INT174446

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Context Info
Confidence 0.33
First Reported 2003
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 7
Total Number 11
Disease Relevance 5.47
Pain Relevance 2.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Smcp) cytoplasm (Smcp)
Anatomy Link Frequency
synovial fluid 1
capsule 1
skin 1
Smcp (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 306 99.96 Very High Very High Very High
Inflammation 88 99.52 Very High Very High Very High
Glutamate 4 90.12 High High
Enkephalin 6 89.56 High High
neuropeptide release 24 89.12 High High
Neurotransmitter 15 87.64 High High
Mechanotransduction 15 85.68 High High
Neuropeptide 24 80.40 Quite High
fortral 16 80.28 Quite High
agonist 7 79.68 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 312 99.96 Very High Very High Very High
INFLAMMATION 88 99.52 Very High Very High Very High
Melanoma 252 96.52 Very High Very High Very High
Cancer 141 95.96 Very High Very High Very High
Necrosis 13 95.72 Very High Very High Very High
Sprains And Strains 28 94.48 High High
Apoptosis 198 91.68 High High
Pressure And Volume Under Development 9 85.84 High High
Malignant Neoplastic Disease 16 84.68 Quite High
Toxicity 20 83.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, rimcazole appears to synergize the activity of anti-MCSP:TRAIL by promoting caspase-8 activation.
Spec (appears) Positive_regulation (synergize) of anti-MCSP
1) Confidence 0.33 Published 2010 Journal Mol Cancer Section Body Doc Link PMC3000402 Disease Relevance 0.64 Pain Relevance 0.16
Anti-MCSP:TRAIL activity was further synergized by co-treatment with rimcazole, a ?
Positive_regulation (synergized) of Anti-MCSP
2) Confidence 0.33 Published 2010 Journal Mol Cancer Section Abstract Doc Link PMC3000402 Disease Relevance 1.01 Pain Relevance 0.03
The MCSP antibody fragment used in this study was derived from mAb 9.2.27.
Positive_regulation (derived) of MCSP
3) Confidence 0.29 Published 2010 Journal Mol Cancer Section Body Doc Link PMC3000402 Disease Relevance 0.53 Pain Relevance 0
Intriguingly, cross-linking of MCSP by bead-coated mAb 9.2.27 has also been used to achieve activation of MCSP-signaling [6].
Positive_regulation (activation) of MCSP-signaling
4) Confidence 0.29 Published 2010 Journal Mol Cancer Section Body Doc Link PMC3000402 Disease Relevance 0 Pain Relevance 0
MCs were followed for over four weeks in culture, but proliferating CK20-positive cells were detected only during the first two weeks after enrichment.
Positive_regulation (followed) of MCs
5) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722079 Disease Relevance 0 Pain Relevance 0
To confirm this result, we stimulated MCs by treatment with 4?
Positive_regulation (stimulated) of MCs
6) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722079 Disease Relevance 0.09 Pain Relevance 0.19
Activated MCs are characterized by degranulation of inflammatory and proteolytic molecules (histamine, proteases, tumor necrosis factor-?)
Positive_regulation (Activated) of MCs associated with necrosis, inflammation and cancer
7) Confidence 0.15 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.25 Pain Relevance 0.56
Indeed, apart from macrophages, lymphocytes, fibroblasts and neutrophils, which are considered to be important contributors to the pathogenesis of RA, increased numbers of MCs are found in the synovial tissue and synovial fluid of RA patients [44,45].
Positive_regulation (increased) of MCs in synovial fluid associated with rheumatoid arthritis
8) Confidence 0.15 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 0.65 Pain Relevance 0.32
Finally, we suggest that either vessel-derived MC precursors express CXCR3 a priori and become recruited to sites of inflammation, or that mature tissue MCs become activated within RA synovial tissue and upregulate CXCR3 secondarily in response to signals from the proinflammatory trigger.
Positive_regulation (activated) of MCs associated with inflammation and rheumatoid arthritis
9) Confidence 0.15 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.21 Pain Relevance 0.60
Through the release of VIP following histamine stimulation and activation of TRPV4, MCs probably act in skin pathophysiology, but their exact role remains to be defined.
Positive_regulation (activation) of MCs in skin
10) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722079 Disease Relevance 0 Pain Relevance 0.37
To test for the presence of lipid A in the capsule, various preparations of capsule were generated and analyzed by mass spectrometry.
Spec (analyzed) Positive_regulation (generated) of capsule in capsule
11) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2897883 Disease Relevance 0.09 Pain Relevance 0

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