransfected with MHC and ?
Gene_expression (expressed) of V2R in testis
6) Confidence 0.14 Published 2003 Journal Genome Biol Section Body Doc Link PMC193622 Disease Relevance 0.15 Pain Relevance 0
Moreover, each of these MHC genes is differentially expressed in a subset of neurons in the vomeronasal organ that also express one of the V2R genes.
Gene_expression (express) of V2R in neurons
7) Confidence 0.14 Published 2003 Journal Genome Biol Section Body Doc Link PMC193622 Disease Relevance 0 Pain Relevance 0
2-microglobulin knockout mice, no specific function has yet been assigned to any of the V2R or MHC class I receptors expressed in the vomeronasal organ.


Gene_expression (expressed) of V2R in vomeronasal organ associated with targeted disruption
8) Confidence 0.14 Published 2003 Journal Genome Biol Section Body Doc Link PMC193622 Disease Relevance 0.19 Pain Relevance 0

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