INT174482

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Context Info
Confidence 0.64
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.84
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL7) extracellular region (IL7) cell-cell signaling (IL7)
Anatomy Link Frequency
T cell 2
stromal cell 1
IL7 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 352 98.84 Very High Very High Very High
Inflammatory stimuli 2 67.00 Quite High
Inflammation 26 64.56 Quite High
methotrexate 2 51.64 Quite High
cINOD 4 51.08 Quite High
cytokine 39 50.60 Quite High
Inflammatory response 6 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
Osteoarthritis 4 5.00 Very Low Very Low Very Low
iatrogenic 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 50 98.94 Very High Very High Very High
Rheumatoid Arthritis 353 98.84 Very High Very High Very High
Lymphopenia 37 86.32 High High
Recurrence 2 78.76 Quite High
INFLAMMATION 38 66.68 Quite High
Cancer 48 6.64 Low Low
Solid Tumor 8 5.00 Very Low Very Low Very Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 7 5.00 Very Low Very Low Very Low
Necrosis 6 5.00 Very Low Very Low Very Low
Congenital Anomalies 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In RA patients whose disease was controlled by in vivo TNF blockade, spontaneous release of IL-7 from bone marrow derived stromal cell cultures was variable, remaining reduced in some patients but returning to normal in others (Fig. 1).
Localization (release) of IL-7 in stromal cell associated with rheumatoid arthritis and disease
1) Confidence 0.64 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064881 Disease Relevance 1.26 Pain Relevance 0.36
Whereas RA PBMCs responded suboptimally to IL-2, mitogen (PHA) or antigen (anti-CD3/CD28), as previously documented [39], their response to IL-7 was similar to that in control individuals (Fig. 1d).
Localization (response) of IL-7 associated with rheumatoid arthritis
2) Confidence 0.60 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064881 Disease Relevance 0.73 Pain Relevance 0.42
Differentiation of naive CD4+ T cells by IL-7 and IL-4 is not impaired in RA patients
Localization (Differentiation) of IL-7 in T cells associated with rheumatoid arthritis
3) Confidence 0.47 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193727 Disease Relevance 0.40 Pain Relevance 0.20
To determine whether the effects of rhIL-7 therapy on TCR repertoire diversity could be explained by varied effects among peripheral T cell subsets with differential IL-7R?
Localization (therapy) of rhIL-7 in T cell
4) Confidence 0.45 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442646 Disease Relevance 0 Pain Relevance 0
production, both in the absence of and in the presence of IL-7 (Fig. 1).
Localization (presence) of IL-7
5) Confidence 0.44 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193727 Disease Relevance 0.46 Pain Relevance 0.25

General Comments

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