INT174541

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Context Info
Confidence 0.36
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 14.17
Pain Relevance 2.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (COL5A2) molecular_function (COL5A2)
Anatomy Link Frequency
fibroblasts 4
synovial fluid 2
chondrocyte 2
cartilage 2
tendon 2
COL5A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 59 99.36 Very High Very High Very High
Cannabinoid 26 98.04 Very High Very High Very High
Arthritis 32 96.72 Very High Very High Very High
metalloproteinase 15 96.68 Very High Very High Very High
Osteoarthritis 227 96.14 Very High Very High Very High
fibrosis 24 94.96 High High
cytokine 54 92.32 High High
rheumatoid arthritis 101 90.92 High High
methotrexate 7 89.48 High High
Chronic pancreatitis 31 87.32 High High
Disease Link Frequency Relevance Heat
Intervertebral Disk Degeneration 39 99.96 Very High Very High Very High
Targeted Disruption 6 99.88 Very High Very High Very High
Uterine Fibroids 240 99.56 Very High Very High Very High
Stress 13 99.44 Very High Very High Very High
INFLAMMATION 58 99.36 Very High Very High Very High
Cancer 144 99.04 Very High Very High Very High
Disease 142 98.76 Very High Very High Very High
Obesity 20 98.74 Very High Very High Very High
Apoptosis 48 98.20 Very High Very High Very High
Retina Disease 5 97.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Predisposing mechanical or ischemic factors could modify tendon collagen composition, characterized by both increased amounts of types III and V fibrils and diminished synthesis of type I collagen, which leads to abnormal fibrillogenesis and production of less resistant fibers that are more susceptible to rupture.
Positive_regulation (increased) of Gene_expression (synthesis) of collagen in tendon associated with rupture
1) Confidence 0.36 Published 2008 Journal Clinics Section Body Doc Link PMC2664193 Disease Relevance 0.41 Pain Relevance 0
Using a sandwich ELISA format based on polyclonal antibodies, this epitope has been demonstrated to be elevated in the synovial fluid in patients with OA, RA, and traumatic arthritis (Shinmei et al. 1993), and in the synovial fluid of individuals with varus knee alignment or obesity, suggesting that mechanical stress stimulates chondrocytes to increase collagen synthesis (Kobayashi et al. 2000).
Positive_regulation (increase) of Gene_expression (synthesis) of collagen in synovial fluid associated with stress, obesity, rheumatoid arthritis, osteoarthritis and arthritis
2) Confidence 0.22 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716783 Disease Relevance 1.42 Pain Relevance 0.29
Damage to cartilage also causes the chondrocyte to produce new type II collagen.
Positive_regulation (causes) of Gene_expression (produce) of collagen in chondrocyte
3) Confidence 0.13 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716783 Disease Relevance 0.36 Pain Relevance 0.14
1-induced upregulation of type I and III collagen expression in mouse fibroblasts [33].
Positive_regulation (upregulation) of Gene_expression (expression) of collagen in fibroblasts
4) Confidence 0.10 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875629 Disease Relevance 0.14 Pain Relevance 0.25
An increase in collagen synthesis due to vitamin C would however increase membrane mechanical integrity and cohesion and eventually prevent the growth of cancer cells.
Positive_regulation (increase) of Gene_expression (synthesis) of collagen associated with cancer
5) Confidence 0.09 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693571 Disease Relevance 1.56 Pain Relevance 0.03
Secondly, an increase in the synthesis of collagen inhibits the growth of cancer cells, leading to apoptosis and necrosis in cancer cells (18).
Positive_regulation (increase) of Gene_expression (synthesis) of collagen associated with necrosis, cancer and apoptosis
6) Confidence 0.09 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693571 Disease Relevance 1.63 Pain Relevance 0.08
Injection into the deep dermis has been shown to increase de novo collagen synthesis, hypothesized to be the result of fibroblast stretching.
Positive_regulation (increase) of Gene_expression (synthesis) of collagen in fibroblast
7) Confidence 0.07 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2946856 Disease Relevance 0.36 Pain Relevance 0.08
Transgenic mice expressing mutant alpha 1(IX) collagen were reported to have accelerated disc degeneration 12.
