INT174508

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Context Info
Confidence 0.14
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 4.68
Pain Relevance 1.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CD4, HLA-B) signal transduction (CD4) cell adhesion (CD4)
enzyme binding (CD4)
Anatomy Link Frequency
T cells 2
CD4 (Homo sapiens)
HLA-B (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 200 99.78 Very High Very High Very High
Arthritis 8 85.68 High High
Inflammation 16 72.80 Quite High
rheumatoid arthritis 24 40.72 Quite Low
Multiple sclerosis 8 14.56 Low Low
spondylitis 16 5.00 Very Low Very Low Very Low
cytokine 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Low Back Pain 216 99.78 Very High Very High Very High
Rheumatoid Arthritis 28 99.12 Very High Very High Very High
Targeted Disruption 8 97.76 Very High Very High Very High
Cytomegalovirus Infection 52 95.08 Very High Very High Very High
Disease 112 93.44 High High
Epstein-barr Virus 48 93.28 High High
Arthritis 4 85.68 High High
Spondylarthropathies 4 79.60 Quite High
INFLAMMATION 16 72.80 Quite High
Apoptosis 28 70.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Most of the HLA-B27 mediated proliferative effect could be inhibited by CD4 specific monoclonal antibodies, suggesting a CD4 mediated recognition of the HLA-B27 molecule.
CD4 Binding (recognition) of HLA-B27
1) Confidence 0.14 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193730 Disease Relevance 1.10 Pain Relevance 0.30
Most of the HLA-B27 mediated proliferative effect could be inhibited by CD4 specific monoclonal antibodies, suggesting a CD4 mediated recognition of the HLA-B27 molecule.
CD4 Binding (recognition) of HLA-B27
2) Confidence 0.11 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193730 Disease Relevance 1.23 Pain Relevance 0.33
Several more recent studies have raised the possibility that HLA-B27 may be more than a restriction element of CD8+ T cells in AS, and that HLA-B27 may be recognized even by CD4+ T cells [6,7].
CD4 Binding (recognized) of HLA-B27 in T cells associated with spinal inflammation
3) Confidence 0.11 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193730 Disease Relevance 0.98 Pain Relevance 0.53
Interestingly, HLA-B27 interacts with CD4+ T cells via several different modes of action.
CD4 Binding (interacts) of HLA-B27 in T cells
4) Confidence 0.11 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193730 Disease Relevance 1.37 Pain Relevance 0.38

General Comments

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