INT174486

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Context Info
Confidence 0.36
First Reported 2003
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 12
Total Number 15
Disease Relevance 6.09
Pain Relevance 1.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CD4) cell adhesion (CD4) plasma membrane (CD4)
enzyme binding (CD4)
Anatomy Link Frequency
T cell 14
neutrophils 3
lymphocytes 1
CD4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 134 100.00 Very High Very High Very High
addiction 134 100.00 Very High Very High Very High
rheumatoid arthritis 60 100.00 Very High Very High Very High
Osteoarthritis 4 43.44 Quite Low
metalloproteinase 4 42.56 Quite Low
agonist 4 33.76 Quite Low
Inflammation 154 28.72 Quite Low
Abeta 24 5.00 Very Low Very Low Very Low
Central nervous system 16 5.00 Very Low Very Low Very Low
fibrosis 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 61 100.00 Very High Very High Very High
Disease 95 99.90 Very High Very High Very High
Anaplastic Astrocytoma 4 99.64 Very High Very High Very High
Infection 358 98.20 Very High Very High Very High
Sarcoma 195 95.68 Very High Very High Very High
Contagious Ecthyma 61 94.64 High High
Breast Cancer 4 92.72 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 477 92.48 High High
Opportunistic Infections 1 89.56 High High
Noninfiltrating Intraductal Carcinoma 2 88.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
production of CD4+ T cells in RA patients by IL-7 alone, by IL-4 alone or by IL-7 and IL-4 was not significantly different from healthy controls (Fig. 3, left panel).
Neg (not) Regulation (different) of Gene_expression (production) of CD4 in T cells associated with rheumatoid arthritis
1) Confidence 0.36 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193727 Disease Relevance 0.64 Pain Relevance 0.32
Human astroglioma U87 cells stably transfected for the expression of human CD4 and CXCR4 (obtained through the ARRRP from Drs.
Regulation (transfected) of Gene_expression (expression) of CD4 associated with anaplastic astrocytoma
2) Confidence 0.32 Published 2008 Journal Retrovirology Section Body Doc Link PMC2576352 Disease Relevance 0.57 Pain Relevance 0.03
Analysis of CD4 and CCR5 dependence
Regulation (Analysis) of Gene_expression (dependence) of CD4 associated with addiction
3) Confidence 0.32 Published 2008 Journal Retrovirology Section Body Doc Link PMC2576352 Disease Relevance 0.31 Pain Relevance 0.12
TCR diversity spectratype analysis was performed on sorted CD4+ and CD8+ populations before and after (day 21) rhIL-7 therapy in 6 subjects treated at either 30 or 60 ?
Regulation (performed) of Gene_expression (populations) of CD4
4) Confidence 0.31 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442646 Disease Relevance 0 Pain Relevance 0
g of HBsAg was equivalent in terms of CD4+ T cell responses to injecting 20 ?
Regulation (terms) of Gene_expression (responses) of CD4 in T cell
5) Confidence 0.30 Published 2007 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1852106 Disease Relevance 0.13 Pain Relevance 0.07
In groups receiving IMP321, an increase in the frequency of specific CD4+ T cells producing Th1-type cytokines was observed in 2 subjects (25 %) in the 3 and 10 ?
Regulation (frequency) of Gene_expression (cytokines) of CD4 in T cells associated with cytokine
6) Confidence 0.30 Published 2007 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1852106 Disease Relevance 0.06 Pain Relevance 0.13
There was a significant route-dependence of the CD4+ T cell response with a higher rate of responders in the combined IM groups versus the combined ID groups (p?
Regulation (dependence) of Gene_expression (response) of CD4 in T cell associated with addiction
7) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981570 Disease Relevance 0.23 Pain Relevance 0.13
These data show that MVA-CMDR was immunogenic eliciting predominantly CD4+ responses as measured by IL-2 and IFN?
Regulation (eliciting) of Gene_expression (responses) of CD4
8) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981570 Disease Relevance 0.12 Pain Relevance 0.17
These data show that MVA-CMDR was immunogenic eliciting predominantly CD4+ responses as measured by IL-2 and IFN?
Regulation (show) of Gene_expression (responses) of CD4
9) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981570 Disease Relevance 0.12 Pain Relevance 0.18
The functional importance of CD4 expression by these cell types and the precise role these cell types play during retroviral infection is not yet fully understood.
Regulation (importance) of Gene_expression (expression) of CD4 associated with infection
10) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929209 Disease Relevance 0.50 Pain Relevance 0
In a study of seroconversions in Amsterdam, Goudsmit et al. found that CD4+ T-cell levels did not affect the rate of seroconversions, but once HHV-8 infection had occurred, a decline in CD4+ cells was associated with increasing reactivity against the Orf 65 antigen [46].
Neg (not) Regulation (affect) of Gene_expression (levels) of CD4 in T-cell associated with contagious ecthyma and infection
11) Confidence 0.24 Published 2005 Journal Virol J Section Body Doc Link PMC1243244 Disease Relevance 1.04 Pain Relevance 0
Subgroup analysis of those patients enrolled in ACTG who had CD4+ T cell counts below 200/?
Regulation (had) of Gene_expression (counts) of CD4 in T cell
12) Confidence 0.19 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676642 Disease Relevance 0.80 Pain Relevance 0
These data suggest that CREB may have a dual role in cytokine expression in CD4 T cells by directly blocking the IFN-?
Spec (may) Regulation (role) of Gene_expression (expression) of CD4 in T cells associated with cytokine
13) Confidence 0.14 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.07 Pain Relevance 0.25
S100A7 is highly expressed in epidermal hyperproliferative disease and recruits CD4+ lymphocytes and neutrophils [102].
Regulation (recruits) of Gene_expression (lymphocytes) of CD4 in neutrophils associated with disease
14) Confidence 0.11 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.76 Pain Relevance 0
S100A7 is highly expressed in epidermal hyperproliferative disease and recruits CD4+ lymphocytes and neutrophils [102].
Regulation (recruits) of in lymphocytes Gene_expression (lymphocytes) of CD4 in neutrophils associated with disease
15) Confidence 0.04 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.76 Pain Relevance 0

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