INT174516

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Context Info
Confidence 0.27
First Reported 2003
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.20
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (ISG20) nucleoplasm (ISG20) RNA binding (ISG20)
nucleus (ISG20) intracellular (ISG20)
Anatomy Link Frequency
T cells 4
immune cells 2
ISG20 (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 104 98.68 Very High Very High Very High
Inflammation 48 50.88 Quite High
cytokine 42 50.00 Quite Low
Antihistamine 2 33.12 Quite Low
pruritus 4 27.96 Quite Low
rheumatoid arthritis 8 18.72 Low Low
spinal inflammation 50 10.16 Low Low
Inflammatory response 4 6.96 Low Low
tolerance 9 5.00 Very Low Very Low Very Low
Dismenorea 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 46 99.30 Very High Very High Very High
Endometriosis 180 98.68 Very High Very High Very High
Cicatrix 94 97.76 Very High Very High Very High
Cancer 30 84.80 Quite High
Disease 54 81.12 Quite High
Mycosis Fungoides 12 76.32 Quite High
Syndrome 12 76.08 Quite High
Apoptosis 35 75.20 Quite High
Hypoalbuminemia 3 64.08 Quite High
Exanthema 1 63.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In an unpublished meta-analysis of three phase III clinical trials of denileukin diftitox for the treatment of CTCL, Negro-Vilar also reported there was no correlation between CD25 expression and response.33

Denileukin diftitox in combination treatments

Neg (no) Regulation (correlation) of Gene_expression (expression) of CD25 associated with lymphatic system cancer
1) Confidence 0.27 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004568 Disease Relevance 0.54 Pain Relevance 0
No differences in CD25 expression were identified between ovarian endometriosis and the control group.
Neg (No) Regulation (differences) of Gene_expression (expression) of CD25 associated with endometriosis
2) Confidence 0.18 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.85 Pain Relevance 0.52
The alterations in RCAS1 and Metallothionein expression are accompanied by changes in CD25, CD56 and CD69 antigens expression on immune cells.
Regulation (changes) of Gene_expression (expression) of CD25 in immune cells
3) Confidence 0.18 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.35 Pain Relevance 0.30
No changes in CD25 expression on T cells were observed when comparing untreated cells to those treated for 18 hours with either MTB or CW (data not shown).


Neg (No) Regulation (changes) of Gene_expression (expression) of CD25 in T cells
4) Confidence 0.17 Published 2010 Journal BMC Immunol Section Body Doc Link PMC2858026 Disease Relevance 0.28 Pain Relevance 0.03
No changes in CD25 expression were seen on the CD4+CD28+ T cells.
Neg (No) Regulation (changes) of Gene_expression (expression) of CD25 in T cells
5) Confidence 0.13 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193730 Disease Relevance 0 Pain Relevance 0
The presence of catalytically active Trx1 impeded CD30-dependent signaling in the YT lymphoma cell line, as demonstrated by its effect on CD25 and FasL expression, as well as its influence on cytotoxicity against Fas-expressing target cells.
Regulation (effect) of Gene_expression (expression) of CD25 associated with lymphatic system cancer
6) Confidence 0.11 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.17 Pain Relevance 0

General Comments

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