INT174419

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Context Info
Confidence 0.55
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 4.68
Pain Relevance 2.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cxcr1) plasma membrane (Cxcr1) signal transducer activity (Cxcr1)
Anatomy Link Frequency
skin 1
neutrophils 1
Cxcr1 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 168 100.00 Very High Very High Very High
rheumatoid arthritis 306 99.56 Very High Very High Very High
Osteoarthritis 150 97.56 Very High Very High Very High
Inflammation 89 97.12 Very High Very High Very High
Arthritis 21 93.52 High High
psoriasis 3 90.56 High High
cytokine 26 50.48 Quite High
ischemia 9 50.00 Quite Low
metalloproteinase 9 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 306 99.56 Very High Very High Very High
Psoriasis 6 98.24 Very High Very High Very High
Disease 41 97.88 Very High Very High Very High
Osteoarthritis 150 97.56 Very High Very High Very High
INFLAMMATION 94 97.12 Very High Very High Very High
Arthritis 24 93.52 High High
Hyperplasia 9 93.44 High High
Injury 66 88.40 High High
Cv Unclassified Under Development 9 50.00 Quite Low
Reperfusion Injury 1 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another group demonstrated that mRNA levels of the CXCL8 receptors CXCR1 and CXCR2 were 10-fold elevated in injured psoriatic epidermis as compared with normal skin, suggesting a role for high expression of CXCL8 receptors in epidermal hyperplasia, leukocyte infiltration, and increased HLA-DR expression in psoriasis [7,32].
Transcription (levels) of CXCR1 in skin associated with psoriasis and hyperplasia
1) Confidence 0.55 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 0.77 Pain Relevance 0.39
Elevated protein levels in RA synovial tissue were detected for CXCR1 and CXCR3 by Western blotting.
Transcription (detected) of CXCR1 associated with rheumatoid arthritis
2) Confidence 0.41 Published 2003 Journal Arthritis Res Ther Section Abstract Doc Link PMC193722 Disease Relevance 1.51 Pain Relevance 0.68
Similarly, levels of CXCR1 and CXCR2 transcripts were increased by 10-fold (P < 0.05) and approximately sixfold (P < 0.05) in RA versus OA synovial samples (Fig. 2b), respectively.
Transcription (levels) of CXCR1 associated with rheumatoid arthritis and osteoarthritis
3) Confidence 0.41 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.38 Pain Relevance 0.80
The influx of neutrophils occurred along with the early peak of CXC chemokine mRNA expression.
Transcription (expression) of CXC chemokine in neutrophils associated with chemokine
4) Confidence 0.02 Published 2010 Journal International Immunology Section Body Doc Link PMC2877810 Disease Relevance 1.02 Pain Relevance 0.65

General Comments

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