INT174481

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Context Info
Confidence 0.56
First Reported 2003
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 6.19
Pain Relevance 2.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL7) extracellular region (IL7) cell-cell signaling (IL7)
Anatomy Link Frequency
juvenile 2
T cell 2
IL7 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 752 99.84 Very High Very High Very High
cytokine 115 98.76 Very High Very High Very High
Arthritis 28 97.68 Very High Very High Very High
Inflammatory response 3 95.00 High High
Inflammation 85 84.80 Quite High
cINOD 7 72.08 Quite High
Kinase C 1 71.56 Quite High
methotrexate 10 69.04 Quite High
antagonist 4 54.56 Quite High
chemokine 17 51.84 Quite High
Disease Link Frequency Relevance Heat
Lymphopenia 92 100.00 Very High Very High Very High
Rheumatoid Arthritis 755 99.84 Very High Very High Very High
Arthritis 19 97.68 Very High Very High Very High
Disease 170 95.36 Very High Very High Very High
INFLAMMATION 96 94.64 High High
Cancer 118 87.72 High High
Necrosis 16 87.52 High High
Death 15 72.08 Quite High
Hematological Disease 10 61.48 Quite High
Increased Venous Pressure Under Development 10 54.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Most importantly, there was no increase in serum IL-7 levels in RA, as compared with a fourfold rise in non-RA control individuals at the time of lymphopenia.
Neg (no) Positive_regulation (increase) of Gene_expression (levels) of IL-7 associated with lymphopenia and rheumatoid arthritis
1) Confidence 0.56 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1064881 Disease Relevance 1.38 Pain Relevance 0.49
Lymphopenia-induced interleukin-7 production is defective in rheumatoid arthritis
Positive_regulation (-) of Gene_expression (production) of interleukin-7 associated with lymphopenia and rheumatoid arthritis
2) Confidence 0.56 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064881 Disease Relevance 0.78 Pain Relevance 0.25
Circulating IL-7 levels (Fig. 1a) were significantly lower in RA patients than in healthy control individuals (P < 0.00001).
Positive_regulation (Circulating) of Gene_expression (levels) of IL-7 associated with rheumatoid arthritis
3) Confidence 0.40 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064881 Disease Relevance 0.81 Pain Relevance 0.44
Lymphopenia-induced interleukin-7 production is defective in rheumatoid arthritis
Positive_regulation (induced) of Gene_expression (production) of interleukin-7 associated with lymphopenia and rheumatoid arthritis
4) Confidence 0.37 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064881 Disease Relevance 0.78 Pain Relevance 0.25
IL-7 expression is upregulated or downregulated by different cytokines in different tissues (transforming growth factor-?
Positive_regulation (upregulated) of Gene_expression (expression) of IL-7 associated with cytokine
5) Confidence 0.37 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064881 Disease Relevance 0.52 Pain Relevance 0.22
Despite continued administration of rhIL-7 through day 14 resulting in sustained increases in circulating IL-7 levels (Fig.
Positive_regulation (increases) of Gene_expression (levels) of IL-7
6) Confidence 0.34 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442646 Disease Relevance 0.12 Pain Relevance 0.04
Thus, rhIL-7 therapy leads to transient, widespread T cell cycling that is tightly regulated by IL-7R?
Positive_regulation (leads) of Gene_expression (therapy) of rhIL-7 in T cell
7) Confidence 0.30 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442646 Disease Relevance 0.05 Pain Relevance 0.03
Increased levels of circulating IL-7 in patients with RA and juvenile idiopathic (rheumatoid) arthritis [30,33] correlated with increased parameters of disease.
Positive_regulation (Increased) of Gene_expression (levels) of IL-7 in juvenile associated with rheumatoid arthritis, disease and arthritis
8) Confidence 0.29 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193727 Disease Relevance 1.14 Pain Relevance 0.36
High levels of IL-7 and IL-15 mRNA and protein expression have been demonstrated in synovial tissue cells from RA patients [41].
Positive_regulation (levels) of Gene_expression (expression) of IL-7 associated with rheumatoid arthritis
9) Confidence 0.05 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 0.61 Pain Relevance 0.40

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