INT174434

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Context Info
Confidence 0.53
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.45
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Smcp) cytoplasm (Smcp)
Anatomy Link Frequency
skin 1
Smcp (Mus musculus)
Pain Link Frequency Relevance Heat
neuropeptide release 32 100.00 Very High Very High Very High
Neuropeptide 32 96.12 Very High Very High Very High
rheumatoid arthritis 102 96.00 Very High Very High Very High
substance P 4 94.00 High High
Calcitonin gene-related peptide 16 93.32 High High
Glutamate 4 92.16 High High
Enkephalin 8 91.60 High High
Neurotransmitter 20 91.28 High High
Mechanotransduction 20 85.68 High High
cytokine 15 83.72 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 56 96.44 Very High Very High Very High
Rheumatoid Arthritis 110 96.00 Very High Very High Very High
Merkel Cell Carcinoma 12 94.56 High High
Melanoma 63 93.68 High High
Pressure And Volume Under Development 12 92.16 High High
Cancer 36 90.84 High High
Hyperplasia 27 84.24 Quite High
Skin Diseases 12 75.60 Quite High
Disease 26 68.16 Quite High
INFLAMMATION 41 66.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The resultant fusion protein, anti-MCSP:TRAIL, was equipped to selectively accrete at the cell surface of MCSP-positive cells only and subsequently trigger TRAIL-mediated apoptosis.
Localization (accrete) of anti-MCSP associated with apoptosis
1) Confidence 0.53 Published 2010 Journal Mol Cancer Section Body Doc Link PMC3000402 Disease Relevance 1.51 Pain Relevance 0.04
This pathway remains to be clarified for neuropeptide release from MCs.
Localization (release) of MCs associated with neuropeptide release
2) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722079 Disease Relevance 0 Pain Relevance 0.42
We demonstrated here that MCs react to histamine and to TRPV4 stimulation by releasing VIP (Figure 7).
Localization (releasing) of MCs
3) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722079 Disease Relevance 0.41 Pain Relevance 0
Through the release of VIP following histamine stimulation and activation of TRPV4, MCs probably act in skin pathophysiology, but their exact role remains to be defined.
Localization (release) of MCs in skin
4) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722079 Disease Relevance 0 Pain Relevance 0.43
Ca2+ signaling in neuropeptide release from MCs
Localization (release) of MCs associated with neuropeptide release
5) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722079 Disease Relevance 0 Pain Relevance 0.31
Unexpectedly, in all samples inspected prominent staining for CXCR3 was found on scattered MCs within sublining layers and interstitial areas, as well as in perivascular compartments of the rheumatoid synovial tissue (Fig. 4).
Localization (found) of MCs
6) Confidence 0.25 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 0.53 Pain Relevance 0.27

General Comments

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