INT174426

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Context Info
Confidence 0.49
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 11.68
Pain Relevance 3.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ccr8) plasma membrane (Ccr8) signal transducer activity (Ccr8)
Anatomy Link Frequency
macrophages 2
leukocytes 2
lymphocytes 2
microglia 2
T cells 1
Ccr8 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 741 100.00 Very High Very High Very High
Multiple sclerosis 540 99.96 Very High Very High Very High
cytokine 89 99.56 Very High Very High Very High
Inflammation 455 98.48 Very High Very High Very High
Spinal cord 72 94.48 High High
Central nervous system 450 93.92 High High
agonist 4 87.96 High High
rheumatoid arthritis 102 83.76 Quite High
Neuritis 54 57.84 Quite High
Arthritis 7 46.32 Quite Low
Disease Link Frequency Relevance Heat
Demyelinating Disease 702 99.96 Very High Very High Very High
Progressive Multifocal Leukoencephalopathy 9 99.88 Very High Very High Very High
Stroke 9 98.94 Very High Very High Very High
INFLAMMATION 455 98.48 Very High Very High Very High
Cancer 201 97.40 Very High Very High Very High
Necrosis 39 97.24 Very High Very High Very High
Multiple Sclerosis 711 95.08 Very High Very High Very High
Central Nervous System Disease 432 93.92 High High
Recurrence 144 93.28 High High
Sprains And Strains 73 89.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CCR8, the receptor for CCL1, has been detected in vitro on TH2 and regulatory lymphocytes, macrophages and microglia.
Gene_expression (detected) of CCR8 in microglia
1) Confidence 0.49 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.12 Pain Relevance 0.25
While the expression kinetics of CCR1 and CCR5 may discriminate between histological type II and type III lesions of MS, CCR8 is similarly expressed in both lesions types (Table 1).
Gene_expression (expressed) of CCR8 associated with multiple sclerosis
2) Confidence 0.49 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.82 Pain Relevance 0.29
As both CCL1 and CCR8 were detected in microglia, an autocrine signaling mechanism was postulated.
Gene_expression (detected) of CCR8 in microglia
3) Confidence 0.49 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.21 Pain Relevance 0.25
Expression of the corresponding CCR1, CCR2, CCR3, CCR5 and CCR8 receptors has been demonstrated on infiltrating leukocytes, but also on microglia, dendritic cells and astrocytes.
Gene_expression (Expression) of CCR8 in leukocytes
4) Confidence 0.49 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.29 Pain Relevance 0.48
Phagocytic macrophages and activated microglia in stroke and progressive multifocal leukoencephalopathy also expressed CCR8.
Gene_expression (expressed) of CCR8 in macrophages associated with progressive multifocal leukoencephalopathy and stroke
5) Confidence 0.49 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.09 Pain Relevance 0.26
CCR8 expression correlated with the demyelinating activity, but was not restricted to the MS pathology.
Gene_expression (expression) of CCR8 associated with multiple sclerosis and demyelinating disease
6) Confidence 0.49 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.16 Pain Relevance 0.26
Moreover, targeting TLR2 inhibits the expression of chemokines CCL22, MCP-1 and CCR8 to attenuate the recruitment of suppressive immune cells to the tumor microenvironment [26], [35] and result in an overall reduction of suppressive cytokines in the tumor tissue.
Gene_expression (expression) of CCR8 in immune cells associated with chemokine, cancer and cytokine
7) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 1.38 Pain Relevance 0.10
In contrast, Th2 lymphocytes were reported to produce CCR3, CCR4, and CCR8 [5,12,13,18,25].
Gene_expression (produce) of CCR8 in lymphocytes
8) Confidence 0.38 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 0.45 Pain Relevance 0.50
TLR2 activity mediated HSP60-stimulated release of the suppressive cytokines, chemokines, and the expression of CCR8 in B16 cells (Fig.
Gene_expression (expression) of CCR8 associated with chemokine and cytokine
9) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.15 Pain Relevance 0.24
Normal resting CD4+ T cells and primed non-activated T cells expressed mRNA for CCR1, CCR2, CCR3, CCR5, CCR6, CCR7 and CCR8.
Gene_expression (expressed) of CCR8 in T cells
10) Confidence 0.17 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.77 Pain Relevance 0.52
CCR8, the receptor for CCL1, has been detected in vitro on TH2 and regulatory lymphocytes, macrophages and microglia.
Gene_expression (detected) of CCR8 in macrophages
11) Confidence 0.17 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.12 Pain Relevance 0.25
CCR8, the receptor for CCL1, has been detected in vitro on TH2 and regulatory lymphocytes, macrophages and microglia.
Gene_expression (detected) of CCR8 in lymphocytes
12) Confidence 0.17 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.12 Pain Relevance 0.25

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