INT174503

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Context Info
Confidence 0.37
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.48
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HLA-B, KIR3DL1)
HLA-B (Homo sapiens)
KIR3DL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 245 99.28 Very High Very High Very High
Inflammation 12 91.84 High High
rheumatoid arthritis 17 73.28 Quite High
tolerance 7 64.24 Quite High
endometriosis 12 39.12 Quite Low
psoriasis 2 21.56 Low Low
Arthritis 6 5.00 Very Low Very Low Very Low
spondylitis 4 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Multiple sclerosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Low Back Pain 249 99.28 Very High Very High Very High
Spondylarthropathies 1 98.68 Very High Very High Very High
Disease 55 92.16 High High
INFLAMMATION 12 91.84 High High
Infection 8 89.72 High High
Epstein-barr Virus 16 89.52 High High
Rheumatoid Arthritis 18 73.28 Quite High
Graft Vs Host Disease 6 67.36 Quite High
Cytomegalovirus Infection 13 65.12 Quite High
Targeted Disruption 6 62.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This could be the case of the KIR3DL1 inhibitory receptor, the only KIR known to recognise HLA-B alleles.
HLA-B Binding (recognise) of KIR
1) Confidence 0.37 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779409 Disease Relevance 0.37 Pain Relevance 0.24
However, it has been described that HLA-B*2705, which carries a Bw4 epitope containing threonine at residue 80, is also recognised by KIR3DL1, this interaction being peptide-specific [23].
HLA-B Binding (recognised) of KIR3DL1
2) Confidence 0.33 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779409 Disease Relevance 0.48 Pain Relevance 0.18
It is therefore plausible that the presence of another HLA-B allele carrying the Bw4-I80 epitope may antagonise the unfavourable interaction of KIR3DL1 with an HLA-B27-peptide.
HLA-B27-peptide Binding (interaction) of KIR3DL1
3) Confidence 0.32 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779409 Disease Relevance 0.43 Pain Relevance 0.18
In fact, it has been shown that KIR3DL1 recognises HLA-B27 molecules when loaded with a self-peptide and with a number of viral non-self-peptides.
HLA-B27 Binding (recognises) of KIR3DL1
4) Confidence 0.32 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779409 Disease Relevance 0.37 Pain Relevance 0.09
In our study, we have not seen any association of KIR3DL1, putative receptor of HLA-B27 [17], [18], and only weak association of KIR3DS1, with ankylosing spondylitis (data not shown).
HLA-B27 Binding (association) of KIR3DL1 associated with spinal inflammation
5) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928722 Disease Relevance 0.71 Pain Relevance 0.51
These aberrant forms of HLA-B27 can be recognized by immunomodulatory killer cell immunoglobulin receptors, such as KIR3DL1 and KIR3DL2, and the immunoglobulin-like transcript ILT-4.
HLA-B27 Binding (recognized) of KIR3DL1
6) Confidence 0.08 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193730 Disease Relevance 1.12 Pain Relevance 0.41

General Comments

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