INT17441

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Context Info
Confidence 0.78
First Reported 1991
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.60
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (LTA4H) peptidase activity (LTA4H) small molecule metabolic process (LTA4H)
nucleolus (LTA4H) nucleus (LTA4H) cytoplasm (LTA4H)
LTA4H (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 10 77.84 Quite High
cINOD 7 77.08 Quite High
Inflammatory response 1 66.08 Quite High
Arthritis 1 25.00 Low Low
alcohol 1 25.00 Low Low
aspirin 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 11 77.84 Quite High
Autoimmune Disease 1 76.48 Quite High
Disease 1 75.00 Quite High
Cardiovascular Disease 1 38.16 Quite Low
Asthma 2 30.88 Quite Low
Arthritis 1 25.00 Low Low
Inflammatory Bowel Disease 1 25.00 Low Low
Respiratory Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Leukotriene A4 hydrolase (LTA4H) is a ubiquitously expressed enzyme that catalyzes the final step in the synthesis of leukotriene B4 (LTB4), a potent proinflammatory lipid mediator derived from arachidonic acid.
Gene_expression (expressed) of LTA4H
1) Confidence 0.78 Published 2009 Journal Curr Opin Investig Drugs Section Abstract Doc Link 19876785 Disease Relevance 0.37 Pain Relevance 0.11
The formation of the leukotriene, LTA4, is catalyzed by a 5-lipoxygenase possessing both lipoxygenase and LTA4-synthase activities.
Gene_expression (possessing) of LTA4
2) Confidence 0.57 Published 1991 Journal Z Rheumatol Section Abstract Doc Link 1907059 Disease Relevance 0.22 Pain Relevance 0.15
It is possible that the putative LTA4 hydrolase (LTA4H), which is a bi-functional enzyme in mammals, having both LTA4 hydrolase and aminopeptidase activity, only has aminopeptidase activity in daphnids as has been reported in Caenorhabditis elegans [29].
Gene_expression (hydrolase) of LTA4H
3) Confidence 0.10 Published 2008 Journal Front Zool Section Body Doc Link PMC2483973 Disease Relevance 0 Pain Relevance 0

General Comments

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