INT174492

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Context Info
Confidence 0.39
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 5.08
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cd3e) signal transducer activity (Cd3e)
Anatomy Link Frequency
lymphocytes 4
T cells 4
Cd3e (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 38 98.96 Very High Very High Very High
tolerance 13 97.32 Very High Very High Very High
spinal inflammation 50 84.36 Quite High
Potency 2 78.84 Quite High
cytokine 70 74.96 Quite High
Spinal cord 12 68.80 Quite High
rheumatoid arthritis 27 63.92 Quite High
Arthritis 34 42.88 Quite Low
Multiple sclerosis 13 5.00 Very Low Very Low Very Low
isoflurane 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 111 99.56 Very High Very High Very High
Disease 71 99.28 Very High Very High Very High
INFLAMMATION 35 98.96 Very High Very High Very High
Sprains And Strains 115 98.68 Very High Very High Very High
Diabetes Mellitus 48 98.48 Very High Very High Very High
Cancer 76 98.36 Very High Very High Very High
Apoptosis 10 97.36 Very High Very High Very High
Targeted Disruption 17 96.04 Very High Very High Very High
Hypersensitivity 7 96.04 Very High Very High Very High
Hematological Disease 18 95.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As the result, a proportion of CD3int CD4high CD8- lymphocytes markedly increased in lethal-infection with the WR strain (23.5%) compared to uninfected controls (4.4%) at 5 days post-infection (Fig. 5D).
Positive_regulation (increased) of Gene_expression (proportion) of CD3int in lymphocytes associated with sprains and strains and infection
1) Confidence 0.39 Published 2007 Journal Virol J Section Body Doc Link PMC1810241 Disease Relevance 1.14 Pain Relevance 0
Consistent with these cytometry data, immunohistochemical analysis of tissue sections indicated that the tumor cells present in both hematopoietic and non–hematopoietic tissues displayed high levels of CD3 expression (Figure 2B).
Positive_regulation (levels) of Gene_expression (expression) of CD3 associated with cancer
2) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 1.15 Pain Relevance 0
After allogeneic bone marrow transplantation, flow cytometric analysis showed very few non-CD3+ lymphocytes and a high proportion of CD3+ lymphocytes in surviving mice.
Positive_regulation (proportion) of Gene_expression (lymphocytes) of CD3 in lymphocytes
3) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2701999 Disease Relevance 0.62 Pain Relevance 0
Interestingly, as shown in Fig. 6a, upon in vitro re-stimulation with plate-bound anti-CD3 and soluble anti-CD28, CD4+CD25+ and CD4+CD25?
Positive_regulation (upon) of Gene_expression (shown) of CD3
4) Confidence 0.21 Published 2010 Journal Diabetologia Section Body Doc Link PMC2910887 Disease Relevance 0.37 Pain Relevance 0.09
The proportion of CD3+, CD4+, and CD8+ T cells tended to increase slightly over the assay period, but the differences were not significant.
Positive_regulation (increase) of Gene_expression (proportion) of CD3 in T cells
5) Confidence 0.12 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2596084 Disease Relevance 0 Pain Relevance 0.07
Also, the relative proportion of CD3-expression was increased, suggesting decrease of the other populations.
Positive_regulation (increased) of Gene_expression (expression) of CD3
6) Confidence 0.06 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875643 Disease Relevance 0.24 Pain Relevance 0
We suspect that increased levels of CD3+CD4+CD28- T cells in the elderly may be a consequence of reduced apoptosis and persistence of these cells after an inflammatory disease over the years.
Positive_regulation (increased) of Gene_expression (levels) of CD3 in T cells associated with inflammation, disease and apoptosis
7) Confidence 0.05 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193730 Disease Relevance 1.44 Pain Relevance 0.47
These cells were stimulated with anti-CD3 and anti-CD28 antibodies (both at 1 ?
Positive_regulation (stimulated) of Gene_expression (antibodies) of CD3
8) Confidence 0.04 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2525626 Disease Relevance 0.12 Pain Relevance 0.13

General Comments

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