INT174424

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Context Info
Confidence 0.25
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 2.68
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Smcp) cytoplasm (Smcp)
Anatomy Link Frequency
capsule 4
Smcp (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 102 99.84 Very High Very High Very High
agonist 6 91.76 High High
neuropeptide release 24 88.88 High High
Inflammation 39 88.04 High High
Arthritis 7 84.04 Quite High
Neuropeptide 24 79.24 Quite High
Glutamate 7 73.60 Quite High
chemokine 29 73.24 Quite High
substance P 3 64.00 Quite High
Calcitonin gene-related peptide 12 63.32 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 108 99.84 Very High Very High Very High
Pressure And Volume Under Development 9 97.24 Very High Very High Very High
Merkel Cell Carcinoma 9 94.56 High High
Apoptosis 150 93.60 High High
Sprains And Strains 101 91.44 High High
INFLAMMATION 39 88.04 High High
Hyperplasia 21 84.24 Quite High
Arthritis 8 84.04 Quite High
Bacillus Anthracis Infection 4 75.56 Quite High
Skin Diseases 9 71.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intriguingly, cross-linking of MCSP by bead-coated mAb 9.2.27 has also been used to achieve activation of MCSP-signaling [6].
MCSP Binding (linking) of
1) Confidence 0.25 Published 2010 Journal Mol Cancer Section Body Doc Link PMC3000402 Disease Relevance 0 Pain Relevance 0
Intriguingly, cross-linking of MCSP by bead-coated mAb 9.2.27 has also been used to achieve activation of MCSP-signaling [6].
MCSP Binding (cross) of
2) Confidence 0.25 Published 2010 Journal Mol Cancer Section Body Doc Link PMC3000402 Disease Relevance 0 Pain Relevance 0
Likewise, A375M.FADD-DED cells were also fully resistant to treatment with anti-MCSP:TRAIL (Figure 1E).
anti-MCSP Binding (treatment) of
3) Confidence 0.23 Published 2010 Journal Mol Cancer Section Body Doc Link PMC3000402 Disease Relevance 0.51 Pain Relevance 0
When cultured in serum-supplemented medium, alignment of MCs was observed (Figure 4a, b).
MCs Binding (alignment) of
4) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722079 Disease Relevance 0.25 Pain Relevance 0
Thus, MCs react to histamine and are able to perceive tissue acidification and cell swelling through TRPV4.
MCs Binding (react) of associated with pressure and volume under development
5) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722079 Disease Relevance 0.10 Pain Relevance 0.29
We demonstrated here that MCs react to histamine and to TRPV4 stimulation by releasing VIP (Figure 7).
MCs Binding (react) of
6) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722079 Disease Relevance 0.40 Pain Relevance 0
The present study suggests that Th1-associated CXCR3 expression in synovial tissue is associated with distinct biologic functions of MCs in RA.
MCs Binding (associated) of associated with rheumatoid arthritis
7) Confidence 0.12 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.08 Pain Relevance 0.58
Using a crude “capsular” extract from F. tularensis subsp. tularensis SCHU S4 as prepared by the method of Hood as an immunogen [16], we developed a bank of monoclonal antibodies and evaluated each for binding to antigens with the characteristics of a typical polysaccharide capsule that help distinguish it from the LPS.
capsule Binding (binding) of in capsule
8) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2897883 Disease Relevance 0.05 Pain Relevance 0
Monoclonal antibody FB11, which reacts with the O-antigen, also binds to the capsule.
capsule Binding (binds) of in capsule
9) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2897883 Disease Relevance 0.17 Pain Relevance 0.04
Two of these monoclonal antibodies bound a high mass capsule-like structure on Western blot that matched these characteristics.
capsule Binding (bound) of in capsule
10) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2897883 Disease Relevance 0 Pain Relevance 0
This antibody appears to react only with the capsule suggesting that this is the immunodominant epitope on that structure.
capsule Binding (react) of in capsule
11) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2897883 Disease Relevance 0.13 Pain Relevance 0.03

General Comments

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