INT174420

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Context Info
Confidence 0.20
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.92
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Cd74) signal transduction (Cd74) Golgi apparatus (Cd74)
endoplasmic reticulum (Cd74) plasma membrane (Cd74) protein complex assembly (Cd74)
Anatomy Link Frequency
skin 2
keratinocytes 2
Cd74 (Mus musculus)
Pain Link Frequency Relevance Heat
psoriasis 2 99.84 Very High Very High Very High
Arthritis 14 98.80 Very High Very High Very High
rheumatoid arthritis 204 89.60 High High
chemokine 59 88.64 High High
Inflammation 48 78.64 Quite High
cytokine 25 69.04 Quite High
Osteoarthritis 100 15.04 Low Low
alcohol 3 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Psoriasis 4 99.84 Very High Very High Very High
Hyperplasia 6 99.40 Very High Very High Very High
Arthritis 16 98.80 Very High Very High Very High
Disease 28 90.72 High High
Rheumatoid Arthritis 204 89.60 High High
Cancer 76 84.08 Quite High
INFLAMMATION 48 78.64 Quite High
Triploidy 2 75.60 Quite High
Skin Cancer 10 63.80 Quite High
Rhinitis 1 43.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
EGFr, c-Kit, and CD74 staining also showed an increased mean fluorescence intensity, whereas IL-13R?
Positive_regulation (whereas) of Gene_expression (staining) of CD74
1) Confidence 0.20 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2841166 Disease Relevance 0.42 Pain Relevance 0
Another group demonstrated that mRNA levels of the CXCL8 receptors CXCR1 and CXCR2 were 10-fold elevated in injured psoriatic epidermis as compared with normal skin, suggesting a role for high expression of CXCL8 receptors in epidermal hyperplasia, leukocyte infiltration, and increased HLA-DR expression in psoriasis [7,32].
Positive_regulation (increased) of Gene_expression (expression) of HLA-DR in skin associated with psoriasis and hyperplasia
2) Confidence 0.06 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 0.89 Pain Relevance 0.46
CXCL8 was shown to induce the expression of HLA-DR and to be chemotactic and mitogenic for keratinocytes [30,31].
Positive_regulation (induce) of Gene_expression (expression) of HLA-DR in keratinocytes
3) Confidence 0.04 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 0.61 Pain Relevance 0.35

General Comments

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