INT174422

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Context Info
Confidence 0.47
First Reported 2003
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 24
Total Number 24
Disease Relevance 26.09
Pain Relevance 8.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cxcr3) plasma membrane (Cxcr3) signal transducer activity (Cxcr3)
Anatomy Link Frequency
T cells 6
lymph node 2
mast cells 2
mononuclear cells 2
macrophages 1
Cxcr3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 457 99.90 Very High Very High Very High
chemokine 652 99.70 Very High Very High Very High
Osteoarthritis 50 99.48 Very High Very High Very High
rheumatoid arthritis 109 99.28 Very High Very High Very High
interstitial cystitis 451 96.64 Very High Very High Very High
Central nervous system 54 92.56 High High
cytokine 248 91.36 High High
Crohn's disease 86 90.92 High High
Multiple sclerosis 136 86.48 High High
Inflammatory response 23 79.92 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 468 99.90 Very High Very High Very High
Cystitis 770 99.80 Very High Very High Very High
Osteoarthritis 50 99.48 Very High Very High Very High
Rheumatoid Arthritis 110 99.28 Very High Very High Very High
Disease Progression 40 99.04 Very High Very High Very High
Pulmonary Disease 107 98.76 Very High Very High Very High
Infection 404 98.20 Very High Very High Very High
Bacillus Anthracis Infection 104 98.16 Very High Very High Very High
Mycobacterial Infection 152 97.48 Very High Very High Very High
Granuloma 8 97.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, the present study presents a scenario where CYP induction leads to increased numbers of both systemic and mucosal mast cells, partially through CXCL10-CXCR3 interactions.
CXCR3 Binding (interactions) of in mast cells
1) Confidence 0.47 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.94 Pain Relevance 0.46
These data suggest that direct ligand-mediated effects not associated with CXCR3 contribute to limiting disease progression in this model of pulmonary infection.
CXCR3 Binding (associated) of associated with infection and disease progression
2) Confidence 0.38 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2987825 Disease Relevance 0.80 Pain Relevance 0.08
In the present study, we investigated the consequences of selectively neutralizing CXCL9, CXCL10, and/or CXCL11 during pulmonary B. anthracis infection, and whether potential ligand-mediated contributions to host defense were independent of interactions with CXCR3.
CXCR3 Binding (interactions) of associated with infection
3) Confidence 0.38 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2987825 Disease Relevance 0.37 Pain Relevance 0.11
These chemokines stimulate and attract CXCR3+ monocytes/macrophages, T cells, NK cells, mast cells and dendritic cells.
CXCR3 Binding (attract) of in dendritic cells associated with chemokine
4) Confidence 0.36 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.67 Pain Relevance 0.60
These clinical trends were consistent with CYP-induced cystitis in mice; CXCR3 ligands were elevated in mouse serum as well as urinary bladder and iliac lymph node lymphocytes.
CXCR3 Binding (ligands) of in lymph node associated with cystitis
5) Confidence 0.36 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.19 Pain Relevance 0.41
For example, CXCL9, CXCL10, and CXCL11 bind to a common receptor, CXCR3.
CXCR3 Binding (example) of
6) Confidence 0.36 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.75 Pain Relevance 0.61
Increased CXCR3 mRNA expression within synovial tissue from RA versus OA patients is reflected by higher CXCR3/TCR-?
CXCR3 Binding (higher) of associated with rheumatoid arthritis and osteoarthritis
7) Confidence 0.35 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.75 Pain Relevance 0.92
CXCL10 blockade reduced the number of CD4+ T cells at this effector site, most likely by inhibiting chemotaxis and activation via CXCR3 interactions.
CXCR3 Binding (interactions) of in T cells
8) Confidence 0.35 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.60 Pain Relevance 0.22
Environmental (e.g., acrolein) or pathogenic (e.g., Escherichia coli) insults induce epithelial cells to increase their expression of CXCL10 [55], suggesting the mucosa participates in modulating T cell-mediated inflammation via CXCR3-CXCR3 ligand interactions.
CXCR3-CXCR3 Binding (interactions) of in T cell associated with inflammation
9) Confidence 0.35 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.28 Pain Relevance 0.20
These results demonstrate the ability of the interferon-inducible ELR- CXC chemokines, in particular CXCL9, to contribute directly to host defense through activities not associated with CXCR3.
CXCR3 Binding (associated) of associated with chemokine
10) Confidence 0.29 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2987825 Disease Relevance 0.40 Pain Relevance 0.25
While the observations reported here are consistent with direct antimicrobial effects similar to those found in vitro, they do not preclude ligand-mediated immunomodulatory activity; CXCL9 has recently been reported to induce gene transcription and chemokine production in peripheral blood mononuclear cells, independent of interactions with CXCR3 [47].
CXCR3 Binding (interactions) of in mononuclear cells associated with chemokine
11) Confidence 0.29 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2987825 Disease Relevance 0.71 Pain Relevance 0.14
DCs can be found in the intestinal mucosal [30] and have also been shown to produce and respond to CXCR3 ligands [31].
CXCR3 Binding (ligands) of
12) Confidence 0.28 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 0.55 Pain Relevance 0.09
In a recent study, mature DC-derived CXCR3 ligands were shown to be essential in Th1 cell retention in draining lymph nodes and to optimize Th1-mediated immune responses [33].
CXCR3 Binding (ligands) of in lymph nodes
13) Confidence 0.28 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 0.37 Pain Relevance 0.07
+ CD4+ and CD8+ T cells along with similar cells from PP that produce CXCR3 ligands as well as MLN (inductive site) IFN-?
CXCR3 Binding (ligands) of in T cells
14) Confidence 0.28 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 0.52 Pain Relevance 0.15
R deficient mice may be linked to a defective production of CXCR3 ligands CXCL9, 10, 11, essential for T cell migration to inflamed tissues, that are reduced in the absence of LT?
CXCR3 Binding (ligands) of in T cell
15) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2442868 Disease Relevance 0.70 Pain Relevance 0.04
Experimental evidence now suggests that CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8 and CXCR3 on hematogenous mononuclear cells recognize these chemoattractant and regulatory molecules to induce cell differentiation, adhesion or migration of distinct inflammatory cells in peripheral lymphoid organs, at the BBB and in the CNS during the course of EAE.
CXCR3 Binding (recognize) of in mononuclear cells associated with multiple sclerosis, inflammation, central nervous system and adhesions
16) Confidence 0.23 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.99 Pain Relevance 0.27
The binding of this protein to CXCR3 causes pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression (UCSC web browser).
CXCR3 Binding (binding) of in T-cell associated with adhesions
17) Confidence 0.14 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2227948 Disease Relevance 1.22 Pain Relevance 0.37
Specific inhibitors of CXCL10/CXCR3 interaction might therefore be useful for COPD treatment.
CXCR3 Binding (interaction) of associated with pulmonary disease
18) Confidence 0.13 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707155 Disease Relevance 1.09 Pain Relevance 0.35
These chemokines stimulate and attract CXCR3+ monocytes/macrophages, T cells, NK cells, mast cells and dendritic cells.
CXCR3 Binding (attract) of in T cells associated with chemokine
19) Confidence 0.12 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.67 Pain Relevance 0.60
These chemokines stimulate and attract CXCR3+ monocytes/macrophages, T cells, NK cells, mast cells and dendritic cells.
CXCR3 Binding (attract) of in mast cells associated with chemokine
20) Confidence 0.12 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.67 Pain Relevance 0.60

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