INT174540

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Context Info
Confidence 0.04
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.44
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (COL5A2) molecular_function (COL5A2)
Anatomy Link Frequency
synovial cells 2
COL5A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 24 99.36 Very High Very High Very High
fibrosis 3 94.92 High High
cytokine 17 91.64 High High
rheumatoid arthritis 96 91.48 High High
Osteoarthritis 48 80.96 Quite High
metalloproteinase 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
backache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 24 99.36 Very High Very High Very High
Apoptosis 14 98.76 Very High Very High Very High
Hyperplasia 1 96.80 Very High Very High Very High
Fibrosis 3 94.92 High High
Osteoporosis 41 94.88 High High
Rheumatoid Arthritis 96 91.48 High High
Hypercalcemia 15 88.92 High High
Obesity 1 82.04 Quite High
Frailty 49 80.96 Quite High
Fracture Healing 5 73.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Depending on the individual gene expression level in each patient, gene expression variances in regulatory pathways may lead to enhanced inflammation [53,54], angiogenesis [71,72], enhanced collagen synthesis and secretion [9], and/or a reduced rate of apoptosis [73], thus potentially contributing to hyperplasia of the SM [74], collagen-dependent fibrosis of the joints [64], and a prolonged life span of activated synovial cells in RA [73,75].
Positive_regulation (enhanced) of Localization (secretion) of collagen in synovial cells associated with fibrosis, inflammation, rheumatoid arthritis, apoptosis and hyperplasia
1) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575612 Disease Relevance 1.82 Pain Relevance 0.52
Its administration in in vitro experiments resulted in increased cell growth and increased matrix proteoglycan secretion and collagen synthesis.
Positive_regulation (increased) of Localization (secretion) of collagen
2) Confidence 0.01 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193734 Disease Relevance 0.62 Pain Relevance 0.08

General Comments

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