INT174480

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Context Info
Confidence 0.38
First Reported 2003
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 4.55
Pain Relevance 1.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL7) extracellular region (IL7) cell-cell signaling (IL7)
Anatomy Link Frequency
T cells 2
IL7 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 40 100.00 Very High Very High Very High
rheumatoid arthritis 474 99.76 Very High Very High Very High
Multiple sclerosis 3 99.36 Very High Very High Very High
Inflammation 33 83.60 Quite High
Inflammatory response 6 38.88 Quite Low
Arthritis 4 19.68 Low Low
Osteoarthritis 6 5.00 Very Low Very Low Very Low
cINOD 5 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
methotrexate 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 474 99.76 Very High Very High Very High
Lymphoproliferative Disease 3 99.76 Very High Very High Very High
Disease 69 99.40 Very High Very High Very High
Demyelinating Disease 3 99.36 Very High Very High Very High
Lymphopenia 51 86.36 High High
INFLAMMATION 46 83.60 Quite High
Cancer 62 75.40 Quite High
Congenital Anomalies 9 67.32 Quite High
Hematological Disease 6 65.28 Quite High
Toxicity 3 60.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To date, IL-7 is not a cytokine that has been associated with RA.
IL-7 Binding (associated) of associated with rheumatoid arthritis and cytokine
1) Confidence 0.38 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064881 Disease Relevance 1.60 Pain Relevance 0.53
For example, IL-7 has been associated with preferential expansion [62] and activation [63] of autoreactive T-cells in multiple sclerosis.
IL-7 Binding (associated) of in T-cells associated with multiple sclerosis
2) Confidence 0.29 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064881 Disease Relevance 1.10 Pain Relevance 0.42
Additionally, IL-7 has been associated with lymphoproliferative disorders [64-66] to which RA patients are already predisposed.
IL-7 Binding (associated) of associated with rheumatoid arthritis and lymphoproliferative disease
3) Confidence 0.29 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064881 Disease Relevance 1.10 Pain Relevance 0.41
The combination of IL-7 and IL-4 reduced IFN-?
IL-7 Binding (combination) of
4) Confidence 0.23 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193727 Disease Relevance 0.21 Pain Relevance 0.10
Although we show that IL-7, and in particular the combination of IL-7 and IL-4, increased Th2 activity rather than Th1 activity of naive CD4+ T cells, this was only found under conditions where IFN-?
IL-7 Binding (combination) of in T cells
5) Confidence 0.23 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193727 Disease Relevance 0.54 Pain Relevance 0.22

General Comments

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