INT174511

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Context Info
Confidence 0.41
First Reported 2003
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.31
Pain Relevance 1.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CD28) plasma membrane (CD28)
Anatomy Link Frequency
T cells 10
CD28 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 100 99.20 Very High Very High Very High
Inflammation 42 98.96 Very High Very High Very High
spinal inflammation 193 96.84 Very High Very High Very High
Arthritis 56 93.32 High High
abatacept 69 78.16 Quite High
tolerance 6 72.60 Quite High
cytokine 51 63.76 Quite High
psoriasis 1 45.36 Quite Low
methotrexate 25 5.00 Very Low Very Low Very Low
spondylitis 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 136 99.28 Very High Very High Very High
Rheumatoid Arthritis 103 99.20 Very High Very High Very High
INFLAMMATION 49 98.96 Very High Very High Very High
Apoptosis 46 97.72 Very High Very High Very High
Low Back Pain 201 96.84 Very High Very High Very High
Seronegative Spondarthritis 50 93.32 High High
Cytomegalovirus Infection 34 93.04 High High
Aging 103 83.68 Quite High
Autoimmune Disease 19 77.12 Quite High
Epstein-barr Virus 26 74.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This co-incubation with HLA-B27 transfected C1R cells resulted in an increased expression of CD25 on CD4+CD28- T cells in the presence of cross-linking of T cell receptors as compared with co-incubation with nontransfected C1R cells (P = 0.012) and cross-linking of T cell receptors alone (P = 0.012; Fig. 5a).
Positive_regulation (increased) of Gene_expression (expression) of CD28 in T cell
1) Confidence 0.41 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193730 Disease Relevance 0 Pain Relevance 0
We suspect that increased levels of CD3+CD4+CD28- T cells in the elderly may be a consequence of reduced apoptosis and persistence of these cells after an inflammatory disease over the years.
Positive_regulation (increased) of Gene_expression (levels) of CD28 in T cells associated with inflammation, disease and apoptosis
2) Confidence 0.41 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193730 Disease Relevance 1.44 Pain Relevance 0.47
As expected, LPS-induced perforin production of CD4+CD28null T cells was reversed by blocking sCD14 and mCD14 (24.0 ± 16.3% versus 3.1 ± 2.5% perforin+ cells, P = 0.006) but not by isotype control antibody (Figure 5b).
Positive_regulation (induced) of Gene_expression (production) of CD28null in T cells
3) Confidence 0.41 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297589 Disease Relevance 0.24 Pain Relevance 0.24
in vivo on PRR expression of CD4+CD28null T cells
Positive_regulation (on) of Gene_expression (expression) of CD28null in T cells
4) Confidence 0.41 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297589 Disease Relevance 0.11 Pain Relevance 0.11
In our experiments both the addition of recombinant sCD14 and autologous serum had a comparable additional effect on LPS-induced perforin production of CD4+CD28null T cells, which indicates serum LPS binding protein not to be indispensable in AS.
Positive_regulation (-) of Neg (not) Gene_expression (production) of CD28null in T cells associated with spinal inflammation
5) Confidence 0.38 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297589 Disease Relevance 0.59 Pain Relevance 0.39
CD28 expression is increased in CD4+ cells from RA patients compared with controls, and the mean expression of CD28 is greatest for patients with clinically active disease (Salazar-Fontana et al 2001).
Positive_regulation (increased) of Gene_expression (expression) of CD28 associated with rheumatoid arthritis and disease
6) Confidence 0.33 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936358 Disease Relevance 1.11 Pain Relevance 0.51
The IRP includes increased levels of CD8+ CD28?
Positive_regulation (increased) of Gene_expression (levels) of CD28
7) Confidence 0.25 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684090 Disease Relevance 0.82 Pain Relevance 0.10

General Comments

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