INT174429

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Context Info
Confidence 0.73
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.82
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cd68) plasma membrane (Cd68) lysosome (Cd68)
Anatomy Link Frequency
neurons 1
lamina 1
fibroblast 1
Cd68 (Mus musculus)
Pain Link Frequency Relevance Heat
Substantia nigra 37 99.20 Very High Very High Very High
Inflammation 57 57.92 Quite High
dopaminergic neurodegeneration 5 50.00 Quite Low
Osteoarthritis 50 48.28 Quite Low
rheumatoid arthritis 102 48.00 Quite Low
Dopamine 6 43.56 Quite Low
palliative 2 39.52 Quite Low
Crohn's disease 36 19.84 Low Low
Cauda equina syndrome 1 9.36 Low Low
Sciatica 3 5.40 Low Low
Disease Link Frequency Relevance Heat
Metastasis 51 80.08 Quite High
Cancer 51 79.96 Quite High
Colon Cancer 42 60.48 Quite High
INFLAMMATION 57 57.92 Quite High
Inflammatory Bowel Disease 78 54.76 Quite High
Abscess 1 52.56 Quite High
Necrosis 10 50.00 Quite Low
Osteoarthritis 50 48.28 Quite Low
Rheumatoid Arthritis 102 48.00 Quite Low
Adhesions 6 37.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phycoerythrin (PE)-conjugated mAbs (mouse IgG1) directed against CD4, CD8, CD19, CD 14, CD55, CD68, and Cy-conjugated mAbs (mouse IgG1) against CD25 were used.
Localization (directed) of CD68
1) Confidence 0.73 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628152 Disease Relevance 0 Pain Relevance 0
Relationship between CD68TFHotspot and clinicopathologic characteristics
Localization (Relationship) of CD68TFHotspot
2) Confidence 0.71 Published 2010 Journal J Transl Med Section Body Doc Link PMC2841127 Disease Relevance 0.66 Pain Relevance 0
All sections were blocked in PBS, 5% goat serum albumin (blocking buffer) for 20 min, and staining was performed with the following primary antibodies at the given dilution in blocking buffer (1 hour, room temperature): mouse monoclonal antibodies against CXCR1 (Clone 42705.111, 1:40; R&D Systems, Minneapolis, MN, USA), CXCR2 (Clone 48311.211, 1:10; R&D), CXCR3 (Clone 49801.111, 1:100; R&D), MC tryptase (Clone AA1, 1:50; Dako, Hamburg, Germany), CD68 (Clone KP1, 1:80; Dako), fibroblast prolyl-4-hydroxylase (Clone 5B5, 1:10; Dako), and CD3 (Clone F7.2.38, 1:50; Dako).
Localization (1:80) of CD68 in fibroblast
3) Confidence 0.36 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 0 Pain Relevance 0
-SYN-expressing neurons in SN, which was further confirmed by the co-localization of CD68 and NF-?
Localization (localization) of CD68 in neurons associated with substantia nigra
4) Confidence 0.35 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2975641 Disease Relevance 0 Pain Relevance 0.19
To calculate the percentage of CD68, IgA and CD3, one thousand lamina propria cells per biopsy were counted.
Localization (percentage) of CD68 in lamina
5) Confidence 0.29 Published 2007 Journal BMC Gastroenterol Section Body Doc Link PMC1995200 Disease Relevance 0.17 Pain Relevance 0.03

General Comments

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