INT17451

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 1987
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 23
Total Number 24
Disease Relevance 8.85
Pain Relevance 9.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Tst) RNA binding (Tst) plasma membrane (Tst)
Anatomy Link Frequency
skin 2
CBT 2
Upper body 1
brain 1
Tst (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 24 100.00 Very High Very High Very High
narcan 50 99.82 Very High Very High Very High
tolerance 22 99.32 Very High Very High Very High
Morphine 51 99.26 Very High Very High Very High
Clonidine 9 98.96 Very High Very High Very High
withdrawal 44 98.92 Very High Very High Very High
agonist 21 98.20 Very High Very High Very High
electroacupuncture 5 97.22 Very High Very High Very High
Pain 5 95.44 Very High Very High Very High
antagonist 79 95.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 24 100.00 Very High Very High Very High
Stroke 5 99.72 Very High Very High Very High
Mycobacterial Infection 55 99.62 Very High Very High Very High
Latent Tuberculosis 95 99.04 Very High Very High Very High
Anaerobic Bacterial Infections 1 98.44 Very High Very High Very High
Increased Venous Pressure Under Development 28 98.36 Very High Very High Very High
Metabolic Syndrome 6 98.26 Very High Very High Very High
Complex Regional Pain Syndromes 9 98.24 Very High Very High Very High
Hirsutism 31 97.28 Very High Very High Very High
Diarrhoea 1 97.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Electroacupuncture (2/100 Hz alternately) administered once daily for 7 days during morphine withdrawal facilitated the recovery of male sexual behavior and increased TST concentrations to above normal.
Positive_regulation (increased) of TST associated with withdrawal, electroacupuncture and morphine
1) Confidence 0.67 Published 2004 Journal Neurochem. Res. Section Abstract Doc Link 15002736 Disease Relevance 0 Pain Relevance 0.83
Increased TST positivity was associated with being Black (AOR = 3.53, CI = 1.28-9.77), Hispanic (AOR = 3.11, CI = 1.12-8.60), and having higher education (AOR = 3.01, CI = 1.20-7.53).
Positive_regulation (Increased) of TST
2) Confidence 0.62 Published 2009 Journal Am J Drug Alcohol Abuse Section Body Doc Link 20014914 Disease Relevance 0 Pain Relevance 0
In a subsequent study central administration of the LH-RH agonist (5 micrograms/10 microliters) resulted in a similar rise in serum LH in both control and morphine-dependent rats, suggesting that the elevation in TST is not closely associated with LH secretion.
Positive_regulation (elevation) of TST associated with agonist and morphine
3) Confidence 0.61 Published 1989 Journal Brain Res. Section Abstract Doc Link 2670064 Disease Relevance 0 Pain Relevance 0.92
Clonidine caused decreases in TST and CBT, MDL-100907 caused increases in TST while decreasing CBT, and EE caused decreases in TST with minor CBT decreases only at the higher dose.
Positive_regulation (increases) of TST in CBT associated with clonidine
4) Confidence 0.60 Published 2009 Journal J. Neurosci. Methods Section Abstract Doc Link 19135085 Disease Relevance 0.05 Pain Relevance 0.29
Collectively, these data suggest that a TST increase is a component of the response of rats to local brain glucoprivation induced by 2DG.
Positive_regulation (increase) of TST in brain
5) Confidence 0.47 Published 1990 Journal Life Sci. Section Abstract Doc Link 2388522 Disease Relevance 0 Pain Relevance 0.63
A major advantage of measuring TST and CBT in the same animal is the ability to relate temporal changes on these two temperature parameters.
Positive_regulation (measuring) of TST in TST
6) Confidence 0.43 Published 2009 Journal J. Neurosci. Methods Section Abstract Doc Link 19135085 Disease Relevance 0.19 Pain Relevance 0.24
Treatment with a 5-HT(2A/2C) receptor agonist, (-)-2,5-dimethoxy-4-iodoamphetamine hydrochloride (DOI), prevented the naloxone-induced TST increase in the MD model and restored normal active-phase TST in the telemetry model.
Positive_regulation (increase) of TST associated with narcan and agonist
7) Confidence 0.41 Published 2004 Journal Brain Res. Section Abstract Doc Link 15527744 Disease Relevance 0.36 Pain Relevance 0.50
Interestingly, MDL-100907 increased TST in both models when given alone, with the TST increase occurring prior to the naloxone-induced flush in the MD model.
Positive_regulation (increase) of TST associated with narcan and increased venous pressure under development
8) Confidence 0.41 Published 2004 Journal Brain Res. Section Abstract Doc Link 15527744 Disease Relevance 0.35 Pain Relevance 0.54
Regardless of the central site of naloxone injection, TST was significantly increased 4-5 degrees C.
