INT174423

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Context Info
Confidence 0.48
First Reported 2003
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 39
Total Number 62
Disease Relevance 29.45
Pain Relevance 6.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Smcp) cytoplasm (Smcp)
Anatomy Link Frequency
capsule 20
hepatocytes 2
skin 2
hair follicle 1
radial 1
Smcp (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 14 99.88 Very High Very High Very High
rheumatoid arthritis 408 99.84 Very High Very High Very High
neuropeptide release 112 99.68 Very High Very High Very High
Calcitonin gene-related peptide 56 99.54 Very High Very High Very High
fortral 96 98.94 Very High Very High Very High
agonist 38 98.64 Very High Very High Very High
Serotonin 14 98.44 Very High Very High Very High
Neuropeptide 112 98.40 Very High Very High Very High
Enkephalin 28 97.84 Very High Very High Very High
metalloproteinase 28 94.84 High High
Disease Link Frequency Relevance Heat
Melanoma 1512 100.00 Very High Very High Very High
Sprains And Strains 504 99.98 Very High Very High Very High
Rheumatoid Arthritis 436 99.84 Very High Very High Very High
Malignant Neoplastic Disease 96 99.84 Very High Very High Very High
Apoptosis 1180 99.38 Very High Very High Very High
Dysplastic Nevus Syndrome 24 98.56 Very High Very High Very High
Cancer 804 98.52 Very High Very High Very High
Toxicity 120 98.52 Very High Very High Very High
Infection 260 96.76 Very High Very High Very High
Infertility 20 96.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Potent inhibition of anchorage-independent growth by anti-MCSP:TRAIL
Gene_expression (growth) of anti-MCSP
1) Confidence 0.48 Published 2010 Journal Mol Cancer Section Body Doc Link PMC3000402 Disease Relevance 0.53 Pain Relevance 0
-R1 agonist (+)pentazocine did not abrogate synergy, suggesting that rimcazole synergizes with anti-MCSP:TRAIL activity via ?
Gene_expression (synergizes) of anti-MCSP associated with fortral and agonist
2) Confidence 0.48 Published 2010 Journal Mol Cancer Section Body Doc Link PMC3000402 Disease Relevance 0.59 Pain Relevance 0.19
Indeed, although anti-MCSP:TRAIL strongly bound to MCSP on normal human melanocytes (Additional file 1, Figure S1D), no apoptosis was induced in melanocytes even when treatment was performed with 4 ?
Gene_expression (although) of anti-MCSP in melanocytes associated with apoptosis
3) Confidence 0.48 Published 2010 Journal Mol Cancer Section Body Doc Link PMC3000402 Disease Relevance 0.94 Pain Relevance 0
Since ectopic expression of MCSP was also recently shown to induce anchorage-independent growth capacity, anti-MCSP:TRAIL was evaluated for its effect on anchorage-independent growth of melanoma cells.
Gene_expression (expression) of MCSP associated with melanoma
4) Confidence 0.43 Published 2010 Journal Mol Cancer Section Body Doc Link PMC3000402 Disease Relevance 0.47 Pain Relevance 0
Recent studies have revealed that MCSP expression may provide important tumorigenic signals to melanoma cells.
Gene_expression (expression) of MCSP associated with melanoma
5) Confidence 0.43 Published 2010 Journal Mol Cancer Section Body Doc Link PMC3000402 Disease Relevance 1.12 Pain Relevance 0.04
Once bound to MCSP-expressing melanoma cells, the anti-MCSP:TRAIL fusion protein can activate apoptotic TRAIL-signaling.
Gene_expression (expressing) of MCSP associated with melanoma and apoptosis
6) Confidence 0.43 Published 2010 Journal Mol Cancer Section Body Doc Link PMC3000402 Disease Relevance 1.55 Pain Relevance 0
Construction of fusion protein anti-MCSP:TRAIL
Gene_expression (Construction) of anti-MCSP
7) Confidence 0.42 Published 2010 Journal Mol Cancer Section Body Doc Link PMC3000402 Disease Relevance 0.05 Pain Relevance 0
Indeed, treatment of MCSP-transfected M14 melanoma cells (M14.MCSP) with anti-MCSP:TRAIL resulted in dose-dependent activation of apoptosis within 16 h, whereas parental MCSP-negative M14 cells were resistant to treatment with anti-MCSP:TRAIL (Figure 1A).
Neg (negative) Gene_expression (resistant) of MCSP associated with melanoma and apoptosis
8) Confidence 0.42 Published 2010 Journal Mol Cancer Section Body Doc Link PMC3000402 Disease Relevance 1.33 Pain Relevance 0.04
Similarly, normal human MCSP-negative hepatocytes were fully resistant to treatment with anti-MCSP:TRAIL (Figure 4C).
