INT174437

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Context Info
Confidence 0.71
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.36
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cxcr3) plasma membrane (Cxcr3) signal transducer activity (Cxcr3)
Anatomy Link Frequency
fibroblast 1
lung 1
Cxcr3 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 133 100.00 Very High Very High Very High
Inflammation 77 98.64 Very High Very High Very High
cytokine 28 92.56 High High
rheumatoid arthritis 108 66.64 Quite High
psoriasis 4 64.88 Quite High
antagonist 19 64.40 Quite High
Osteoarthritis 50 51.96 Quite High
Inflammatory response 3 26.48 Quite Low
corticosteroid 13 5.00 Very Low Very Low Very Low
Arthritis 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 7 99.92 Very High Very High Very High
Toxemia 10 99.28 Very High Very High Very High
Pneumonia 5 98.84 Very High Very High Very High
Disease Progression 10 96.92 Very High Very High Very High
Pulmonary Disease 107 95.96 Very High Very High Very High
Bacillus Anthracis Infection 26 95.92 Very High Very High Very High
Infection 63 94.24 High High
INFLAMMATION 79 93.60 High High
Sprains And Strains 37 86.24 High High
Immune System Diseases 1 79.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All sections were blocked in PBS, 5% goat serum albumin (blocking buffer) for 20 min, and staining was performed with the following primary antibodies at the given dilution in blocking buffer (1 hour, room temperature): mouse monoclonal antibodies against CXCR1 (Clone 42705.111, 1:40; R&D Systems, Minneapolis, MN, USA), CXCR2 (Clone 48311.211, 1:10; R&D), CXCR3 (Clone 49801.111, 1:100; R&D), MC tryptase (Clone AA1, 1:50; Dako, Hamburg, Germany), CD68 (Clone KP1, 1:80; Dako), fibroblast prolyl-4-hydroxylase (Clone 5B5, 1:10; Dako), and CD3 (Clone F7.2.38, 1:50; Dako).
Localization (1:80) of CXCR3 in fibroblast
1) Confidence 0.71 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 0.10 Pain Relevance 0.05
Neutralization of the shared chemokine receptor CXCR3, responsible for mediating cellular recruitment in response to CXCL9, CXCL10, and CXCL11, was not found to increase host susceptibility to inhalational anthrax.
Localization (Neutralization) of CXCR3 associated with chemokine and bacillus anthracis infection
2) Confidence 0.60 Published 2010 Journal PLoS Pathogens Section Abstract Doc Link PMC2987825 Disease Relevance 1.13 Pain Relevance 0.34
In this regard, an anti-CXCL10 antibody has been recently developed and shown to inhibit CXCR3+ T cell recruitment in an experimental model of lung inflammation (Hildebrandt et al 2004).


Localization (recruitment) of CXCR3 in lung associated with inflammation and pneumonia
3) Confidence 0.20 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707155 Disease Relevance 1.12 Pain Relevance 0.40

General Comments

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