INT17442

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Context Info
Confidence 0.75
First Reported 1983
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 110
Total Number 110
Disease Relevance 51.55
Pain Relevance 18.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ALOX5) nuclear envelope (ALOX5) small molecule metabolic process (ALOX5)
oxidoreductase activity (ALOX5) nucleus (ALOX5) cytoplasm (ALOX5)
Anatomy Link Frequency
endothelium 6
chondrocytes 4
osteoblasts 4
neutrophils 3
internal 2
ALOX5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 3024 100.00 Very High Very High Very High
cINOD 386 99.96 Very High Very High Very High
antagonist 162 99.72 Very High Very High Very High
Inflammation 945 99.60 Very High Very High Very High
licofelone 153 99.14 Very High Very High Very High
aspirin 319 99.04 Very High Very High Very High
cytokine 86 98.00 Very High Very High Very High
COX2 18 97.68 Very High Very High Very High
corticosteroid 91 94.76 High High
Inflammatory response 91 94.32 High High
Disease Link Frequency Relevance Heat
Osteoarthritis 3115 100.00 Very High Very High Very High
Death 105 100.00 Very High Very High Very High
INFLAMMATION 1202 99.84 Very High Very High Very High
Pancreatic Cancer 206 99.84 Very High Very High Very High
Cancer 411 99.78 Very High Very High Very High
Nasal Polyps 62 99.68 Very High Very High Very High
Occupational Lung Diseases 49 99.46 Very High Very High Very High
Hypotension 16 99.36 Very High Very High Very High
Asthma 683 99.08 Very High Very High Very High
Aging 18 99.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Leukocyte-specific expression of human 15-LO has also been shown to reduce inflammation and atherosclerosis in rabbits [27, 28], most likely due to the generation of lipoxins from the dual action of 5-LO and 15-LO on arachidonic acid substrate in the leukocyte [29–31].
Gene_expression (expression) of 5-LO in leukocyte associated with inflammation and atherosclerosis
1) Confidence 0.75 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2878676 Disease Relevance 0.68 Pain Relevance 0.17
These mutations result in a decreased expression of the 5-LOX gene.
Gene_expression (expression) of 5-LOX
2) Confidence 0.75 Published 2000 Journal Med. Hypotheses Section Abstract Doc Link 10790729 Disease Relevance 0.79 Pain Relevance 0.14
The 15-lipoxygenase from soya bean has been claimed to represent a rapid assay procedure for drugs and chemical agents that inhibit other lipoxygenase products (Kingston, 1981).
Gene_expression (products) of lipoxygenase
3) Confidence 0.67 Published 1983 Journal Br. J. Dermatol. Section Abstract Doc Link 6407509 Disease Relevance 0.24 Pain Relevance 0.20
Leukotrienes are biosynthesised de novo via 5-lipoxygenase from cell membrane phospholipids in mast cells, eosinophils, neutrophils, basophils and alveolar macrophages [26].
Gene_expression (biosynthesised) of 5-lipoxygenase in neutrophils
4) Confidence 0.65 Published 2009 Journal Respir Res Section Body Doc Link PMC2696438 Disease Relevance 0.42 Pain Relevance 0.09
MK866 blocks the 5-lipoxygenase pathway of arachidonic acid
Gene_expression (pathway) of 5-lipoxygenase
5) Confidence 0.65 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 1.29 Pain Relevance 0.11
No association, however, was found between the LTC4S-444A > C polymorphism and the phenotype of NSAID-induced isolated periorbital angioedema in Spanish35 or Korean populations.36 We also investigated the genetic polymorphisms of candidate genes encoding enzymes which are involved in leukotriene synthesis in a Korean population.36 Of the eight SNPs in the four leukotriene-related genes, ALOX5, ALOX5AP (5-lipoxygenase activating protein), and PTGS2 (cyclooxygenase 2), as well as the polymorphism of ALOX5 at position-1708 G > A, showed a significant difference in genotypic frequency between AIU and AIA.
Gene_expression (synthesis) of ALOX5 associated with asthma, pressure and volume under development, cinod and cox2
6) Confidence 0.65 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687575 Disease Relevance 1.49 Pain Relevance 0.34
The ALOX5 SNP rs1369214 is only 360?
Gene_expression (rs1369214) of ALOX5
7) Confidence 0.63 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2878676 Disease Relevance 0 Pain Relevance 0
Four lipoxygenase pathway variants contributed to variation in CorCP—one in ALOX5 (rs2115819), one in ALOX12 (rs2271316), and two in ALOX5AP (rs9506352 and rs4769060).
Gene_expression (two) of ALOX5
8) Confidence 0.63 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2878676 Disease Relevance 0.43 Pain Relevance 0
Four lipoxygenase pathway variants contributed to variation in CorCP—one in ALOX5 (rs2115819), one in ALOX12 (rs2271316), and two in ALOX5AP (rs9506352 and rs4769060).
