INT174435

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Context Info
Confidence 0.53
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.16
Pain Relevance 1.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cxcr2) plasma membrane (Cxcr2) intracellular (Cxcr2)
signal transducer activity (Cxcr2)
Anatomy Link Frequency
skin 1
Cxcr2 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 204 98.60 Very High Very High Very High
Osteoarthritis 100 96.00 Very High Very High Very High
Arthritis 14 93.52 High High
psoriasis 2 90.96 High High
chemokine 58 89.44 High High
Inflammation 48 60.88 Quite High
cytokine 16 51.28 Quite High
fibrosis 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Psoriasis 4 98.64 Very High Very High Very High
Rheumatoid Arthritis 204 98.60 Very High Very High Very High
Osteoarthritis 100 96.00 Very High Very High Very High
Hyperplasia 6 93.84 High High
Arthritis 16 93.52 High High
Disease 26 85.44 High High
INFLAMMATION 48 60.88 Quite High
Adhesions 8 5.00 Very Low Very Low Very Low
Necrosis 6 5.00 Very Low Very Low Very Low
Cancer 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another group demonstrated that mRNA levels of the CXCL8 receptors CXCR1 and CXCR2 were 10-fold elevated in injured psoriatic epidermis as compared with normal skin, suggesting a role for high expression of CXCL8 receptors in epidermal hyperplasia, leukocyte infiltration, and increased HLA-DR expression in psoriasis [7,32].
Transcription (levels) of CXCR2 in skin associated with psoriasis and hyperplasia
1) Confidence 0.53 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 0.78 Pain Relevance 0.39
Similarly, levels of CXCR1 and CXCR2 transcripts were increased by 10-fold (P < 0.05) and approximately sixfold (P < 0.05) in RA versus OA synovial samples (Fig. 2b), respectively.
Transcription (levels) of CXCR2 associated with rheumatoid arthritis and osteoarthritis
2) Confidence 0.41 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.38 Pain Relevance 0.80

General Comments

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