Positive_regulation (increased) of TST associated with narcan
9) Confidence 0.41 Published 1987 Journal Brain Res. Bull. Section Abstract Doc Link 3651842 Disease Relevance 0.09 Pain Relevance 0.74
In the telemetry model, mirtazapine (0.3-3 mg/kg, i.p.) caused an increase in TST.
Positive_regulation (increase) of TST
10) Confidence 0.41 Published 2006 Journal Brain Res. Section Abstract Doc Link 17067560 Disease Relevance 0.13 Pain Relevance 0.21
However, at the highest dose tested (10 mg/kg, i.p.), mirtazapine induced a small but significant decrease in TST followed by an increase in TST.
Positive_regulation (increase) of TST
11) Confidence 0.41 Published 2006 Journal Brain Res. Section Abstract Doc Link 17067560 Disease Relevance 0.12 Pain Relevance 0.20
Patients without a history of TB or a positive TST had a TST with Tubersol, as well as candida and tetanus controls, placed by the Mantoux method.
Positive_regulation (had) of TST associated with mycobacterial infection and anaerobic bacterial infections
12) Confidence 0.40 Published 1998 Journal Am. J. Kidney Dis. Section Abstract Doc Link 9590196 Disease Relevance 0.87 Pain Relevance 0
Young rats showed the expected TST increase and Tr decline in response to withdrawal.
Positive_regulation (increase) of TST associated with withdrawal
13) Confidence 0.40 Published 1994 Journal Exp. Gerontol. Section Abstract Doc Link 8187842 Disease Relevance 0.49 Pain Relevance 0.92
CONCLUSIONS: These results confirm a similar high prevalence of TST positivity in opioid-dependent patients enrolling in MMT and BMT programs.
Positive_regulation (prevalence) of TST
14) Confidence 0.39 Published 2009 Journal Am J Drug Alcohol Abuse Section Body Doc Link 20014914 Disease Relevance 0 Pain Relevance 0
A 5 degrees C increase in TST and a 1-2 degrees C decrease in rectal temperature (Tr) was observed following administration of a dose of naloxone HCl (NAL, 1 mg/kg, s.c.) which precipitated withdrawal in morphine-dependent rats.
Positive_regulation (increase) of TST associated with narcan, withdrawal and morphine
15) Confidence 0.39 Published 1987 Journal Brain Res. Section Abstract Doc Link 2825916 Disease Relevance 0 Pain Relevance 1.01
Administration of 5 or 10 micrograms of the LH-RH agonist (Des-Gly10, [im-Bzl-D-His6]LH-RH ethylamide) into the LV produced a significantly greater elevation in TST (4 degrees C) in the morphine-dependent rats compared to a negligible rise in TST in the control rats; however, administration of a larger dose of 20 micrograms of the LH-RH agonist produced similar TST responses of about 4 degrees C in both groups.
Positive_regulation (elevation) of TST associated with agonist and morphine
16) Confidence 0.35 Published 1989 Journal Brain Res. Section Abstract Doc Link 2670064 Disease Relevance 0.17 Pain Relevance 0.88
The mean maximal elevation in TST of the control animals was 6.4 +/- 0.2 degrees C.
Positive_regulation (elevation) of TST
17) Confidence 0.29 Published 1991 Journal Maturitas Section Abstract Doc Link 1907349 Disease Relevance 0.65 Pain Relevance 0.22
A major advantage of measuring TST and CBT in the same animal is the ability to relate temporal changes on these two temperature parameters.
Positive_regulation (measuring) of TST in CBT
18) Confidence 0.15 Published 2009 Journal J. Neurosci. Methods Section Abstract Doc Link 19135085 Disease Relevance 0.19 Pain Relevance 0.24
Furthermore, stroke patients had increased TST but not QSART responses on the contralesional limb (P < 0.05) and skin temperature was decreased (P < 0.001).
Neg (not) Positive_regulation (increased) of TST in skin associated with stroke
19) Confidence 0.14 Published 2001 Journal Acta Neurol. Scand. Section Abstract Doc Link 11153885 Disease Relevance 1.25 Pain Relevance 0.24
Therefore, a positive result to either an IGRA or TST, in addition to currently recommended clinical screening for risk factors for LTBI, should prompt consideration of preventive treatment of LTBI in this population.



Positive_regulation (result) of TST associated with latent tuberculosis
20) Confidence 0.11 Published 2008 Journal Autoimmun Rev Section Abstract Doc Link PMC2593775 Disease Relevance 0.95 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox