INT174477

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Context Info
Confidence 0.47
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 10.35
Pain Relevance 3.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL7) extracellular region (IL7) cell-cell signaling (IL7)
Anatomy Link Frequency
lymphocyte 2
T-cell 2
bone marrow 1
IL7 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 128 100.00 Very High Very High Very High
rheumatoid arthritis 1152 99.92 Very High Very High Very High
Inflammation 87 98.24 Very High Very High Very High
Osteoarthritis 18 65.12 Quite High
Multiple sclerosis 9 63.20 Quite High
chemokine 4 56.32 Quite High
Inflammatory mediators 4 50.00 Quite Low
Inflammatory response 9 36.24 Quite Low
cINOD 11 5.00 Very Low Very Low Very Low
corticosteroid 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 1152 99.92 Very High Very High Very High
Lymphopenia 153 98.68 Very High Very High Very High
INFLAMMATION 112 98.24 Very High Very High Very High
Increased Venous Pressure Under Development 18 96.36 Very High Very High Very High
Cancer 182 95.20 Very High Very High Very High
Recurrence 9 94.96 High High
Infection 23 92.24 High High
Solid Tumor 36 91.32 High High
Fever 79 87.20 High High
Disease 201 82.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study we demonstrated reduced levels of circulating IL-7 in a cross-section of RA patients.
Negative_regulation (reduced) of IL-7 associated with rheumatoid arthritis
1) Confidence 0.47 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1064881 Disease Relevance 1.03 Pain Relevance 0.33
To investigate whether such an IL-7 deficiency could account for the prolonged lymphopenia observed in RA following therapeutic lymphodepletion, we compared RA patients and patients with solid cancers treated with high-dose chemotherapy and autologous progenitor cell rescue.
Negative_regulation (deficiency) of IL-7 associated with lymphopenia, cancer and rheumatoid arthritis
2) Confidence 0.35 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1064881 Disease Relevance 1.15 Pain Relevance 0.37
Interleukin-7 deficiency in rheumatoid arthritis: consequences for therapy-induced lymphopenia

We previously demonstrated prolonged, profound CD4+ T-lymphopenia in rheumatoid arthritis (RA) patients following lymphocyte-depleting therapy.

Negative_regulation (deficiency) of Interleukin-7 in lymphocyte associated with lymphopenia and rheumatoid arthritis
3) Confidence 0.35 Published 2005 Journal Arthritis Res Ther Section Title Doc Link PMC1064881 Disease Relevance 0.99 Pain Relevance 0.31
Figure 4 clearly demonstrates a four- to fivefold rise and subsequent decrease in IL-7 levels, coincident with short-term lymphopenia in non-RA patients (triangles).
Negative_regulation (decrease) of IL-7 associated with lymphopenia and rheumatoid arthritis
4) Confidence 0.35 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064881 Disease Relevance 1.16 Pain Relevance 0.41
IL-7 deficiency may again be relevant.
Negative_regulation (deficiency) of IL-7
5) Confidence 0.35 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064881 Disease Relevance 0.86 Pain Relevance 0.19
Our data therefore suggest that RA patients are relatively IL-7 deficient and that this deficiency is likely to be an important contributing factor to poor early T-cell reconstitution in RA following therapeutic lymphodepletion.
Negative_regulation (deficient) of IL-7 in T-cell associated with rheumatoid arthritis
6) Confidence 0.35 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1064881 Disease Relevance 1.36 Pain Relevance 0.48
Importantly, the RA thymus is capable of producing naïve T-cells but its function is compromised by an IL-7 deficiency.
Negative_regulation (deficiency) of IL-7 in T-cells associated with rheumatoid arthritis
7) Confidence 0.35 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064881 Disease Relevance 1.21 Pain Relevance 0.43
Therefore, although we cannot definitively exclude alternative explanations for reduced IL-7 levels, low levels in lymphopenic RA patients (Fig. 4) and the variable ability to recover IL-7 in remission (Fig. 5) strongly implicate an underlying defect in IL-7 regulation, also highlighted by the bone marrow derived stromal culture (Fig. 1).
Negative_regulation (reduced) of IL-7 in bone marrow associated with rheumatoid arthritis
8) Confidence 0.35 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064881 Disease Relevance 0.67 Pain Relevance 0.22
In contrast, we found that basal serum IL-7 levels were reduced in a range of RA patients, irrespective of inflammation or medication (Fig. 1b).
Negative_regulation (reduced) of IL-7 associated with inflammation and rheumatoid arthritis
9) Confidence 0.35 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064881 Disease Relevance 0.93 Pain Relevance 0.22
With respect to the increase of IL-4, the combination was significantly additive to the effect of either IL-7 or IL-4 alone.


Negative_regulation (effect) of IL-7
10) Confidence 0.27 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193727 Disease Relevance 0.38 Pain Relevance 0.19
The lymphocyte-specific cytokine, IL7, and CD4+ T-helper cytokine, IL17, were suppressed in both AFP and FP sera compared to controls (Figure 4A and Additional File 4, Table S3).
Negative_regulation (suppressed) of IL7 in lymphocyte associated with cytokine
11) Confidence 0.26 Published 2010 Journal BMC Pediatr Section Body Doc Link PMC2944328 Disease Relevance 0.59 Pain Relevance 0.53

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