Gene_expression (one) of ALOX5
9) Confidence 0.63 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2878676 Disease Relevance 0.42 Pain Relevance 0
Two additional ALOX5 SNPs (rs3780901 in intron 4 and rs1059696 in intron 7) were identified that were near the ALOX5 rs3780901 SNP.
Gene_expression (rs3780901) of ALOX5
10) Confidence 0.63 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2878676 Disease Relevance 0 Pain Relevance 0
bp from rs2115819, while the ALOX5 SNP rs11239524 is ~11?
Gene_expression (rs11239524) of ALOX5
11) Confidence 0.63 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2878676 Disease Relevance 0 Pain Relevance 0
Two additional ALOX5 SNPs (rs3780901 in intron 4 and rs1059696 in intron 7) were identified that were near the ALOX5 rs3780901 SNP.
Gene_expression (rs3780901) of ALOX5
12) Confidence 0.63 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2878676 Disease Relevance 0 Pain Relevance 0
As the lipoxygenase pathway is the only operant metabolic system available for arachidonic acid in the presence of aspirin and non-steroidal anti-inflammatory drugs--and as the nonsteroidal anti-inflammatory drugs themselves stimulate mucus production--it is possible that the mechanism responsible for mucus release in aspirin-sensitive asthmatics is the formation of these lipoxygenase products.
Gene_expression (products) of lipoxygenase associated with aspirin, inflammation, cinod and occupational lung diseases
13) Confidence 0.59 Published 1983 Journal J Asthma Section Abstract Doc Link 6408056 Disease Relevance 0.52 Pain Relevance 0.39
The effect of prostaglandins, nonsteroidal anti-inflammatory drugs, lipoxygenase products of arachidonic acid, and other mucus-stimulating and mucus-inhibiting agents was studied.
Gene_expression (products) of lipoxygenase associated with inflammation and cinod
14) Confidence 0.59 Published 1983 Journal J Asthma Section Abstract Doc Link 6408056 Disease Relevance 0.30 Pain Relevance 0.27
In 221 patients with mild-to-moderate asthma treated with an ALOX5 inhibitor, ABT-761 (n = 114), or placebo (n = 107), 64 patients (among receiving active treatment) with at least one wild-type allele of the ALOX5 promoter locus had greater improvement in FEV1 than the 10 patients without any wild-type alleles (18.8% improvement vs. 1.1% decline, P < 0.0001).[34] In a corroborating study involving the leukotriene receptor antagonist zafirlukast, patients with no wild-type alleles had a 2.3% decrease in FEV1, whereas 44 subjects with two wild-type alleles and 19 subjects with at least one wild-type allele had improvements in FEV1 of 9.1 and 12.8%, respectively.[35]
Gene_expression (allele) of ALOX5 associated with asthma and antagonist
15) Confidence 0.58 Published 2010 Journal Indian Journal of Human Genetics Section Body Doc Link PMC3009420 Disease Relevance 0.43 Pain Relevance 0.08
Human AMs can generate both 5-lipoxygenase and 15-lipoxygenase derived eicosanoids, including LTB4 and LXA4, from endogenous sources of arachidonic acid[13].
Gene_expression (generate) of 5-lipoxygenase
16) Confidence 0.58 Published 2010 Journal Respir Res Section Body Doc Link PMC2894769 Disease Relevance 1.03 Pain Relevance 0.24
This suggested a predominant role for arachidonate lipoxygenase products.
Gene_expression (products) of lipoxygenase
17) Confidence 0.57 Published 1986 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 3098393 Disease Relevance 0.07 Pain Relevance 0.08
The cellular source of lipoxygenase may be a critical determinant of atherosclerosis; hence, lipoxygenase pathways, their components, and their genetic determinants may be central to understanding the development of human atherosclerosis and CVD risk.
Gene_expression (source) of lipoxygenase associated with cardiovascular disease and atherosclerosis
18) Confidence 0.57 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2878676 Disease Relevance 1.11 Pain Relevance 0.11
In PLT, orpanoxin (100 mumols/l) inhibited formation of cyclo-oxygenase products (thromboxanes, prostaglandins, and 12-L-hydroxy-5,8,10-heptadecatrienoic acid) and increased synthesis of the lipoxygenase product, 12S-hydroxy-5,8-cis,10-trans,14-cis-eicosatetraenoic acid.
Gene_expression (synthesis) of lipoxygenase
19) Confidence 0.56 Published 1988 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 3152163 Disease Relevance 0.07 Pain Relevance 0.18
of the gene), one in ALOX5 (rs2115819, P = .090, intron 3), and two in ALOX5AP (rs9506352, P = .097, intron 2; rs4769060, P = .073, intron 4).
Gene_expression (one) of ALOX5
20) Confidence 0.55 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2878676 Disease Relevance 0.12 Pain Relevance 0

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