INT174537

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Context Info
Confidence 0.39
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.07
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (HEYL) protein binding transcription factor activity (HEYL) DNA binding (HEYL)
transcription factor binding (HEYL) cytoplasm (HEYL)
Anatomy Link Frequency
spine 2
osteoblasts 1
HEYL (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 10 94.40 High High
aspirin 8 93.52 High High
rheumatoid arthritis 70 66.92 Quite High
Pain 3 62.92 Quite High
corticosteroid 8 53.48 Quite High
beta blocker 1 40.60 Quite Low
Analgesic 1 38.24 Quite Low
Opioid 1 34.96 Quite Low
methotrexate 4 32.20 Quite Low
Angina 1 25.72 Quite Low
Disease Link Frequency Relevance Heat
Premature Beats 12 98.68 Very High Very High Very High
Osteoporosis 168 93.72 High High
INFLAMMATION 12 86.92 High High
Diabetes Mellitus 7 86.28 High High
Gastrointestinal Disease 1 84.60 Quite High
Breast Cancer 50 84.32 Quite High
Obesity 67 82.36 Quite High
Colon Cancer 2 81.84 Quite High
Metabolic Syndrome 3 73.40 Quite High
Recurrence 2 72.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Measurements of HRT were done by the original method (10).
Positive_regulation (Measurements) of HRT
1) Confidence 0.39 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693810 Disease Relevance 0.84 Pain Relevance 0
Exposure to any of these drugs before the index date was classified as 'ever exposed to HRT' while exposure to none of them was classified as 'never exposed to HRT'.
Positive_regulation (exposed) of HRT
2) Confidence 0.03 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2656898 Disease Relevance 0.79 Pain Relevance 0.42
The reduction was followed by a significant increase within the HRT group during the second year (data not shown), which might indicate an anabolic effect on the osteoblasts by HRT, in line with our previous findings of an increase in insulin-like growth factor 1 in the HRT group [41].
Positive_regulation (increase) of HRT in osteoblasts
3) Confidence 0.03 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC546286 Disease Relevance 0.07 Pain Relevance 0.03
HRT resulted also in a significant (P = 0.035) but less pronounced reduction in the other collagen type I degradation product, ICTP.
Positive_regulation (resulted) of HRT
4) Confidence 0.03 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC546286 Disease Relevance 0 Pain Relevance 0
For patients who are unable or choose not to undergo HRT or take a bisphosphonate, a calcitonin is a viable alternative.
Positive_regulation (undergo) of HRT
5) Confidence 0.02 Published 2004 Journal International Journal of Medical Sciences Section Body Doc Link PMC1074710 Disease Relevance 0.53 Pain Relevance 0.22
The use of subcutaneous recombinant human GH for 18 months in combination with HRT, followed by HRT alone for 30 additional months, resulted in a 14% increase in lumbar spine bone mineral content at the 4-year follow-up versus HRT and placebo.
Positive_regulation (increase) of HRT in spine
6) Confidence 0.01 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193734 Disease Relevance 0.42 Pain Relevance 0
Interestingly, not only did the group given HRT + GH experience an increase in the bone mineral content of the spine and hip within the group and relative to the HRT-only group, but also the lumbar spine and femoral neck bone area was increased from baseline to year 4 in the group given HRT + GH [41].
Positive_regulation (increase) of HRT in spine
7) Confidence 0.01 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193734 Disease Relevance 0.44 Pain Relevance 0

General Comments

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