INT174468

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Context Info
Confidence 0.40
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 1.88
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL7, IL4) extracellular region (IL7, IL4) cell-cell signaling (IL7)
Anatomy Link Frequency
T cells 2
IL7 (Homo sapiens)
IL4 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 216 99.04 Very High Very High Very High
Inflammation 24 92.56 High High
cytokine 32 92.08 High High
Inflammatory stimuli 4 88.32 High High
Inflammatory response 12 5.00 Very Low Very Low Very Low
Arthritis 8 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 216 99.04 Very High Very High Very High
INFLAMMATION 44 92.56 High High
Disease 24 5.00 Very Low Very Low Very Low
Arthritis 12 5.00 Very Low Very Low Very Low
Cancer 4 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The percentage increase in IL-4 production after differentiation by IL-7 and IL-4 was higher in RA patients than in healthy controls.
IL-7 Positive_regulation (increase) of Gene_expression (production) of IL-4 associated with rheumatoid arthritis
1) Confidence 0.40 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193727 Disease Relevance 0.65 Pain Relevance 0.32
production was differentially regulated by IL-7 and IL-4, but IL-4 production was increased by both IL-7 and IL-4.
IL-7 Positive_regulation (increased) of Gene_expression (production) of IL-4
2) Confidence 0.27 Published 2003 Journal Arthritis Res Ther Section Abstract Doc Link PMC193727 Disease Relevance 0.51 Pain Relevance 0.25
CD3/CD28 costimulation and IL-7 were early inducers of IL-4 production, but primarily stimulated IFN-?
IL-7 Positive_regulation (inducers) of Gene_expression (production) of IL-4
3) Confidence 0.27 Published 2003 Journal Arthritis Res Ther Section Abstract Doc Link PMC193727 Disease Relevance 0.38 Pain Relevance 0.19
Short-term costimulation with CD3/CD28 and IL-7 but not with IL-4 induces IL-4 production in naive CD4+ T cells
IL-7 Positive_regulation (induces) of Gene_expression (production) of IL-4 in T cells
4) Confidence 0.27 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193727 Disease Relevance 0.34 Pain Relevance 0.26

General Comments

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