INT17444

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Context Info
Confidence 0.66
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 5.17
Pain Relevance 3.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MTHFS) Golgi apparatus (MTHFS) plasma membrane (MTHFS)
ligase activity (MTHFS) cytoplasm (MTHFS)
Anatomy Link Frequency
colon 3
lymphocyte 1
uterine 1
platelet 1
gastrointestinal system 1
MTHFS (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 37 100.00 Very High Very High Very High
Inflammatory response 2 99.82 Very High Very High Very High
Inflammation 15 99.36 Very High Very High Very High
diclofenac 3 92.48 High High
COX-2 inhibitor 12 87.84 High High
aspirin 11 85.24 High High
Potency 4 83.92 Quite High
cytokine 6 68.08 Quite High
Inflammatory stimuli 1 40.48 Quite Low
Abeta 2 32.40 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 29 100.00 Very High Very High Very High
Infection 13 98.48 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 2 98.08 Very High Very High Very High
Disease 6 97.36 Very High Very High Very High
Toxicity 3 96.80 Very High Very High Very High
Syndrome 1 96.04 Very High Very High Very High
Colon Cancer 12 95.44 Very High Very High Very High
Cancer 53 95.36 Very High Very High Very High
Rheumatic Diseases 1 90.00 High High
Pre-term Labor 2 89.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is suggested that the phenylacetic acid derivative non-steroidal anti-inflammatory drugs may have a composite action in vivo: by inhibition of cyclo-oxygenase they reduce prostaglandin production (and so produce some symptomatic relief in the same manner as the drugs in the other chemical groups of non-steroidal anti-inflammatory agents) and by suppression of lymphocyte replication they may interfere with the pathogenesis of certain chronic rheumatic diseases.
Gene_expression (production) of cyclo-oxygenase in lymphocyte associated with inflammation, cinod and rheumatic diseases
1) Confidence 0.66 Published 1988 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 2460411 Disease Relevance 0.41 Pain Relevance 0.44
Cyclo-oxygenase exists in two different isoforms, cyclo-oxygenase-1 and cyclo-oxygenase-2, and data obtained during the last few years have suggested that cyclo-oxygenase-2 might be involved in both human and experimental colon carcinogenesis.
Gene_expression (exists) of Cyclo-oxygenase in colon
2) Confidence 0.49 Published 1997 Journal Ann. Med. Section Abstract Doc Link 9240630 Disease Relevance 0.34 Pain Relevance 0.44
Cyclo-oxygenase exists in two different isoforms, cyclo-oxygenase-1 and cyclo-oxygenase-2, and data obtained during the last few years have suggested that cyclo-oxygenase-2 might be involved in both human and experimental colon carcinogenesis.
Gene_expression (exists) of cyclo-oxygenase in colon
3) Confidence 0.49 Published 1997 Journal Ann. Med. Section Abstract Doc Link 9240630 Disease Relevance 0.34 Pain Relevance 0.44
Cyclo-oxygenase exists in two different isoforms, cyclo-oxygenase-1 and cyclo-oxygenase-2, and data obtained during the last few years have suggested that cyclo-oxygenase-2 might be involved in both human and experimental colon carcinogenesis.
Gene_expression (exists) of cyclo-oxygenase in colon
4) Confidence 0.49 Published 1997 Journal Ann. Med. Section Abstract Doc Link 9240630 Disease Relevance 0.34 Pain Relevance 0.44
Increased expression of the inducible isoform of cyclo-oxygenase (COX-2) and prostaglandin output from fetal membranes is a key stage in human parturition.
Gene_expression (expression) of cyclo-oxygenase
5) Confidence 0.49 Published 2003 Journal J Obstet Gynaecol Section Abstract Doc Link 12850850 Disease Relevance 0.15 Pain Relevance 0.28
Inhibition of constitutively expressed cyclo-oxygenase (COX-1) by NSAIDs is thought to play an important role is the gastrointestinal toxicity of NSAIDs.
