INT17453

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Context Info
Confidence 0.59
First Reported 1991
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 21
Disease Relevance 4.54
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Dlst) plasma membrane (Dlst) nucleus (Dlst)
transferase activity, transferring acyl groups (Dlst) cytoplasm (Dlst)
Anatomy Link Frequency
ovaries 6
peritoneum 4
left ovary 2
mammary gland 1
medial 1
Dlst (Rattus norvegicus)
Pain Link Frequency Relevance Heat
amygdala 16 94.88 High High
medulla 16 94.24 High High
withdrawal 3 94.20 High High
Hippocampus 16 94.00 High High
Inflammation 72 87.84 High High
vagus nerve 80 87.08 High High
narcan 3 79.52 Quite High
Morphine 1 78.56 Quite High
Central nervous system 32 75.88 Quite High
gABA 32 74.76 Quite High
Disease Link Frequency Relevance Heat
Reprotox - General 3 5 97.72 Very High Very High Very High
Ganglion Cysts 48 95.04 Very High Very High Very High
Substance Withdrawal Syndrome 1 94.56 High High
Hypertrophy 34 92.08 High High
INFLAMMATION 70 87.84 High High
Endometriosis (extended) 13 87.16 High High
Stress 10 82.24 Quite High
Aggression 4 80.60 Quite High
Body Weight 49 79.44 Quite High
Sprains And Strains 18 77.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results obtained in the present study suggest that each ovary's ability to compensate the secretion of E2 from the missing ovary is different and varies during the estrous cycle.
Localization (secretion) of E2 in ovary
1) Confidence 0.59 Published 2006 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1564398 Disease Relevance 0 Pain Relevance 0
Our results, and those of others, suggest that stimulating on D2 the sensory receptors located on the left side of the peritoneum triggers an E2 secretion inhibitory mechanism, that the sensory pathway arising from the right side has a stimulatory effect, and that both are mediated by the cholinergic muscarinic system.
Localization (secretion) of E2 in peritoneum
2) Confidence 0.59 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1564398 Disease Relevance 0 Pain Relevance 0.12
Ovarian denervation of rats in proestrus stage blocks E2 secretion induced by stimulating the medial basal pre-chiasmatic area.
Localization (secretion) of E2 in medial
3) Confidence 0.59 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1564398 Disease Relevance 0 Pain Relevance 0.12
Another possibility explaining the differences on E2 secretion regulation during the estrous cycle is that the effects of the cholinergic system take place through changes at the celiac ganglion level.
Localization (secretion) of E2 in celiac ganglion associated with ganglion cysts
4) Confidence 0.59 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1564398 Disease Relevance 0.24 Pain Relevance 0.07
The results also suggest that the cholinergic system participates in regulating ovarian E2 secretion.
Localization (secretion) of E2
5) Confidence 0.59 Published 2006 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1564398 Disease Relevance 0 Pain Relevance 0
Based on available information, the present study aims to analyze if changes in E2 secretion by the left and right ovaries vary during the estrous cycle, using the unilateral ovariectomized animal as a model of study.
Localization (secretion) of E2 in ovaries
6) Confidence 0.59 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1564398 Disease Relevance 0.29 Pain Relevance 0.16
The results agree with previously stated hypothesis of a neural pathway arising from the peritoneum that participates in regulating E2 secretion, and also supports the idea of cross-talk between the ovaries, via a neural communication, that modulates E2 secretion.



Localization (secretion) of E2 in peritoneum
7) Confidence 0.52 Published 2006 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1564398 Disease Relevance 0 Pain Relevance 0
The results agree with previously stated hypothesis of a neural pathway arising from the peritoneum that participates in regulating E2 secretion, and also supports the idea of cross-talk between the ovaries, via a neural communication, that modulates E2 secretion.



Localization (secretion) of E2 in peritoneum
8) Confidence 0.52 Published 2006 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1564398 Disease Relevance 0 Pain Relevance 0
Similarly, our results suggest that the cholinergic system participates in regulating E2 secretion by the ovary, and that such participation varies depending on the ovary remaining in situ and the stage of the estrous cycle when the surgical procedure was performed.
Localization (secretion) of E2 in ovary
9) Confidence 0.52 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1564398 Disease Relevance 0 Pain Relevance 0
The results obtained in the present study suggest that the ability to compensate the secretion of E2 by the missing ovary is different between the right and left ovaries and varies during the estrous cycle.
Localization (secretion) of E2 in ovaries
10) Confidence 0.52 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1564398 Disease Relevance 0 Pain Relevance 0
As previously proposed, another possibility is that neural communication between the ovaries modulates E2 secretion.



Localization (secretion) of E2 in ovaries
11) Confidence 0.52 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1564398 Disease Relevance 0.21 Pain Relevance 0.04
ULO rats treated with ATR on D2 or P, resulted in an asymmetrical E2 secretion response; when the right ovary remained in situ an increase in E2 was observed, and a decrease when the left ovary remained in situ.
Localization (secretion) of E2 in left ovary
12) Confidence 0.52 Published 2006 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1564398 Disease Relevance 0 Pain Relevance 0
We also investigated if, throughout estrous cycle diestrus 1 (D1), diestrus 2 (D2) and proestrus (P), the cholinergic system modulates E2 secretion in an asymmetric way.
Localization (secretion) of E2
13) Confidence 0.52 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1564398 Disease Relevance 0.31 Pain Relevance 0.14
We presume that the left ovary releases more E2 than the right one.
Localization (releases) of E2 in left ovary
14) Confidence 0.45 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1564398 Disease Relevance 0.23 Pain Relevance 0.04
Previously, we suggested the existence of a neural pathway arising from the peritoneum that participates in regulating E2 [9], P4 [10] and testosterone secretion [11].
Localization (secretion) of E2 in peritoneum
15) Confidence 0.45 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1564398 Disease Relevance 0 Pain Relevance 0.06
Based on the differences in E2 serum concentrations in rats with ULO, present results suggest that the capacity to release E2 by the left and right ovaries varies during the estrous cycle.
Localization (release) of E2 in ovaries
16) Confidence 0.45 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1564398 Disease Relevance 0.24 Pain Relevance 0.04
Thus, replacement therapy with a brain-enhanced estrogen delivery system (E2-CDS) with sustained release of estradiol (E2) in the brain may be more effective in the treatment of menopausal symptoms than currently used estrogens.
Localization (release) of E2 in brain associated with reprotox - general 3
17) Confidence 0.43 Published 1991 Journal Maturitas Section Abstract Doc Link 1907349 Disease Relevance 0.65 Pain Relevance 0.17
Serum LH concentrations were suppressed under both doses, which is typical for E2, whereas neither GEN dose affected LH serum values.
Localization (typical) of E2
18) Confidence 0.41 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2174401 Disease Relevance 0.15 Pain Relevance 0
E2 low induced luminar formation but no secretion, whereas in the mammary gland of E2 high animals, ample tissue and signs of secretion were observed.
Localization (secretion) of E2 in mammary gland
19) Confidence 0.39 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2174401 Disease Relevance 0.07 Pain Relevance 0
E2 given with DHT could restore wet prostate weight which does not include the secretion weight and could decrease secretion production as well.
Localization (secretion) of E2
20) Confidence 0.09 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2703763 Disease Relevance 1.07 Pain Relevance 0.25

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