INT174453

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Context Info
Confidence 0.17
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.29
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cxcr3) mitochondrion (Smcp) plasma membrane (Cxcr3)
signal transducer activity (Cxcr3) cytoplasm (Smcp)
Smcp (Mus musculus)
Cxcr3 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 102 100.00 Very High Very High Very High
Inflammation 24 99.52 Very High Very High Very High
Osteoarthritis 50 65.76 Quite High
Arthritis 7 65.52 Quite High
chemokine 29 59.60 Quite High
cytokine 8 38.08 Quite Low
fibrosis 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 102 100.00 Very High Very High Very High
INFLAMMATION 24 99.52 Very High Very High Very High
Cancer 3 85.28 High High
Necrosis 3 84.80 Quite High
Osteoarthritis 50 65.76 Quite High
Arthritis 8 65.52 Quite High
Sprains And Strains 1 28.12 Quite Low
Disease 13 5.00 Very Low Very Low Very Low
Adhesions 4 5.00 Very Low Very Low Very Low
Hyperplasia 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, we suggest that either vessel-derived MC precursors express CXCR3 a priori and become recruited to sites of inflammation, or that mature tissue MCs become activated within RA synovial tissue and upregulate CXCR3 secondarily in response to signals from the proinflammatory trigger.
MCs Positive_regulation (upregulate) of CXCR3 associated with inflammation and rheumatoid arthritis
1) Confidence 0.17 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.29 Pain Relevance 0.64

General Comments

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