INT174432

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Context Info
Confidence 0.68
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 13
Disease Relevance 15.73
Pain Relevance 7.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cxcr3) plasma membrane (Cxcr3) signal transducer activity (Cxcr3)
Anatomy Link Frequency
lymph node 3
T cell 2
lymphocytes 1
mast cell 1
Cxcr3 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 612 99.68 Very High Very High Very High
Inflammation 335 98.88 Very High Very High Very High
Osteoarthritis 300 98.56 Very High Very High Very High
Central nervous system 50 98.36 Very High Very High Very High
cytokine 139 98.32 Very High Very High Very High
Multiple sclerosis 66 98.16 Very High Very High Very High
chemokine 324 97.76 Very High Very High Very High
interstitial cystitis 246 92.04 High High
Lasting pain 6 65.36 Quite High
antagonist 8 60.12 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 612 99.68 Very High Very High Very High
Cystitis 420 99.10 Very High Very High Very High
INFLAMMATION 335 98.88 Very High Very High Very High
Osteoarthritis 300 98.56 Very High Very High Very High
Central Nervous System Disease 48 98.36 Very High Very High Very High
Demyelinating Disease 84 98.16 Very High Very High Very High
Disease 193 97.88 Very High Very High Very High
Neurological Disease 12 97.12 Very High Very High Very High
Meningitis 3 96.00 Very High Very High Very High
Encephalitis 2 95.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although CXCR3 expression was previously demonstrated in synovial tissue of RA patients, high CXCR3 mRNA levels in synovial MCs has not yet been described [5,17].
Transcription (levels) of CXCR3 associated with rheumatoid arthritis
1) Confidence 0.68 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.83 Pain Relevance 1.02
mRNA ratios and is apparently associated with high CXCR3 mRNA levels on MCs within RA synovial tissue.
Transcription (levels) of CXCR3 associated with rheumatoid arthritis
2) Confidence 0.68 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.74 Pain Relevance 0.91
Increased CXCR3 mRNA expression within synovial tissue from RA versus OA patients is reflected by higher CXCR3/TCR-?
Transcription (expression) of CXCR3 associated with rheumatoid arthritis and osteoarthritis
3) Confidence 0.68 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.82 Pain Relevance 0.98
We demonstrate that CXCR3 as well as CXCL9, CXCL10 and CXCL11 mRNA were significantly expressed by urinary bladder lymphocytes, while CXCR3 and CXCL9 transcripts were significantly expressed by iliac lymph node leukocytes following CYP treatment.
Transcription (expressed) of CXCR3 in lymph node
4) Confidence 0.52 Published 2008 Journal J Immune Based Ther Vaccines Section Abstract Doc Link PMC2583981 Disease Relevance 0.56 Pain Relevance 0.35
CYP-induced cystitis in mice led to substantial increases in the expression of CXCL10, CXCL11, and CXCR3 mRNA by urinary bladder leukocytes as well as modest increases in the expression of CXCL9 and CXCR3 transcripts by iliac lymph node lymphocytes than compared to normal, untreated mice (Figure 3A).
Transcription (expression) of CXCR3 in lymph node associated with cystitis
5) Confidence 0.52 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.62 Pain Relevance 0.08
CYP-induced cystitis in mice led to substantial increases in the expression of CXCL10, CXCL11, and CXCR3 mRNA by urinary bladder leukocytes as well as modest increases in the expression of CXCL9 and CXCR3 transcripts by iliac lymph node lymphocytes than compared to normal, untreated mice (Figure 3A).
Transcription (expression) of CXCR3 mRNA in lymph node associated with cystitis
6) Confidence 0.52 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.70 Pain Relevance 0.10
We demonstrate that CXCR3 as well as CXCL9, CXCL10 and CXCL11 mRNA were significantly expressed by urinary bladder lymphocytes, while CXCR3 and CXCL9 transcripts were significantly expressed by iliac lymph node leukocytes following CYP treatment.
Transcription (expressed) of CXCR3 in lymphocytes
7) Confidence 0.52 Published 2008 Journal J Immune Based Ther Vaccines Section Abstract Doc Link PMC2583981 Disease Relevance 0.54 Pain Relevance 0.34
Urinary bladder histology as well as mucosal (iliac lymph node and urinary bladder) and peripheral (spleen) leukocyte expression of CXCR3, CXCL9, CXCL10, and CXCL11 mRNA transcripts as well as CD4+ T cell, mast cell, and NK/NKT cell numbers were compared among naïve and CYP-treated mice given control or anti-CXCL10 Abs.
Transcription (transcripts) of CXCR3 in T cell
8) Confidence 0.52 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.19 Pain Relevance 0.40
RT-PCR revealed increased CXCR3 mRNA levels (P < 0.001) in RA as compared with OA synovial tissue (Fig. 2a).
Transcription (levels) of CXCR3 associated with rheumatoid arthritis and osteoarthritis
9) Confidence 0.51 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.37 Pain Relevance 0.82
Elevated protein levels in RA synovial tissue were detected for CXCR1 and CXCR3 by Western blotting.
Transcription (detected) of CXCR3 associated with rheumatoid arthritis
10) Confidence 0.51 Published 2003 Journal Arthritis Res Ther Section Abstract Doc Link PMC193722 Disease Relevance 1.52 Pain Relevance 0.69
This an increase of 3.6-fold in CXCR3 transcript levels was found in synovial tissue of RA patients (Fig. 2a,2b).
Transcription (levels) of CXCR3 associated with rheumatoid arthritis
11) Confidence 0.51 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.32 Pain Relevance 0.79
Giunti et al [58] detected CCR5, CCR7 and CXCR3 positive T cells in the CSF of patients with MS and other inflammatory neurological disease (IND) (meningitis, encephalitis, CIDP, neuroborreliosis).
Transcription (detected) of CXCR3 in T cells associated with multiple sclerosis, chronic inflammatory demyelinating polyradiculoneuropathy, meningitis, neurological disease, inflammation and encephalitis
12) Confidence 0.42 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.33 Pain Relevance 0.43
Urinary bladder histology as well as mucosal (iliac lymph node and urinary bladder) and peripheral (spleen) leukocyte expression of CXCR3, CXCL9, CXCL10, and CXCL11 mRNA transcripts as well as CD4+ T cell, mast cell, and NK/NKT cell numbers were compared among naïve and CYP-treated mice given control or anti-CXCL10 Abs.
Transcription (transcripts) of CXCR3 in mast cell
13) Confidence 0.18 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.19 Pain Relevance 0.40

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