INT174551

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Context Info
Confidence 0.44
First Reported 2003
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.88
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

kinase activity (Tyrobp)
Anatomy Link Frequency
lymphocytes 2
T cell 2
Tyrobp (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 46 88.08 High High
tolerance 8 81.52 Quite High
Arthritis 3 50.00 Quite Low
Angina 1 43.44 Quite Low
Inflammation 12 36.12 Quite Low
Inflammatory response 2 27.84 Quite Low
cytokine 6 5.00 Very Low Very Low Very Low
withdrawal 5 5.00 Very Low Very Low Very Low
spinal inflammation 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acute Coronary Syndrome 10 97.96 Very High Very High Very High
Rheumatoid Arthritis 46 88.08 High High
Rupture 3 82.44 Quite High
Coronary Artery Disease 9 56.96 Quite High
Myocardial Infarction 2 54.40 Quite High
Aging 14 50.00 Quite Low
Autoimmune Disease 9 50.00 Quite Low
Arthritis 1 50.00 Quite Low
Cv General 3 Under Development 1 43.44 Quite Low
Thrombosis 1 38.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Absence of mature lymphocytes increases bone mass only in the absence of a functional DAP12 protein
Positive_regulation (increases) of Neg (absence) Gene_expression (absence) of DAP12 protein in lymphocytes
1) Confidence 0.44 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1899087 Disease Relevance 0 Pain Relevance 0
The coexpression of DAP12 and the stimulatory receptor encoded by the KIR2DS2 gene is sufficient to form an independent antigen recognition unit that confers the ability to fully activate a T cell, even in the absence of TCR triggering.
Positive_regulation (sufficient) of Gene_expression (coexpression) of DAP12 in T cell
2) Confidence 0.11 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193735 Disease Relevance 0.88 Pain Relevance 0.15

General Comments

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