INT174476

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Context Info
Confidence 0.34
First Reported 2003
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.67
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CD28) plasma membrane (CD28)
CD28 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 9 94.60 High High
rheumatoid arthritis 57 88.44 High High
cytokine 54 63.72 Quite High
Inflammatory response 4 55.04 Quite High
Inflammation 60 51.80 Quite High
Arthritis 3 35.84 Quite Low
abatacept 3 19.36 Low Low
Inflammatory stimuli 11 5.00 Very Low Very Low Very Low
COX2 4 5.00 Very Low Very Low Very Low
member 8 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 57 88.44 High High
Cancer 7 69.44 Quite High
Necrosis 4 68.96 Quite High
INFLAMMATION 76 55.04 Quite High
Arthritis 4 35.84 Quite Low
Lymphatic System Cancer 7 35.44 Quite Low
Disease 10 31.20 Quite Low
Renal Disease 10 5.00 Very Low Very Low Very Low
Death 8 5.00 Very Low Very Low Very Low
Infection 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CD28 levels do not seem to be modulated by WJMSCs.
Regulation (modulated) of CD28
1) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2814860 Disease Relevance 0.05 Pain Relevance 0.08
One of the first tools used to target the B7/CD28 pathway was the CTLA4-Ig molecule, a fusion protein consisting of the extracellular domain of CTLA-4 and the Fc domain of IgG.
Regulation (target) of B7/CD28
2) Confidence 0.33 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721321 Disease Relevance 0 Pain Relevance 0.05
In the absence of CD3/CD28 costimulation or less optimal stimulatory conditions (data not shown), we and other workers have found that IL-7 increases primarily IFN-?
Regulation (absence) of CD3/CD28
3) Confidence 0.30 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193727 Disease Relevance 0.62 Pain Relevance 0.24
Other cell surface receptors, for example CD28, analyzed in parallel on the same cells were unaffected by Trx1 treatment (Figure 5C, right panel).
Neg (unaffected) Spec (analyzed) Regulation (unaffected) of CD28
4) Confidence 0.09 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0 Pain Relevance 0

General Comments

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