INT174478

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Context Info
Confidence 0.34
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 3.56
Pain Relevance 1.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL4) extracellular region (IL4)
Anatomy Link Frequency
T cells 8
lymphocytes 2
IL4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 410 100.00 Very High Very High Very High
rheumatoid arthritis 54 99.84 Very High Very High Very High
agonist 80 99.60 Very High Very High Very High
antagonist 136 99.16 Very High Very High Very High
aspirin 4 94.28 High High
Inflammation 414 90.32 High High
chemokine 92 88.84 High High
Neuritis 2 77.00 Quite High
withdrawal 8 62.76 Quite High
Inflammatory response 27 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 1260 99.84 Very High Very High Very High
Rheumatoid Arthritis 54 99.84 Very High Very High Very High
Metaplasia 24 94.92 High High
Eosinophilia 76 92.00 High High
Pneumonia 28 91.12 High High
Occupational Lung Diseases 60 84.64 Quite High
Neuritis 2 77.00 Quite High
Colitis 6 76.04 Quite High
INFLAMMATION 447 71.40 Quite High
Graft Vs Host Disease 4 70.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Differentiation of naive CD4+ T cells by IL-7 and IL-4 is not impaired in RA patients
Negative_regulation (impaired) of Localization (Differentiation) of IL-4 in T cells associated with rheumatoid arthritis
1) Confidence 0.34 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193727 Disease Relevance 0.46 Pain Relevance 0.23
Furthermore, in vitro, glucocorticoids inhibit proliferation and IL-4 and IL-5 secretion by human allergen-specific Th2 lymphocytes [17].
Negative_regulation (inhibit) of Localization (secretion) of IL-4 in lymphocytes
2) Confidence 0.18 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.22 Pain Relevance 0.08
These data support the potential utility of a dual IL-4 and IL-13 oligonucleotide inhibitor in asthma, and suggest that local inhibition of IL-4R?
Negative_regulation (inhibitor) of Localization (utility) of IL-4 associated with asthma
3) Confidence 0.18 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 1.01 Pain Relevance 0.23
2-agonists have been shown to inhibit the secretion of IL-4 and IL-5 in T cell lines [45].
Negative_regulation (inhibit) of Localization (secretion) of IL-4 in T cell associated with agonist
4) Confidence 0.18 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.56 Pain Relevance 0.45
In vitro, the cysteinyl-leukotriene receptor antagonist pranlukast can concentration-dependently inhibit the release of Th2 cytokines (IL-3, IL-4, GM-CSF), but not of the Th1 cytokine IL-2, from mite allergen-stimulated PBMCs from asthmatic patients [37].
Negative_regulation (inhibit) of Localization (release) of IL-4 associated with asthma, antagonist and cytokine
5) Confidence 0.18 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.73 Pain Relevance 0.42
T cells for 96hrs with pbCD3/sCD28 in presence or absence of IL-4 or TGF-?
Negative_regulation (96hrs) of Localization (presence) of IL-4 in T cells
6) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0.29 Pain Relevance 0.12
T cells for 96hrs with pbCD3/sCD28 in presence or absence of IL-4 or TGF-?
Negative_regulation (absence) of Localization (presence) of IL-4 in T cells
7) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0.29 Pain Relevance 0.12

General Comments

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