INT174429

Context Info Confidence 0.73 First Reported 2003 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 0.82 Pain Relevance 0.22

endosome (Cd68) plasma membrane (Cd68) lysosome (Cd68)

Anatomy Link Frequency neurons 1 lamina 1 fibroblast 1 Cd68 (Mus musculus)

Pain Link Frequency Relevance Heat Substantia nigra 37 99.20 Inflammation 57 57.92 dopaminergic neurodegeneration 5 50.00 Osteoarthritis 50 48.28 rheumatoid arthritis 102 48.00 Dopamine 6 43.56 palliative 2 39.52 Crohn's disease 36 19.84 Cauda equina syndrome 1 9.36 Sciatica 3 5.40

Disease Link Frequency Relevance Heat Metastasis 51 80.08 Cancer 51 79.96 Colon Cancer 42 60.48 INFLAMMATION 57 57.92 Inflammatory Bowel Disease 78 54.76 Abscess 1 52.56 Necrosis 10 50.00 Osteoarthritis 50 48.28 Rheumatoid Arthritis 102 48.00 Adhesions 6 37.48

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Phycoerythrin (PE)-conjugated mAbs (mouse IgG1) directed against CD4, CD8, CD19, CD 14, CD55, CD68, and Cy-conjugated mAbs (mouse IgG1) against CD25 were used.

Localization (directed) of CD68

1) Confidence 0.73 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628152 Disease Relevance 0 Pain Relevance 0

Relationship between CD68TFHotspot and clinicopathologic characteristics

Localization (Relationship) of CD68TFHotspot

2) Confidence 0.71 Published 2010 Journal J Transl Med Section Body Doc Link PMC2841127 Disease Relevance 0.66 Pain Relevance 0

All sections were blocked in PBS, 5% goat serum albumin (blocking buffer) for 20 min, and staining was performed with the following primary antibodies at the given dilution in blocking buffer (1 hour, room temperature): mouse monoclonal antibodies against CXCR1 (Clone 42705.111, 1:40; R&D Systems, Minneapolis, MN, USA), CXCR2 (Clone 48311.211, 1:10; R&D), CXCR3 (Clone 49801.111, 1:100; R&D), MC tryptase (Clone AA1, 1:50; Dako, Hamburg, Germany), CD68 (Clone KP1, 1:80; Dako), fibroblast prolyl-4-hydroxylase (Clone 5B5, 1:10; Dako), and CD3 (Clone F7.2.38, 1:50; Dako).

Localization (1:80) of CD68 in fibroblast

3) Confidence 0.36 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 0 Pain Relevance 0

-SYN-expressing neurons in SN, which was further confirmed by the co-localization of CD68 and NF-?

Localization (localization) of CD68 in neurons associated with substantia nigra

4) Confidence 0.35 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2975641 Disease Relevance 0 Pain Relevance 0.19

To calculate the percentage of CD68, IgA and CD3, one thousand lamina propria cells per biopsy were counted.

Localization (percentage) of CD68 in lamina

5) Confidence 0.29 Published 2007 Journal BMC Gastroenterol Section Body Doc Link PMC1995200 Disease Relevance 0.17 Pain Relevance 0.03

General Comments

This test has worked.