INT174487

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Context Info
Confidence 0.71
First Reported 2003
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.64
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL4) extracellular region (IL4)
Anatomy Link Frequency
extracellular matrix 1
IL4 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 2 98.14 Very High Very High Very High
cytokine 42 94.32 High High
Arthritis 15 87.76 High High
chemokine 1 85.00 Quite High
psoriasis 4 77.08 Quite High
rheumatoid arthritis 107 67.60 Quite High
Inflammation 69 55.20 Quite High
Inflammatory stimuli 1 37.52 Quite Low
Inflammatory response 4 7.44 Low Low
tolerance 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Brain Tumor 7 99.56 Very High Very High Very High
Hypercalcemia 1 97.68 Very High Very High Very High
Immunization 10 96.48 Very High Very High Very High
Glioma 39 94.12 High High
Cancer 60 91.88 High High
Autoimmune Disease 19 91.12 High High
Communicable Diseases 1 90.20 High High
Arthritis 16 87.76 High High
Experimental Autoimmune Encephalomyelitis 2 85.44 High High
Psoriasis 4 77.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
, anti-IL-4 and isotype control antibodies (Caltag Laboratories) were added during the permeabilization step (1 ?
Protein_catabolism (added) of IL-4
1) Confidence 0.71 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193727 Disease Relevance 0 Pain Relevance 0.11
Although IL-4 is typically described as an inducer of a type-2 immune response [33], local delivery of IL-4 at an immunization site induced IL-12 production by antigen-presenting cells, and Th1-type responses in our pre-clinical tumor vaccine model [34] as well as in an infectious disease (Leishmania major) model [35].
Protein_catabolism (typically) of IL-4 associated with cancer, communicable diseases and immunization
2) Confidence 0.25 Published 2007 Journal J Transl Med Section Body Doc Link PMC2254376 Disease Relevance 0.81 Pain Relevance 0.04
In vitro, IL-4 suppresses metalloproteinase production and stimulates production of tissue inhibitor of metalloproteinases-1 in human mononuclear phagocytes and cartilage explants, indicating a protective effect of IL-4 toward extracellular matrix degradation.
Protein_catabolism (degradation) of IL-4 in extracellular matrix associated with metalloproteinase
3) Confidence 0.17 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 0.82 Pain Relevance 0.40

General Comments

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