INT174485

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Context Info
Confidence 0.96
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.17
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
cartilage 1
IFNA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 133 99.84 Very High Very High Very High
metalloproteinase 69 83.04 Quite High
Arthritis 51 80.32 Quite High
Inflammatory response 3 80.24 Quite High
Inflammation 29 78.32 Quite High
cytokine 24 61.28 Quite High
imagery 1 39.40 Quite Low
Pain 2 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Inflammatory marker 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 133 99.84 Very High Very High Very High
Infection 32 91.40 High High
Injury 4 85.12 High High
Disease 33 84.00 Quite High
Arthritis 55 80.32 Quite High
INFLAMMATION 26 79.84 Quite High
Coagulation Disorder 1 67.24 Quite High
Dengue 63 50.00 Quite Low
Frailty 2 42.40 Quite Low
Dengue Hemorrhagic Fever 67 36.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
activated RA FLS to degrade intact cartilage matrix and that IFN-?
Protein_catabolism (degrade) of IFN in cartilage associated with rheumatoid arthritis
1) Confidence 0.96 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888198 Disease Relevance 1.07 Pain Relevance 0.74
In contrast, when we examined differentially expressed genes from the in vitro studies, we found up-regulated genes that were over-represented in the processes of interferon-mediated immunity, proteolysis, and immunity and defense (Table S10).
Protein_catabolism (proteolysis) of interferon
2) Confidence 0.23 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2886038 Disease Relevance 0.34 Pain Relevance 0
Based on analysis of IFN-?
Protein_catabolism (analysis) of IFN
3) Confidence 0.20 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193727 Disease Relevance 0.76 Pain Relevance 0.37

General Comments

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