Gene_expression (expressed) of cyclo-oxygenase associated with toxicity and cinod
6) Confidence 0.13 Published 1996 Journal Ital J Gastroenterol Section Abstract Doc Link 9032580 Disease Relevance 0.33 Pain Relevance 0.24
In PLT, orpanoxin (100 mumols/l) inhibited formation of cyclo-oxygenase products (thromboxanes, prostaglandins, and 12-L-hydroxy-5,8,10-heptadecatrienoic acid) and increased synthesis of the lipoxygenase product, 12S-hydroxy-5,8-cis,10-trans,14-cis-eicosatetraenoic acid.
Gene_expression (products) of cyclo-oxygenase
7) Confidence 0.07 Published 1988 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 3152163 Disease Relevance 0.08 Pain Relevance 0.17
BACKGROUND: Selective cyclo-oxygenase (COX)-2 inhibitors (coxibs) produce the beneficial effects of nonsteroidal anti-inflammatory drugs (NSAIDs) while sparing the COX-1-mediated adverse effects on platelets and the gastrointestinal system.
Gene_expression (produce) of cyclo-oxygenase in gastrointestinal system associated with inflammation and cinod
8) Confidence 0.05 Published 2002 Journal Can J Cardiol Section Abstract Doc Link 12518182 Disease Relevance 0.32 Pain Relevance 0.35
Cyclo-oxygenase exists in two isoforms (COX-1 and COX-2).
Gene_expression (exists) of Cyclo-oxygenase
9) Confidence 0.03 Published 2000 Journal Eur. J. Clin. Pharmacol. Section Abstract Doc Link 11009046 Disease Relevance 0.09 Pain Relevance 0.42
Microglial cyclo-oxygenase (COX) expression is considered to be important in the pathogenesis of Alzheimer's disease (AD) and, therefore, constitutes a key target for therapeutic intervention.
Gene_expression (expression) of cyclo-oxygenase associated with disease
10) Confidence 0.03 Published 2002 Journal Brain Res. Section Abstract Doc Link 12270500 Disease Relevance 0.61 Pain Relevance 0.03
The cyclo-oxygenase pathway, which is inhibited by nonsteroidal anti-inflammatory drugs, produces vasodilator prostaglandins such as PGE2 and prostacyclin (PGI2) and also thromboxane A4, a potent platelet aggregating agent.
Gene_expression (produces) of cyclo-oxygenase in platelet associated with inflammation and cinod
11) Confidence 0.02 Published 1991 Journal Z Rheumatol Section Abstract Doc Link 1907059 Disease Relevance 0.27 Pain Relevance 0.19
Cyclo-oxygenase (COX)-2 expression correlates directly with highly aggressive and metastatic breast cancer, but the mechanism underlying this correlation remains obscure.
Gene_expression (expression) of Cyclo-oxygenase associated with advanced or metastatic breast cancer
12) Confidence 0.01 Published 2006 Journal Breast Cancer Res Section Abstract Doc Link PMC1797025 Disease Relevance 0.37 Pain Relevance 0
The fact that NSAIDs inhibit the eicosanoid pathway prompted mechanistic drug-developmental work focusing on COX (cyclo-oxygenase) and its products.
Gene_expression (products) of cyclo-oxygenase associated with cinod
13) Confidence 0.01 Published 2005 Journal Biochem. Soc. Trans. Section Abstract Doc Link 16042585 Disease Relevance 0.68 Pain Relevance 0.37
Although it is a syndrome rather than a single condition, in >80% of the preterm deliveries <32 weeks of gestation there is intra-uterine infection that is subclinical where maternal and fetal inflammatory response-induced cyclo-oxygenase and placental prostaglandin synthesis lead to myometrial contractility and premature parturition [2].
Gene_expression (synthesis) of cyclo-oxygenase in uterine associated with inflammatory response, syndrome and infection
14) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2811723 Disease Relevance 0.82 Pain Relevance 0.05

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