Positive_regulation (accelerated) of Gene_expression (expressing) of collagen associated with intervertebral disk degeneration and targeted disruption
8) Confidence 0.06 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.49 Pain Relevance 0
pathway can take place through different mechanisms, including stimulation of collagen synthesis and regulation of MMPs.31,32 Altered expression of TGF-?
Positive_regulation (stimulation) of Gene_expression (synthesis) of collagen
9) Confidence 0.05 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 0.60 Pain Relevance 0.14
Results showed that while static uniaxial tensile loads upregulated scleraxis expression, cyclic loading significantly enhanced collagen matrix production (Fig. 4).
Positive_regulation (enhanced) of Gene_expression (production) of collagen
10) Confidence 0.04 Published 2010 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2939640 Disease Relevance 0.18 Pain Relevance 0
Depending on the individual gene expression level in each patient, gene expression variances in regulatory pathways may lead to enhanced inflammation [53,54], angiogenesis [71,72], enhanced collagen synthesis and secretion [9], and/or a reduced rate of apoptosis [73], thus potentially contributing to hyperplasia of the SM [74], collagen-dependent fibrosis of the joints [64], and a prolonged life span of activated synovial cells in RA [73,75].
Positive_regulation (enhanced) of Gene_expression (synthesis) of collagen in synovial cells associated with fibrosis, inflammation, rheumatoid arthritis, apoptosis and hyperplasia
11) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575612 Disease Relevance 1.81 Pain Relevance 0.51
Leiomyomas are characterized by excessive collagen production in the ECM.7,16 We therefore evaluated the effect of ATRA treatment on collagen production in leiomyoma cell cultures by measuring salt soluble collagen secreted into the media after 24 h of ATRA treatment, prior to one cycle of cell division.
Positive_regulation (excessive) of Gene_expression (production) of collagen associated with uterine fibroids
12) Confidence 0.04 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 0.95 Pain Relevance 0
Thus, cannabinoid-induced suppression of MMP-2 could be a mediator of the induction of a more quiescent phenotype, leading to reduced collagen synthesis.
Positive_regulation (leading) of Gene_expression (synthesis) of collagen associated with cannabinoid
13) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2253501 Disease Relevance 1.06 Pain Relevance 0.40
The enhanced production of the cartilage-specific phenotypic markers, PGs and type II collagen, by MPCs in the presence of PPS was demonstrated in MMC using a quantitative radiochemical assay and semiquantitatively by immunostaining with a type II collagen antibody.
Positive_regulation (enhanced) of Gene_expression (production) of collagen in cartilage
14) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875662 Disease Relevance 0.11 Pain Relevance 0
Nevertheless, differences in collagen expression could contribute to similar end stage consequences of disease (e.g. retinal detachment) that occur rarely in toxoplasmosis (<10% of those with the most severe congenital toxoplasmosis) but commonly (>70%) in Sticklers disease, despite very different morphology of the vitreous and retinal findings, e.g. discrete chorioretinal lesions and optic neuritis and inflammatory cells in the vitreous for toxoplasmosis and lattice retinal degeneration with bands in vitreous for Stickler's disease.
Positive_regulation (contribute) of Gene_expression (expression) of collagen in bands associated with inflammation, optic neuritis, congenital toxoplasmosis, disease, neuritis, toxoplasmosis and retina disease
15) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2390765 Disease Relevance 1.53 Pain Relevance 0.13
FGF-2-supplemented expansion potentiated subsequent chondrogenic differentiation as the FGF-2-expanded cells showed a much greater increase in type II collagen expression than non-FGF-2-expanded cells.
Positive_regulation (increase) of Gene_expression (expression) of collagen
16) Confidence 0.01 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575620 Disease Relevance 0.51 Pain Relevance 0
Its administration in in vitro experiments resulted in increased cell growth and increased matrix proteoglycan secretion and collagen synthesis.
Positive_regulation (increased) of Gene_expression (synthesis) of collagen
17) Confidence 0.01 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193734 Disease Relevance 0.62 Pain Relevance 0.08
Strontium increases the synthesis of collagen and other proteins in osteoblasts and has been shown to increase replication of osteoblast progenitor cells [5,42].
Positive_regulation (increases) of Gene_expression (synthesis) of collagen in osteoblast associated with osteoporosis
18) Confidence 0.01 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193734 Disease Relevance 0.43 Pain Relevance 0

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