INT174442

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Context Info
Confidence 0.17
First Reported 2003
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.63
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
bladder 6
tryptase (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 166 99.64 Very High Very High Very High
Osteoarthritis 50 71.00 Quite High
rheumatoid arthritis 102 70.72 Quite High
interstitial cystitis 9 67.48 Quite High
substance P 12 65.00 Quite High
agonist 4 64.96 Quite High
Inflammatory stimuli 16 58.80 Quite High
Inflammatory response 25 57.24 Quite High
Inflammatory mediators 3 17.52 Low Low
cytokine 10 9.92 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 206 99.64 Very High Very High Very High
Cystitis 28 96.72 Very High Very High Very High
Osteoarthritis 50 71.00 Quite High
Rheumatoid Arthritis 102 70.72 Quite High
Interstitial Cystitis 9 67.48 Quite High
Microphthalmia 46 63.12 Quite High
Carcinoma 12 48.88 Quite Low
Pressure And Volume Under Development 3 46.24 Quite Low
Mastocytosis 2 37.92 Quite Low
Adhesions 6 34.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment for MC tryptase staining involved 5 min incubation with 0.1% pronase (Sigma, St.
Positive_regulation (Pretreatment) of Gene_expression (staining) of tryptase
1) Confidence 0.17 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 0.14 Pain Relevance 0.07
However, to the best of our knowledge, there is no information regarding which particular tryptase is expressed in the mouse bladder and/or upregulated in this mouse model during inflammation.
Positive_regulation (upregulated) of Gene_expression (expressed) of tryptase in bladder associated with inflammation
2) Confidence 0.13 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853108 Disease Relevance 0.28 Pain Relevance 0.20
However, to the best of our knowledge, there is no information regarding which particular tryptase is expressed in the mouse bladder and/or upregulated in the mouse model during inflammation.
Positive_regulation (upregulated) of Gene_expression (expressed) of tryptase in bladder associated with inflammation
3) Confidence 0.03 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.27 Pain Relevance 0.16
PARs provide an answer to the question of how mast cell products, such as tryptase, produce signals and induce bladder inflammation.
Positive_regulation (induce) of Gene_expression (produce) of tryptase in bladder associated with inflammation
4) Confidence 0.03 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.94 Pain Relevance 0.44

General Comments

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