INT174447

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Context Info
Confidence 0.60
First Reported 2003
Last Reported 2008
Negated 1
Speculated 2
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.68
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cxcr3) plasma membrane (Cxcr3) signal transducer activity (Cxcr3)
Anatomy Link Frequency
leukocyte 1
Cxcr3 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 102 98.88 Very High Very High Very High
interstitial cystitis 82 98.72 Very High Very High Very High
Inflammation 72 96.84 Very High Very High Very High
chemokine 53 95.60 Very High Very High Very High
cytokine 36 94.28 High High
Osteoarthritis 50 88.64 High High
Arthritis 7 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
Lasting pain 2 5.00 Very Low Very Low Very Low
Multiple sclerosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cystitis 140 99.48 Very High Very High Very High
Rheumatoid Arthritis 102 98.88 Very High Very High Very High
Interstitial Cystitis 82 98.72 Very High Very High Very High
INFLAMMATION 72 96.84 Very High Very High Very High
Disease 45 96.52 Very High Very High Very High
Osteoarthritis 50 88.64 High High
Pressure And Volume Under Development 2 63.04 Quite High
Hyperplasia 9 5.00 Very Low Very Low Very Low
Arthritis 8 5.00 Very Low Very Low Very Low
Cancer 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Unaffected mice treated with either control or anti-CXCL10 Abs showed no significant change in serum CXCR3 ligand levels.
Neg (no) Regulation (change) of CXCR3
1) Confidence 0.60 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.96 Pain Relevance 0.24
Alterations in serum CXCR3 ligand levels were examined in interstitial cystitis (IC) patients; similar expression patterns in serum as well as CXCR3, CXCR3 ligands, and cytokines expressed by peripheral and local leukocyte subpopulations were characterized during cyclophosphamide (CYP)-induced acute cystitis in mice.


Spec (examined) Regulation (Alterations) of CXCR3 in leukocyte associated with cystitis, interstitial cystitis and cytokine
2) Confidence 0.26 Published 2008 Journal J Immune Based Ther Vaccines Section Abstract Doc Link PMC2583981 Disease Relevance 0.50 Pain Relevance 0.30
Among the RA synovial tissue samples examined for CXCR1, CXCR2, and CXCR3 immunoreactivity, 8 out of 20 specimens exhibited heterogeneous histologic changes in terms of inflammatory infiltration in sublining regions.
Spec (examined) Regulation (immunoreactivity) of CXCR3 associated with inflammation and rheumatoid arthritis
3) Confidence 0.26 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.23 Pain Relevance 0.57

General Comments

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