Gene_expression (resistant) of MCSP in hepatocytes
9) Confidence 0.42 Published 2010 Journal Mol Cancer Section Body Doc Link PMC3000402 Disease Relevance 0.76 Pain Relevance 0
Similarly, normal human MCSP-negative hepatocytes were fully resistant to treatment with anti-MCSP:TRAIL (Figure 4C).
Gene_expression (resistant) of anti-MCSP in hepatocytes
10) Confidence 0.42 Published 2010 Journal Mol Cancer Section Body Doc Link PMC3000402 Disease Relevance 0.70 Pain Relevance 0
Indeed, treatment of MCSP-transfected M14 melanoma cells (M14.MCSP) with anti-MCSP:TRAIL resulted in dose-dependent activation of apoptosis within 16 h, whereas parental MCSP-negative M14 cells were resistant to treatment with anti-MCSP:TRAIL (Figure 1A).
Neg (negative) Gene_expression (resistant) of anti-MCSP associated with melanoma and apoptosis
11) Confidence 0.42 Published 2010 Journal Mol Cancer Section Body Doc Link PMC3000402 Disease Relevance 1.32 Pain Relevance 0.03
Culture medium containing anti-MCSP:TRAIL was cleared by centrifugation (10 000 g, 10 min), filter sterilized, and stored at -80°C until further use.
Gene_expression (containing) of anti-MCSP
12) Confidence 0.42 Published 2010 Journal Mol Cancer Section Body Doc Link PMC3000402 Disease Relevance 0.22 Pain Relevance 0
Mice received daily i.v. saline injections or anti-MCSP:TRAIL injections (0.14 mg/kg).
Gene_expression (injections) of anti-MCSP
13) Confidence 0.42 Published 2010 Journal Mol Cancer Section Body Doc Link PMC3000402 Disease Relevance 0.61 Pain Relevance 0.03
Fusion protein anti-MCSP:TRAIL was produced in CHO-K1 cells using previously described methods [14,16].
Gene_expression (produced) of anti-MCSP
14) Confidence 0.42 Published 2010 Journal Mol Cancer Section Body Doc Link PMC3000402 Disease Relevance 0.05 Pain Relevance 0
Importantly, over-expression of MCSP correlates with an unfavorable prognosis [4].
Gene_expression (expression) of MCSP
15) Confidence 0.37 Published 2010 Journal Mol Cancer Section Body Doc Link PMC3000402 Disease Relevance 1.17 Pain Relevance 0.03
Furthermore, non-metastatic radial growth tumor cells acquired anchorage-independent growth characteristics upon ectopic expression of MCSP [6].
Gene_expression (expression) of MCSP in radial associated with cancer
16) Confidence 0.37 Published 2010 Journal Mol Cancer Section Body Doc Link PMC3000402 Disease Relevance 1.05 Pain Relevance 0.07
MCSP is highly expressed on the cell surface of both benign dysplastic nevi and on over 85% of malignant melanomas [3].
Gene_expression (expressed) of MCSP associated with melanoma and dysplastic nevus syndrome
17) Confidence 0.37 Published 2010 Journal Mol Cancer Section Body Doc Link PMC3000402 Disease Relevance 1.15 Pain Relevance 0
Indeed, treatment of MCSP-transfected M14 melanoma cells (M14.MCSP) with anti-MCSP:TRAIL resulted in dose-dependent activation of apoptosis within 16 h, whereas parental MCSP-negative M14 cells were resistant to treatment with anti-MCSP:TRAIL (Figure 1A).
Gene_expression (transfected) of MCSP associated with melanoma and apoptosis
18) Confidence 0.37 Published 2010 Journal Mol Cancer Section Body Doc Link PMC3000402 Disease Relevance 1.27 Pain Relevance 0.04
Thus, anti-MCSP:TRAIL activity is strictly dependent on binding to cell surface-expressed MCSP on malignant cells.
Gene_expression (expressed) of MCSP associated with malignant neoplastic disease
19) Confidence 0.37 Published 2010 Journal Mol Cancer Section Body Doc Link PMC3000402 Disease Relevance 1.14 Pain Relevance 0
Expression of MCSP on normal tissue is mainly restricted to cells of the melanocyte lineage, but has also been detected in basal cells of the epidermis and within the hair follicle, in pericytes, chondrocytes and smooth muscle cells [3].
Gene_expression (Expression) of MCSP in hair follicle
20) Confidence 0.37 Published 2010 Journal Mol Cancer Section Body Doc Link PMC3000402 Disease Relevance 1.21 Pain Relevance 0.03

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