INT17452

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Context Info
Confidence 0.46
First Reported 1980
Last Reported 2011
Negated 3
Speculated 1
Reported most in Body
Documents 14
Total Number 16
Disease Relevance 1.50
Pain Relevance 1.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Dlst) plasma membrane (Dlst) nucleus (Dlst)
transferase activity, transferring acyl groups (Dlst) cytoplasm (Dlst)
Anatomy Link Frequency
peritoneum 2
lateral lobe 1
striatum 1
vertebrae 1
uterus 1
Dlst (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 35 99.98 Very High Very High Very High
opiate 3 97.88 Very High Very High Very High
narcan 5 96.32 Very High Very High Very High
Central nervous system 10 93.52 High High
Morphine 1 92.00 High High
vagus nerve 25 91.00 High High
withdrawal 1 87.04 High High
Inflammation 38 79.40 Quite High
Dynorphin 1 73.40 Quite High
medulla 5 67.76 Quite High
Disease Link Frequency Relevance Heat
Reprotox - General 3 3 96.84 Very High Very High Very High
Ganglion Cysts 15 95.48 Very High Very High Very High
Endometriosis (extended) 3 88.40 High High
Substance Withdrawal Syndrome 1 87.40 High High
Increased Venous Pressure Under Development 10 87.20 High High
Body Weight 35 80.32 Quite High
INFLAMMATION 37 79.40 Quite High
Acidosis 2 76.68 Quite High
Sprains And Strains 11 59.44 Quite High
Decapitation 12 54.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another possibility explaining the differences on E2 secretion regulation during the estrous cycle is that the effects of the cholinergic system take place through changes at the celiac ganglion level.
Regulation (regulation) of E2 in celiac ganglion associated with ganglion cysts
1) Confidence 0.46 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1564398 Disease Relevance 0.24 Pain Relevance 0.07
The aim of this paper was to study whether prostaglandins (PGs) E1, E2 and F2 alpha affect the binding of specific ligands for dopaminergic or opiate receptors 3H-spiroperidol or 3H-naloxone in the rat striatum.
Spec (whether) Regulation (affect) of E2 in striatum associated with narcan and opiate
2) Confidence 0.43 Published 1980 Journal Pol J Pharmacol Pharm Section Abstract Doc Link 6267565 Disease Relevance 0 Pain Relevance 0.33
Tamoxifen (250 micrograms/kg.day, sc) administered simultaneously antagonized the action of E2 on Prodyn gene expression.
Regulation (action) of E2
3) Confidence 0.39 Published 1995 Journal Endocrinology Section Abstract Doc Link 7895668 Disease Relevance 0 Pain Relevance 0.04
Since perforating the peritoneum unilaterally on each day of the estrous cycle changed E2 serum concentrations, we think that each side of the peritoneum sends different neural information through the superior ovarian nerve (SON) to the ovary and the central nervous system, perhaps reaching nuclei related to the vagus nerve.
Regulation (changed) of E2 in peritoneum associated with central nervous system and vagus nerve
4) Confidence 0.33 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1564398 Disease Relevance 0 Pain Relevance 0.09
Further decrement in depth of anesthesia changed the biphasic E2+E1 abdominal motor activity pattern to E-all activity pattern in the vagus-intact neonatal rat.
Regulation (changed) of E2 associated with anesthesia
5) Confidence 0.33 Published 2010 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 20217340 Disease Relevance 0.14 Pain Relevance 0.19
The results indicate that ULO effects on E2 concentrations are asymmetric, vary during the estrous cycle, and partially depend on the cholinergic innervation.
Regulation (effects) of E2
6) Confidence 0.29 Published 2006 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1564398 Disease Relevance 0 Pain Relevance 0
The effects on E2 serum concentrations of unilaterally or bilaterally perforating the peritoneum depended on the side of the peritoneum and the stage of the estrous cycle when perforation surgery was performed.
Regulation (effects) of E2 in peritoneum
7) Confidence 0.29 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1564398 Disease Relevance 0 Pain Relevance 0.27
The present study was designed to evaluate the effects of E2-CDS vs.
Regulation (effects) of E2
8) Confidence 0.27 Published 1991 Journal Maturitas Section Abstract Doc Link 1907349 Disease Relevance 0.67 Pain Relevance 0.21
1) increased the BMD values of the lumbar vertebrae proximal to the SMF-exposed area without any significant influence on the E2 levels.
Neg (without) Regulation (influence) of E2 in proximal
9) Confidence 0.21 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952315 Disease Relevance 0.12 Pain Relevance 0
Compared to the control group, ether anesthesia treatment did not modify E2 serum concentrations (D1: 62.9 ± 8.4; D2: 69.5 ± 12.0; P: 164.1 ± 17.6).
Neg (not) Regulation (modify) of E2 associated with anesthesia
10) Confidence 0.17 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1564398 Disease Relevance 0.05 Pain Relevance 0.28
1 significantly increased the BMD values of the osteoporotic lumbar vertebrae in ovariectomized rats without significantly influencing the E2 levels.
Neg (without) Regulation (influencing) of E2 in vertebrae
11) Confidence 0.15 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952315 Disease Relevance 0 Pain Relevance 0
E2 is a major factor controlling CaBP-9k gene expression in the rat uterus.
Regulation (controlling) of E2 in uterus
12) Confidence 0.11 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1594574 Disease Relevance 0 Pain Relevance 0.06
Taken together, we demonstrated that an alteration in various mRNAs of gene profiles is one of the most significant factors at the transcriptional level in the reproductive tissue following E2, DES or estrogenic compounds.
Regulation (one) of E2
13) Confidence 0.09 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1594574 Disease Relevance 0 Pain Relevance 0
To examine changes in responsiveness of estrogen-regulated genes to E2 in ventral prostate, offspring from different litters of untreated control groups A and B and 0.7, 7, and 24 mg/kg/day 4-MBC treatment groups were castrated at 70 days of age, and after 2 weeks recovery, injected with E2 (10 or 50 ?
Regulation (regulated) of E2 in ventral
14) Confidence 0.07 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2174398 Disease Relevance 0 Pain Relevance 0
In lateral lobe of prostate tissue, SOD activity was 37.82 ± 1.98, 31.59 ± 3.57, and 37.01 ± 3.95 (units/mL) for the normal control, E2 + DHT-treated, and oligonol-treated groups, respectively.
Regulation (control) of E2 in lateral lobe
15) Confidence 0.06 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2703763 Disease Relevance 0.28 Pain Relevance 0.14
Acute response to E2 in adult castrated rat offspring
Regulation (response) of E2
16) Confidence 0.05 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2174398 Disease Relevance 0 Pain Relevance 0

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