INT174427

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Context Info
Confidence 0.66
First Reported 2003
Last Reported 2011
Negated 0
Speculated 2
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 10.70
Pain Relevance 4.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cxcr3) plasma membrane (Cxcr3) signal transducer activity (Cxcr3)
Anatomy Link Frequency
T cells 6
macrophage 2
endothelial cells 2
fibroblasts 2
mast cells 2
Cxcr3 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 612 100.00 Very High Very High Very High
Osteoarthritis 300 100.00 Very High Very High Very High
Inflammation 192 99.98 Very High Very High Very High
chemokine 192 99.68 Very High Very High Very High
Multiple sclerosis 2 79.80 Quite High
Crohn's disease 25 64.40 Quite High
Central nervous system 2 50.40 Quite High
cytokine 74 41.24 Quite Low
metalloproteinase 6 7.60 Low Low
Arthritis 42 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 612 100.00 Very High Very High Very High
Osteoarthritis 300 100.00 Very High Very High Very High
INFLAMMATION 210 99.98 Very High Very High Very High
Colitis 69 99.76 Very High Very High Very High
Adhesions 26 99.68 Very High Very High Very High
Mycobacterial Infection 152 97.92 Very High Very High Very High
Infection 113 90.96 High High
Disease 121 88.88 High High
Demyelinating Disease 2 79.80 Quite High
Multiple Sclerosis 2 78.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To confirm the increase in CXCR3 expression at the protein level, Western blot experiments in selected extracts from synovial tissue of RA and OA patients were conducted (Fig. 3a).
Positive_regulation (increase) of Gene_expression (expression) of CXCR3 associated with rheumatoid arthritis and osteoarthritis
1) Confidence 0.66 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.43 Pain Relevance 0.66
The ligands of CXCR3 (CXCL9 and CXCL10) do not chemotactically attract granulocytes, but appear to promote T-cell adhesion to endothelial cells [44].
Positive_regulation (promote) of Gene_expression (ligands) of CXCR3 in endothelial cells associated with adhesions
2) Confidence 0.48 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 0.84 Pain Relevance 0.41
In order to consider the degree of differential infiltration of T lymphocytes as well as their influence on inflammation-induced CXCR3 expression between RA and OA, we analyzed the expression of TCR-?
Positive_regulation (induced) of Spec (analyzed) Gene_expression (expression) of CXCR3 in T lymphocytes associated with inflammation, rheumatoid arthritis and osteoarthritis
3) Confidence 0.44 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.46 Pain Relevance 0.76
Additional expression of CXCR3 protein on synovial fibroblasts in both RA and OA points possibly to an increased level of activation among these cells.
Positive_regulation (increased) of Gene_expression (expression) of CXCR3 protein in fibroblasts associated with rheumatoid arthritis and osteoarthritis
4) Confidence 0.44 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.26 Pain Relevance 0.68
Because activated CD3+ T cells have been found to be the major cell type expressing chemokine receptors, the increase in CXCR3 expression could be due, at least in part, to higher levels of T cells in RA than in OA synovial tissue samples [4,22].
Positive_regulation (increase) of Gene_expression (expression) of CXCR3 in T cells associated with chemokine, rheumatoid arthritis and osteoarthritis
5) Confidence 0.44 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.73 Pain Relevance 0.99
High CXCR3 expression in synovial mast cells associated with CXCL9 and CXCL10 expression in inflammatory synovial tissues of patients with rheumatoid arthritis

To improve our knowledge on the pathophysiology of rheumatoid arthritis (RA), we investigated gene expression patterns in synovial tissue from RA and osteoarthritis (OA) patients.

Spec (investigated) Positive_regulation (High) of Spec (investigated) Gene_expression (expression) of CXCR3 in mast cells associated with inflammation, rheumatoid arthritis and osteoarthritis
6) Confidence 0.44 Published 2003 Journal Arthritis Res Ther Section Title Doc Link PMC193722 Disease Relevance 1.17 Pain Relevance 0.56
TEPM expressed elevated levels of mRNA for Cxcr4, Ccr1, Ccrl2, whilst BMM expressed higher levels of Ccr2, Cx3cr1 and Cxcr3.
Positive_regulation (elevated) of Gene_expression (expressed) of Cxcr3
7) Confidence 0.40 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.32 Pain Relevance 0.19
TEPM expressed elevated levels of mRNA for Cxcr4, Ccr1, Ccrl2, whilst BMM expressed higher levels of Ccr2, Cx3cr1 and Cxcr3.
Positive_regulation (levels) of Gene_expression (expressed) of Cxcr3
8) Confidence 0.40 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.31 Pain Relevance 0.16
The expression of CXCR3 and its ligands (CXCL10 >> CXCL11 or CXCL9) by mucosal T cells significantly increased in mice challenged with live Mycobacteria than compared with similar mice challenged with heat-killed Mycobacteria or controls.
Positive_regulation (increased) of Gene_expression (expression) of CXCR3 in T cells
9) Confidence 0.38 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 1.15 Pain Relevance 0.14
This would shed further light on the detrimental (increased expression of CXCR3-ligating chemokines, Th1 recruitment and associated pathology) versus beneficial (optimal Th1 responses required for macrophage activation and mycobacterial control) effects of early neutrophil influx in TB pathogenesis.
Positive_regulation (increased) of Gene_expression (expression) of CXCR3 in macrophage associated with mycobacterial infection and chemokine
10) Confidence 0.19 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 1.04 Pain Relevance 0.11

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